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RUBICON SIGNED

Training network for Research on molecUlar and Biomechanical Interactions in CONnective tissue disorders

Total Cost €

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EC-Contrib. €

0

Partnership

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 Outcomes and results

 RUBICON project word cloud

Explore the words cloud of the RUBICON project. It provides you a very rough idea of what is the project "RUBICON" about.

respective    homeostasis    meetings    consolidate    reinforce    tissues    scientific    determinants    human    fertilise    equipped    additional    global    oxidative    arena    biochemists    commonalities    communication    innovation    cartilage    fundamental    excellent    secure    facilities    class    molecular    animal    cell    secondments    create    stress    basis    targetable    geneticists    soluble    laboratories    clock    data    components    laboratory    external    morphologists    connective    tendons    countries    exchange    disorders    focussed    tissue    interdisciplinary    pathophysiology    underlying    genetic    matrix    networking    biomechanical    signalling    network    extracellular    biologists    participating    biochemical    multidisciplinary    bone    training    clinicians    pathogenesis    attractive    groups    intracellular    mechanisms    er    webinars    instruments    diverse    scientists    technologies    recognised    circadian    rubicon    internationally    cross    courses    core    extensive    staff    young    skills    ethics    solid   

Project "RUBICON" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITA DEGLI STUDI DELL'AQUILA 

Organization address
address: PIAZZA SANTA MARGHERITA 2
city: L AQUILA
postcode: 67100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Project website http://rubicon-network.org/
 Total cost 877˙500 €
 EC max contribution 607˙500 € (69%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DELL'AQUILA IT (L AQUILA) coordinator 171˙000.00
2    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 144˙000.00
3    REGION HOVEDSTADEN DK (HILLEROD) participant 108˙000.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 94˙500.00
5    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 90˙000.00
6    ANNA UNIVERSITY CHENNAI IN (CHENNAI) partner 0.00
7    ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI US (NEW YORK) partner 0.00
8    MURDOCH CHILDRENS RESEARCH INSTITUTE AU (PARKVILLE) partner 0.00
9    THE UNIVERSITY OF HONG KONG HK (Pokfulam) partner 0.00
10    UNIVERSITY OF CAPE TOWN ZA (RONDEBOSCH) partner 0.00

Map

 Project objective

RUBICON will establish a global network for staff exchange of scientists and for research training focussed on connective tissue disorders. It will bring together leading scientific groups from 5 European and 5 non-European countries who will study the molecular and biomechanical factors involved in the pathophysiology of connective tissues, including tendons, cartilage and bone. The ambitious objectives of RUBICON are to increase our knowledge of the mechanisms underlying diverse connective tissue disorders, identify commonalities and targetable pathways, and reinforce multidisciplinary awareness in this fundamental research field. Researchers involved in secondments between RUBICON participants will investigate genetic determinants, circadian clock, extracellular matrix components, soluble biochemical factors and intracellular signalling pathways, ER stress and oxidative components involved in connective tissue homeostasis and pathogenesis. Extensive training during secondments will include new technologies and innovation, study design, interdisciplinary laboratory research, data analysis, research management, ethics in animal and human studies, and development of scientific and communication skills. All participating laboratories will ensure attractive working conditions in excellent and internationally recognised institutions, equipped with state-of-the-art instruments and excellent core facilities. Webinars, courses and meetings will provide additional opportunities for training and networking, also be open to external participants. RUBICON is a unique interdisciplinary network including cell biologists, molecular biologists, animal biologists, morphologists, geneticists, biochemists and clinicians who will cross-fertilise their respective research fields. The long-term goal of RUBICON is to consolidate a class of young scientists to secure future developments in the connective tissue arena and create a solid basis for further collaboration in this field.

 Deliverables

List of deliverables.
Press releases Websites, patent fillings, videos etc. 2020-02-20 16:54:37
Reports on RUBICON training events and webinars Documents, reports 2020-02-20 16:54:37
Info-packs describing arrangements for receiving staff exchanges Documents, reports 2020-02-20 16:54:37
Project website Websites, patent fillings, videos etc. 2020-02-20 16:54:37
Communication and media protocol Other 2020-02-20 16:54:37

Take a look to the deliverables list in detail:  detailed list of RUBICON deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Antonio Maurizi, Mattia Capulli, Annabel Curle, Rajvi Patel, Argia Ucci, Juliana Alves Côrtes, Harriet Oxford, Shireen R. Lamandé, John F. Bateman, Nadia Rucci, Anna Teti
Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications
published pages: , ISSN: 2095-6231, DOI: 10.1038/s41413-019-0055-x 		Bone Research 7/1 2020-03-11
2019 Peter Hung Thanh Tran
The mechanisms behind the development of tendinopathy: Early structural, inflammatory, nociceptive and clinical changes
published pages: , ISSN: , DOI: 		2020-02-20
2017 Maurizi A, Capulli M, Patel R, Rucci N, Teti.
CLCN7-dependent Autosomal Dominant Osteopetrosis type 2 (ADO2): more than a bone disease.
published pages: , ISSN: 0884-0431, DOI: 10.1002/jbmr.v32.S1 		Journal of Bone and Mineral Research 32/S1 2020-02-20
2017 Vimal Veeriah, University of L\'Aquila, Mattia Capulli, University of L\'Aquila, Angelo Zanniti
Interleukin 1β (IL1β), Nitric Oxide Synthase 2 (NOS2), Lipocalin 2 (LCN2) and Vascular Endothelial Growth Factor (VEGF) Orchestrate the Coupled Mechanoresponse of Skeletal Angiogenesis and Osteogenesis
published pages: , ISSN: 0884-0431, DOI: 10.1002/jbmr.v31.S1 		Journal of Bone and Mineral Research 31/S1 2020-02-20
2017 Antonio Maurizi, Nadia Rucci, Tina Schleicher, Yadhu Kumar, Anna Teti, Mattia Capulli,.
Transcriptomic Analysis of Osteoclasts from Autosomal Dominant Osteopetrosis type2 (ADO2) Mice harboring the G213R Mutation of the Chloride-Proton Antiporter type 7 (ClC7)
published pages: , ISSN: 1523-4681, DOI: 10.1002/jbmr.v32.S1/issuetoc 		Journal of Bone and Mineral Research 32/S1 2020-02-20
2017 Maurizi A, Capulli M, Patel R, Rucci N, Teti.
A deep phenotyping of autosomal dominant osteopetrosis type 2 (ADO2) mouse model revealed multiorgan dysfunctions.
published pages: , ISSN: , DOI: 		International Conference on Children Bone Health held in Würzburg, Germany, on June 10-13, 2017. 2020-02-20
2018 Vimal Veeriah, Riccardo Paone, Suvro Chatterjee, Anna Teti, Mattia Capulli
Osteoblasts Regulate Angiogenesis in Response to Mechanical Unloading
published pages: , ISSN: 0171-967X, DOI: 10.1007/s00223-018-0496-z 		Calcified Tissue International Nov 21 2020-02-20
2016 Vimal Veeriah, Angelo Zanniti, Riccardo Paone, Suvro Chatterjee, Nadia Rucci, Anna Teti, Mattia Capulli
Interleukin-1β, lipocalin 2 and nitric oxide synthase 2 are mechano-responsive mediators of mouse and human endothelial cell-osteoblast crosstalk
published pages: 6:29880, ISSN: 2045-2322, DOI: 10.1038/srep29880 		Scientific Reports 6/1 2020-02-20
2017 Anna Teti, Michael J. Econs
Osteopetroses, emphasizing potential approaches to treatment
published pages: pii: S8756-3282(, ISSN: 8756-3282, DOI: 10.1016/j.bone.2017.02.002 		Bone 102 2020-02-20
2018 John F. Bateman, Lisa Sampurno, Antonio Maurizi, Shireen R. Lamandé, Natalie A. Sims, Tegan L. Cheng, Aaron Schindeler, David G. Little
Effect of rapamycin on bone mass and strength in the α2(I)-G610C mouse model of osteogenesis imperfecta
published pages: , ISSN: 1582-1838, DOI: 10.1111/jcmm.14072 		Journal of Cellular and Molecular Medicine 2018;00:1‐11 2020-02-20

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