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MIRASYS

The diagnostic potential of miRNAs for early diagnosis of Systemic Sclerosis

Total Cost €

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EC-Contrib. €

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Partnership

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 MIRASYS project word cloud

Explore the words cloud of the MIRASYS project. It provides you a very rough idea of what is the project "MIRASYS" about.

diagnosis    assay    progression    designed    worldwide    approximately    tissue    symptoms    subjects    combination    feasibility    presented    prognostic    science    precede    monitoring    connective    grant    stage    profiles    diagnostics    onset    poc    impossible    models    patients    internal    life    commercialise    mirasys    strategic    thoroughly    analysed    commercial    setting    ip    autoimmune    complications    operate    disease    business    sclerosis    mirna    investors    actionable    unknown    breakthrough    erc    fibrosis    strategy    biomarkers    landscape    consists    boundaries    professionals    diagnostic    expression    positively    systemic    mirnas    demonstrated    correlates    incorporate    detection    organs    plan    panel    commercialisation    potent    prior    full    off    proprietary    position    microrna    skin    market    accelerate    formulate    consolidated    team    disorder    clinical    ssc    burden    found    company    threatening    160    elevated    manifestations    validate    characterised    spin    freedom   

Project "MIRASYS" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Netherlands [NL]
 Total cost 149˙190 €
 EC max contribution 149˙190 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 149˙190.00

Map

 Project objective

Systemic sclerosis (SSc) is a life-threatening autoimmune connective tissue disorder of unknown cause, characterised by fibrosis of the skin and internal organs. SSc affects approximately 160.000 patients worldwide and is associated with life-long burden of disease. Early detection of SSc is currently impossible as diagnosis is typically based on a combination of late-stage clinical symptoms. Current diagnostics, however, are based on late clinical manifestations. There is a need for actionable biomarkers for early-stage diagnosis and disease monitoring.

Based on proprietary ERC research specific microRNA (miRNA) profiles were found that positively correlates with clinical progression and complications of SSc. Its expression was elevated in subjects who demonstrated symptoms that can precede SSc onset by years. These findings provide strong support for the prognostic and diagnostic properties of the miRNA panel in SSc.

MIRASYS has been designed to accelerate the commercialisation of a panel of highly potent miRNAs that have breakthrough diagnostic potential in SSc. MIRASYS will be used to validate these findings by setting miRNA expression level boundaries for SSc development and to incorporate these in a diagnostic assay. MIRASYS will also assess the commercial feasibility of setting-up a dedicated spin-off company to commercialise the technology. The team has analysed the IP landscape for similar approaches for SSc and no prior art on the specific miRNAs was found. In the MIRASYS ERC PoC Grant, the team will further investigate the IP position and formulate a strong IP strategy including the steps towards full Freedom to Operate.

The MIRASYS team consists of experienced science and business professionals. The team has developed several business models which need to be assessed thoroughly through in-depth market research. The results need to be consolidated into a strong business plan that will be presented to investors and strategic investors.

 Publications

year authors and title journal last update
List of publications.
2017 Marzia Rossato, Alsya J. Affandi, Soley Thordardottir, Catharina G. K. Wichers, Marta Cossu, Jasper C. A. Broen, Frederique M. Moret, Lara Bossini-Castillo, Eleni Chouri, Lenny van Bon, Femke Wolters, Wioleta Marut, Maarten van der Kroef, Sandra Silva-Cardoso, Cornelis P. J. Bekker, Harry Dolstra, Jacob M. van Laar, Javier Martin, Joel A. G. van Roon, Kris A. Reedquist, Lorenzo Beretta, Timothy R.
Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis
published pages: 1891-1902, ISSN: 2326-5191, DOI: 10.1002/art.40163 		Arthritis & Rheumatology 69/9 2019-07-26

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The information about "MIRASYS" are provided by the European Opendata Portal: CORDIS opendata.

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