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PANA SIGNED

PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PANA project word cloud

Explore the words cloud of the PANA project. It provides you a very rough idea of what is the project "PANA" about.

implying molecular theranostic oligomers strategies hospitals experts smart neuroscientists clinicians multifunctional defeat dementia tau medium magnitude detection accessible tissue recognize enhanced engineered nanotechnologists gaining strategy pet relevance theragnostic autonomy therapeutic elderly detected characterization nanostructures limitation multimodal advantages bases pillars solution action social mri enterprises aging delaying imaging medical effort ad combining situ tools diagnosis urgent population alzheimer symptoms fundamental progressive decades brain pathophysiological vital biomaterial diagnostic technologies invasive markers combines complementary pana decline nanoparticles disease agents sensitivity appearance structural techniques efforts small purposes cognitive adverse

Project "PANA" data sheet

The following table provides information about the project.

Coordinator	SERVIZO GALEGO DE SAUDE Organization address address: Edificio Administrativo San Lázaro city: Santiago de Compostela postcode: 15703 website: www.sergas.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://panaproject.eu/
Total cost	7˙775˙972 €
EC max contribution	7˙775˙972 € (100%)
Programme	1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
Code Call	H2020-NMP-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2021-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SERVIZO GALEGO DE SAUDE SERVIZO GALEGO DE SAUDE Organization address address: Edificio Administrativo San Lázaro city: Santiago de Compostela postcode: 15703 website: www.sergas.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Santiago de Compostela)	coordinator	1˙573˙537.00
2	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	1˙094˙875.00
3	ITA-SUOMEN YLIOPISTO ITA-SUOMEN YLIOPISTO Organization address address: YLIOPISTONRANTA 1 E city: KUOPIO postcode: 70211 website: www.uef.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (KUOPIO)	participant	1˙055˙500.00
4	BIOTECHPHARMA BIOTECHPHARMA Organization address address: MOKSLININKU STREET 4 city: VILNIUS postcode: LT-08412 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LT (VILNIUS)	participant	845˙250.00
5	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	762˙125.00
6	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	participant	529˙750.00
7	reMYND NV reMYND NV Organization address address: Gaston Geenslaan 1 city: LEUVEN postcode: 3001 website: www.remynd.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	482˙720.00
8	STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA Organization address address: RUA DOS INVENTORES S/N EDIFICIO MADAN PARQUE SALAS 2.18 E 2.19 city: CAPARICA postcode: 2825 182 website: www.stabvida.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (CAPARICA)	participant	463˙030.00
9	FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON Organization address address: PARQUE SANTA CLARA city: SORIA postcode: 42002 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SORIA)	participant	396˙250.00
10	LABORATORIO IBERICO INTERNACIONAL DE NANOTECNOLOGIA LABORATORIO IBERICO INTERNACIONAL DE NANOTECNOLOGIA Organization address address: AVENIDA MESTRE JOSE VEIGA city: BRAGA postcode: 4715-330 website: www.inl.int contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (BRAGA)	participant	319˙497.00
11	ROCHE DIAGNOSTICS SL ROCHE DIAGNOSTICS SL Organization address address: AVDA. GENERALITAT SN S CUGAT VALL city: BARCELONA postcode: 8174 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	253˙437.00

Map

Project objective

Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and limitation of social activities. Progressive aging of EU population will increase the magnitude of this problem in the next decades. Currently, there is not an effective method for the early diagnosis of AD. Therefore, there is an urgent need to develop new effective early diagnostic and therapeutic strategies to help in delaying the appearance of the most adverse symptoms of this disease. To defeat this challenge, PANA project bases its approach on the importance of tau oligomers in the early pathophysiological processes of AD. The effective strategy will be based on two fundamental pillars; on one hand, efforts will be focused on multimodal PET/MRI imaging which is gaining relevance as the best solution for diagnostic purposes due to the complementary advantages of both technologies, combining the high structural characterization of tissue provided by MRI with the enhanced sensitivity of PET imaging. On the other hand, the challenging development of a theragnostic nanostructures will be focused on tau oligomers detection, which would have to deliver theragnostic agents into the brain to provide in situ diagnostic and therapeutic effects. Therefore, PANA project focuses on developing theranostic nanostructures that specifically recognize very-early molecular markers of AD, and can be detected by means of non-invasive imaging methodologies (MRI and/or PET, which are already common techniques accessible in most hospitals) and eventually provide a therapeutic action if needed. To achieve this goal, we propose a unique consortium which combines neuroscientists, nanotechnologists, molecular imaging experts, clinicians and Small/Medium/Large Enterprises in an effort to use smart nanoparticles engineered with multifunctional biomaterial to provide new very-early diagnostic tools for AD, a vital medical/social problem in EU.

Deliverables

List of deliverables.
Dissemination material (version 1)	Documents, reports	2020-03-11 12:30:53
Dissemination and communication plan	Documents, reports	2020-03-11 12:30:53
Project web site	Documents, reports	2020-03-11 12:30:53

Take a look to the deliverables list in detail: detailed list of PANA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	AdriÃ¡n Posado FernÃ¡ndez In the Siege of AlzheimerÂ´s Castle: Contribution to Immunotherapy published pages: , ISSN: , DOI:		2020-03-11
2019	Kristof Govaerts, Benoit Lechat, Tom Struys, Anna Kremer, Peter Borghgraef, Fred Van Leuven, Uwe Himmelreich, Tom Dresselaers Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer\'s disease with amyloid and tau pathology published pages: e4037, ISSN: 0952-3480, DOI: 10.1002/nbm.4037	NMR in Biomedicine 32/2	2020-03-11
2019	Zulema Vargas-Osorio, AndrÃ©s Da Silva-Candal, Yolanda PiÃ±eiro, RamÃ³n Iglesias-Rey, Tomas Sobrino, Francisco Campos, JosÃ© Castillo, JosÃ© Rivas Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications published pages: 449, ISSN: 2079-4991, DOI: 10.3390/nano9030449	Nanomaterials 9/3	2020-03-11
2019	Zulema Vargas-Osorio, Asteria Luzardo-Ãlvarez, Yolanda PiÃ±eiro, Carlos VÃ¡zquez-VÃ¡zquez, J. Luis GÃ³mez-Amoza, JosÃ© Blanco-MÃ©ndez, Francisco J. Otero Espinar, JosÃ© Rivas Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility published pages: 5496-5508, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b03676	ACS Omega 4/3	2020-03-11
2018	Lynn van Olst, Pascal Bielefeld, Carlos P. Fitzsimons, Helga E. de Vries, Marijn Schouten Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia published pages: e12790, ISSN: 1474-9718, DOI: 10.1111/acel.12790	Aging Cell 17/4	2020-03-11
2018	Rita Sofia Garcia Ribeiro, Conny Gysemans, JoÃ£o Paulo Monteiro Carvalho Mori da Cunha, Bella B. Manshian, Daniel Jirak, Jan Kriz, Juan Gallo, Manuel BaÃ±obre-LÃ³pez, Tom Struys, Marcel De Cuyper, Chantal Mathieu, Stefaan J. Soenen, Willy Gsell, Uwe Himmelreich Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29136-9	Scientific Reports 8/1	2020-03-11
2019	Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, AdriÃ¡n Posado-FernÃ¡ndez, Simo RyhÃ¤nen, Petra MÃ¤kinen, Kaisa M.A. Paldanius, GonÃ§alo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltunen Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice published pages: 98-108, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.11.008	Neurobiology of Aging 75	2020-03-11

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