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REGDAM

REGULATORY T CELLS AND TISSUE DAMAGE CONTROL

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

REGDAM project word cloud

Explore the words cloud of the REGDAM project. It provides you a very rough idea of what is the project "REGDAM" about.

immune dysfunction oxidative impacting immunity fellowship innate limits regulatory cellular dampen stress output ill exposed tested preserve central modulates modulate mechanistically outputs inflammatory adaptive critical marie pathogenesis imposed treg tissues hypoxic hypothesis mediated parenchyma players cells resident functional exerted later curie receive signals migrate deleterious exacerbate forms tissue effect damage mechanism diseases inflammation protective

Project "REGDAM" data sheet

The following table provides information about the project.

Coordinator	FUNDACAO CALOUSTE GULBENKIAN Organization address address: AVENIDA BERNA 45 city: LISBOA postcode: 1000 website: www.igc.gulbenkian.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	148˙635 €
EC max contribution	148˙635 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2019-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACAO CALOUSTE GULBENKIAN FUNDACAO CALOUSTE GULBENKIAN Organization address address: AVENIDA BERNA 45 city: LISBOA postcode: 1000 website: www.igc.gulbenkian.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	148˙635.00

Map

Project objective

Regulatory T cells (TREG) are critical players in the control of innate and adaptive immune responses while impacting as well on the functional output of parenchyma tissues. This later effect is exerted by tissue-resident TREG, via an ill-defined mechanism that modulates tissue damage control, that is, a protective response of parenchyma tissues that limits cellular dysfunction and/or damage imposed by inflammation and immunity. The central hypothesis to be tested under this proposal is that tissue-resident TREG modulate tissue damage control via a number of adaptive responses to cellular stress, which preserve the functional outputs of parenchyma tissues. Failure of tissue-resident TREG to modulate adaptive responses to oxidative and hypoxic stress should exacerbate the deleterious effects imposed by these forms of stress on parenchyma cells and as such promote the pathogenesis of immune mediated inflammatory diseases. Under this Marie-Curie fellowship we will address mechanistically how TREG receive signals from tissues exposed to oxidative and hypoxic stress and migrate to those tissues to modulate oxidative and hypoxic stress responses as to dampen tissue damage.

Publications

List of publications.
year	authors and title	journal	last update
2019	Birte Blankenhaus, Faouzi Braza, Rui Martins, Patricia Bastos-Amador, Ismael GonzÃ¡lez-GarcÃa, Ana Rita Carlos, InÃªs Mahu, Pedro Faisca, Jose Moura Nunes, Pedro Ventura, Verena Hoerr, Sebastian Weis, Joel Guerra, Silvia Cardoso, Ana Domingos, Miguel LÃ³pez, Miguel P. Soares Ferritin regulates organismal energy balance and thermogenesis published pages: 64-79, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2019.03.008	Molecular Metabolism 24	2019-09-17
2019	Rui Martins, Ana Rita Carlos, Faouzi Braza, Jessica A. Thompson, Patricia Bastos-Amador, Susana Ramos, Miguel P. Soares Disease Tolerance as an Inherent Component of Immunity published pages: 405-437, ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-042718-041739	Annual Review of Immunology 37/1	2019-09-17
2019	Susana Ramos, Ana Rita Carlos, Balamurugan Sundaram, Viktoria Jeney, Ana Ribeiro, Raffaella Gozzelino, Claudia Bank, Erida Gjini, Faouzi Braza, Rui Martins, Temitope Wilson Ademolue, Birte Blankenhaus, ZÃ©lia Gouveia, Pedro FaÃsca, Damian Trujillo, SÃlvia Cardoso, Sofia Rebelo, Laura del Barrio, Abolfazl Zarjou, Subhashini Bolisetty, Anupam Agarwal, Miguel P. Soares Renal control of disease tolerance to malaria published pages: 5681-5686, ISSN: 0027-8424, DOI: 10.1073/pnas.1822024116	Proceedings of the National Academy of Sciences 116/12	2019-09-17

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