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NEURAM SIGNED

Visual genetics: establishment of a new discipline to visualize neuronal nuclear functions in real-time in intact nervous system by 4D Raman spectroscopy

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

NEURAM project word cloud

Explore the words cloud of the NEURAM project. It provides you a very rough idea of what is the project "NEURAM" about.

nucleosides temporal stimulated widening resolution limitation technologies types cell utilized possibility organisms labelling track edge offers scientific broad treat of therapeutic institutes nuclear cutting visualize behavior transcription dysfunctions toxicity commercialise 4d free stage prototype endogenous srs understand gene organization seriously disease functional living basis intervene analogues tagged provides neural diseases options loading visualization tech structural constraints medical distinguish observation microscope brain nervous possibilities nucleotide intact spatial diagnosis detection cancer diagnose link technique label neurons single functioning tools mapping human time spectroscopy feasible run unknown neuron raman cure due genetic constrained networks overcome alkyne deep transcriptional function symptoms combination

Project "NEURAM" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://neuram.eu/
Total cost	4˙271˙481 €
EC max contribution	4˙271˙481 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2014-2015-RIA
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	coordinator	722˙316.00
2	FEMTONICS KUTATO ES FEJLESZTO KORLATOLT FELELOSSEGU TARSASAG FEMTONICS KUTATO ES FEJLESZTO KORLATOLT FELELOSSEGU TARSASAG Organization address address: TUZOLTO UTCA 59 city: BUDAPEST postcode: 1094 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	1˙858˙711.00
3	WIGNER FIZIKAI KUTATOKOZPONT WIGNER FIZIKAI KUTATOKOZPONT Organization address address: Konkoly Thege Miklos ut 29-33 city: Budapest postcode: 1121 website: www.wigner.mta.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (Budapest)	participant	712˙250.00
4	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	711˙000.00
5	PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS Organization address address: VASVARI PAL UTCA 4 city: PECS postcode: 7622 website: www.pte.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (PECS)	participant	267˙203.00

Map

Project objective

Due to technical constraints the observation and analysis of endogenous transcriptional processes in living and functioning organisms is not feasible today. Therefore our understanding of the nuclear processes and the options to diagnose or intervene at genetic level is seriously constrained. Our proposal offers a cutting-edge technique to overcome this limitation. The aim is to visualize nuclear processes in intact brain in real-time leading to a new high-tech product development, prototype scientific equipment at the research institutes and in the long run new tools to study and cure human diseases. The main objectives are to: 1) develop Stimulated Raman Spectroscopy (SRS)-based technologies to visualize endogenous transcription at single cell and single gene level; 2) develop tools for loading alkyne-tagged nucleosides and nucleotide analogues into neurons; 3) distinguish neuron types without labelling by SRS; 4) track transcription processes in intact brain with high temporal and spatial resolution; 5) study link between single gene function and behavior; 5) develop and commercialise a 4D-SRS microscope for broad range of applications. The combination of label-free neuron mapping and visualization of nuclear activity at single gene level provides a new level of information of the structural and functional organization of the brain. The genetic basis of most of the brain diseases is still unknown. Widening genetic knowledge of brain diseases will offer as yet unknown therapeutic possibilities. Understanding the neural processes at the genetic level offer the possibility to intervene at that deep level, targeting not only the symptoms but the cause. The proposed novel technology provides new insight to understand neural networks and is a key to understand and treat nervous system dysfunctions. The 4D-SRS systems can be utilized for other medical-based research and development projects aimed at early stage disease diagnosis, cancer detection, and toxicity studies.

Deliverables

List of deliverables.
Action check meeting 1	Documents, reports	2019-05-31 11:58:27
Website	Websites, patent fillings, videos etc.	2019-05-31 11:58:16

Take a look to the deliverables list in detail: detailed list of NEURAM deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Yavor Hadzhiev, Haseeb K. Qureshi, Lucy Wheatley, Ledean Cooper, Aleksandra Jasiulewicz, Huy Van Nguyen, Joseph W. Wragg, Divyasree Poovathumkadavil, Sascha Conic, Sarah Bajan, Attila Sik, GyÃ¶rgy HutvÃ gner, LÃ szlÃ² Tora, Agnieszka Gambus, John S. Fossey, Ferenc MÃ¼ller A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08487-5	Nature Communications 10/1	2019-09-02

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The information about "NEURAM" are provided by the European Opendata Portal: CORDIS opendata.

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