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TREATMENT SIGNED

Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TREATMENT project word cloud

Explore the words cloud of the TREATMENT project. It provides you a very rough idea of what is the project "TREATMENT" about.

predictive toxicology medicine diseases empower young subsequently multidisciplinary biomarkers national drugs care innovative tool dysfunctions unexplored kits network public tools urgently marie employability evaluation sklodowska treatments combines career validate metabolic decrease medical secondary antipsychotic metabolism interventions trigger paths ultimate treatment negative validation limitations severe drug disorders strategy intersectorial pharmacology clinically commercial added health trans life marker mental risk strategies sectors training curie patients pharmacological regimens medications effort private chronic adverse academic scientists personalized adherence

Project "TREATMENT" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://itn-treatment.eu/
Total cost	3˙750˙898 €
EC max contribution	3˙750˙898 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	991˙491.00
2	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	527˙318.00
3	THE HEBREW UNIVERSITY OF JERUSALEM THE HEBREW UNIVERSITY OF JERUSALEM Organization address address: EDMOND J SAFRA CAMPUS GIVAT RAM city: JERUSALEM postcode: 91904 website: www.huji.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (JERUSALEM)	participant	520˙601.00
4	CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO Organization address address: UNIVERSIDADE DE COIMBRA, LARGO DE POMBAL city: COIMBRA postcode: 3004 517 website: www.cnbc.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (COIMBRA)	participant	476˙712.00
5	CELL STRESS DISCOVERIES LIMITED CELL STRESS DISCOVERIES LIMITED Organization address address: UNIT 204, NUIG BUSINESS INNOVATION CENTRE, NEWCASTLE ROAD city: GALWAY postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (GALWAY)	participant	265˙674.00
6	FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO LA PRINCESA FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO LA PRINCESA Organization address address: DIEGO DE LEON 62 1 PLANTA city: MADRID postcode: 28006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	247˙872.00
7	NIMGENETICS, GENOMICA Y MEDICINA S.L. NIMGENETICS, GENOMICA Y MEDICINA S.L. Organization address address: CALLE FARADAY 7 city: MADRID postcode: 28049 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	247˙872.00
8	BNML BEHAVIORAL & MOLECULAR LAB BNML BEHAVIORAL & MOLECULAR LAB Organization address address: CAMPUS DE GUALTAR city: BRAGA postcode: 4510-057 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (BRAGA)	participant	238˙356.00
9	UNIVERZA V LJUBLJANI UNIVERZA V LJUBLJANI Organization address address: KONGRESNI TRG 12 city: LJUBLJANA postcode: 1000 website: http://www.uni-lj.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	234˙997.00
10	ANAXOMICS BIOTECH SL ANAXOMICS BIOTECH SL Organization address address: CALLE DIPUTACIO 237, P 1 PTA 1 city: BARCELONA postcode: 8007 website: www.anaxomics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	partner	0.00
11	CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. Organization address address: CALLE MONFORTE DE LEMOS 5 city: MADRID postcode: 28029 website: www.ciberisciii.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	partner	0.00
12	UNIVERSIDAD DE LLEIDA UNIVERSIDAD DE LLEIDA Organization address address: Placa Victor Siurana 1 1 city: LLEIDA postcode: 25003 website: www.udl.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LLEIDA)	partner	0.00

Map

Project objective

TREATMENT is a Marie Sklodowska Curie Innovative Training Network proposal directly addressing the need for high-level training and career paths in risk evaluation of drug induced metabolic dysfunctions, a relevant aspect, so far unexplored by traditional toxicology studies, but urgently needed to challenge current severe limitations of health care interventions in mental disorders. These patients require life-long medications that subsequently trigger metabolic diseases with a strong negative impact on their health and well-being. To achieve this, and improve adherence to treatments, we will evaluate how short-term antipsychotic drug responses impact long-term metabolic control to identify and validate biomarkers with clinically predictive value for targeting drug induced metabolic dysfunctions. This effort will have added commercial value by enabling the design of predictive marker kits for testing adverse secondary metabolic effects of drugs to be used in pharmacological and medical practice. TREATMENT will provide multidisciplinary knowledge, capabilities and tools to implement this ambitious strategy by the training of young scientists in a program that combines pharmacology, metabolism and mental health research with strategies for product and tool design and validation. Our ultimate goal is to empower the intersectorial and trans-national employability of young scientists across academic, public and private sectors to foster the development and implementation of personalized medicine tools that will provide effective treatment regimens for life long health-care interventions and decrease the risk for development of chronic metabolic diseases.

Deliverables

List of deliverables.
Dissemination report 1	Documents, reports	2020-02-25 14:39:42
Research Training schools/Meetings, and reports 3	Documents, reports	2020-02-25 14:39:42
Researchers Declarations	Other	2020-02-25 14:39:42
Open Research Data Pilot	Open Research Data Pilot	2020-02-25 14:39:42
Supervisory Board of the network	Other	2020-02-25 14:39:42

Take a look to the deliverables list in detail: detailed list of TREATMENT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Ignacio Prieto, Carmen Rubio AlarcÃ³n, Raquel GarcÃa-GÃ³mez, Rebeca BerdÃºn, Tamara Urgel, Manuel Portero, Reinald Pamplona, Antonio MartÃnez-Ruiz, JosÃ© Ignacio Ruiz-Sanz, M. BegoÃ±a Ruiz-Larrea, Mariona Jove, SebastiÃ¡n CerdÃ¡n, MarÃa Monsalve Metabolic adaptations in spontaneously immortalized PGC-1Î± knock-out mouse embryonic fibroblasts increase their oncogenic potential published pages: 101396, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101396	Redox Biology 29	2020-03-06
2019	Ignacio Prieto, Alberto Zambrano, Javier Laso, Ana Aranda, Enrique Samper, MarÃa Monsalve Early induction of senescence and immortalization in PGC-1Î±-deficient mouse embryonic fibroblasts published pages: 23-32, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.04.015	Free Radical Biology and Medicine 138	2020-03-06
2019	Dora Koller, Pablo Zubiaur, Miriam Saiz-RodrÃguez, Francisco Abad-Santos, Aneta Wojnicz Simultaneous determination of six antipsychotics, two of their metabolites and caffeine in human plasma by LC-MS/MS using a phospholipid-removal microelution-solid phase extraction method for sample preparation published pages: 159-168, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2019.01.112	Talanta 198	2020-03-06
2020	Akram Obiedat, Yoav Charpak-Amikam, Julie Tai-Schmiedel, Einat Seidel, Mohamed Mahameed, Tony Avril, Noam Stern-Ginossar, Lorraine Springuel, Jennifer BolsÃ©e, David E. Gilham, Priya Dipta, Miriam Shmuel, Eric Chevet, Ofer Mandelboim, Boaz Tirosh The integrated stress response promotes B7H6 expression published pages: 135-148, ISSN: 0946-2716, DOI: 10.1007/s00109-019-01859-w	Journal of Molecular Medicine 98/1	2020-03-06
2019	Anja Å oÅ¡tariÄ, Barbara Jenko, Nada Rotovnik Kozjek, Darja OvijaÄ, DuÅ¡an Å uput, Irina Milisav, Vita DolÅ¾an Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention published pages: 1184-1194, ISSN: 1734-1922, DOI: 10.5114/aoms.2019.87462	Archives of Medical Science 15/5	2020-02-25
2020	Vitor Ferreira, Diana Grajales, Ãngela M. Valverde Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view published pages: 158534, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2019.158534	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865/2	2020-02-25
2019	Izak Patrik Miller, Ivan PavloviÄ‡, Borut PoljÅ¡ak, DuÅ¡an Å uput, Irina Milisav Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival published pages: 434, ISSN: 2076-3921, DOI: 10.3390/antiox8100434	Antioxidants 8/10	2020-02-25
2019	Diana Grajales, Vitor Ferreira, Ãngela M. Valverde Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain published pages: 1336, ISSN: 2073-4409, DOI: 10.3390/cells8111336	Cells 8/11	2020-02-25
2018	M.C. Ovejero-Benito, P. SÃ¡nchez-JimÃ©nez, M. Saiz-RodrÃguez, S. MartÃn-Vilchez, T. Cabaleiro, M. RomÃ¡n, D. Ochoa, F. Abad-Santos, A. Reolid, E. MuÃ±oz-Aceituno, M. Llamas-Velasco, E. DaudÃ©n, F. Abad-Santos Histone modifications associated with nonconventional systemic drug response in moderate-to-severe psoriasis. published pages: , ISSN: 2531-0151, DOI: 10.24217/2531-0151.18v1s1.00007	IBJ Plus	2020-02-25
2018	M. Pilar Valdecantos, Laura Ruiz, Virginia Pardo, Luis Castro-Sanchez, Carmelo GarcÃa-MonzÃ³n, Borja LanzÃ³n, Javier RupÃ©rez, Coral Barbas, Jaqueline Naylor, James L. Trevaskis, Joseph Grimsby, Cristina M. Rondinone, Ãngela M. Valverde Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33949-z	Scientific Reports 8/1	2020-02-25
2019	Alessandra Stacchiotti, Ilaria Grossi, Raquel GarcÃa-GÃ³mez, Gaurangkumar Arvindbhai Patel, Alessandro Salvi, Antonio Lavazza, Giuseppina De Petro, Maria Monsalve, Rita Rezzani Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy published pages: 1053, ISSN: 2073-4409, DOI: 10.3390/cells8091053	Cells 8/9	2020-02-25
2018	Miriam Saiz-RodrÃguez, Dolores Ochoa, Coral Herrador, Carmen Belmonte, Manuel RomÃ¡n, Enrique Alday, Dora Koller, Pablo Zubiaur, Gina MejÃa, MarÃa HernÃ¡ndez-MartÃnez, Francisco Abad-Santos Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects published pages: , ISSN: 1742-7835, DOI: 10.1111/bcpt.13141	Basic & Clinical Pharmacology & Toxicology	2020-02-25
2018	CatÃa Marques, Assel Sarsenbayeva, Gretha Boersma, Maria JoÃ£o Pereira, Jan Eriksson, Angela Valverde, Angela Valverde, EugÃ©nia Carvalho Effects of olanzapine and aripiprazole on glucose uptake in healthy human subcutaneous adipocytes during short incubations. published pages: , ISSN: 2531-0151, DOI: 10.24217/2531-0151.18v1s1.00008	IBJ Plus	2020-02-25
2018	Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Maria Monsalve, Luigi Rodella, Rita Rezzani Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney published pages: 689, ISSN: 2072-6643, DOI: 10.3390/nu10060689	Nutrients 10/6	2020-02-25
2018	Miriam Saiz-RodrÃguez, Daniel Romero-PalaciÃ¡n, Carlos Villalobos-Vilda, JosÃ© Luis Caniego, Carmen Belmonte, Dora Koller, Eduardo BÃ¡rcena, MarÃa TalegÃ³n, Francisco Abad-Santos Influence of CYP2C19 Phenotype on the Effect of Clopidogrel in Patients Undergoing a Percutaneous Neurointervention Procedure published pages: , ISSN: 0009-9236, DOI: 10.1002/cpt.1067	Clinical Pharmacology & Therapeutics	2020-02-25
2019	Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia MaraÃ±Ã³n, Ana I. Arroba, Beatriz SantamarÃa, Jorge SÃ¡iz, Francisco J. RupÃ©rez, Coral Barbas, Carmelo GarcÃa-MonzÃ³n, Ãngela M. Valverde, Ãgueda GonzÃ¡lez-RodrÃguez Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury published pages: dmm038810, ISSN: 1754-8403, DOI: 10.1242/dmm.038810	Disease Models & Mechanisms 12/7	2020-02-25
2019	Assel Sarsenbayeva, CÃ¡tia M. Marques-Santos, Ketan Thombare, Giada Di Nunzio, Kristina E. Almby, Martin Lundqvist, Jan W. Eriksson, Maria J. Pereira Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism published pages: 104445, ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2019.104445	Psychoneuroendocrinology	2020-02-25
2018	Elena Alcalde-EstÃ©vez, Ana I. Arroba, Elena M. SÃ¡nchez-FernÃ¡ndez, Carmen Ortiz Mellet, Jose M. GarcÃa FernÃ¡ndez, Laura Masgrau, Ãngela M. Valverde The sp 2 -iminosugar glycolipid 1-dodecylsulfonyl-5 N ,6 O -oxomethylidenenojirimycin (DSO 2 -ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants published pages: 454-466, ISSN: 0278-6915, DOI: 10.1016/j.fct.2017.11.050	Food and Chemical Toxicology 111	2020-02-25
2018	Dora Koller, Carmen Belmonte, Rubin Lubomirov, Miriam Saiz-RodrÃguez, Pablo Zubiaur, Manuel RomÃ¡n, Dolores Ochoa, Antonio Carcas, Aneta Wojnicz, Francisco Abad-Santos Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects published pages: 1212-1222, ISSN: 0269-8811, DOI: 10.1177/0269881118798605	Journal of Psychopharmacology 32/11	2020-02-25
2017	M Morais, P PatrÃcio, A Mateus-Pinheiro, N D Alves, A R Machado-Santos, J S Correia, J Pereira, L Pinto, N Sousa, J M Bessa The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression published pages: e1146, ISSN: 2158-3188, DOI: 10.1038/tp.2017.120	Translational Psychiatry 7/6	2020-02-25
2019	Inmaculada GarcÃa-Ruiz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruiz, Ana Blas-GarcÃa, M. Pilar Valdecantos, Montserrat Grau Sanz, JosÃ© A. SolÃs Herruzo, Ãngela M. Valverde Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases published pages: 101263, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101263	Redox Biology 26	2020-02-25
2018	Ana I. Arroba, Antonio Campos-Caro, Manuel Aguilar-Diosdado, Ãngela M. Valverde IGF-1, Inflammation and Retinal Degeneration: A Close Network published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2018.00203	Frontiers in Aging Neuroscience 10	2020-02-25
2018	Miriam Saiz-RodrÃguez, Carmen Belmonte, Manuel RomÃ¡n, Dolores Ochoa, Carolina Jiang-Zheng, Dora Koller, Gina MejÃa, Pablo Zubiaur, Aneta Wojnicz, Francisco Abad-Santos Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants published pages: 474-485, ISSN: 1742-7835, DOI: 10.1111/bcpt.13031	Basic & Clinical Pharmacology & Toxicology 123/4	2020-02-25
2018	Marina Mojena, MarÃa Pimentel-Santillana, AdriÃ¡n Povo-Retana, Victoria FernÃ¡ndez-GarcÃa, Silvia GonzÃ¡lez-Ramos, Patricia Rada, Alberto Tejedor, Daniel Rico, Paloma MartÃn-Sanz, Angela M. Valverde, Lisardo BoscÃ¡ Protection against gamma-radiation injury by protein tyrosine phosphatase 1B published pages: 213-223, ISSN: 2213-2317, DOI: 10.1016/j.redox.2018.04.018	Redox Biology 17	2020-02-25
2019	Martin H. Lundqvist, Kristina Almby, Niclas Abrahamsson, Jan W. Eriksson Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes? published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00457	Frontiers in Physiology 10	2020-02-25
2019	Å pela Å alamon, Barbara Kramar, Tinkara Pirc Marolt, Borut PoljÅ¡ak, Irina Milisav Medical and Dietary Uses of N-Acetylcysteine published pages: 111, ISSN: 2076-3921, DOI: 10.3390/antiox8050111	Antioxidants 8/5	2020-02-25
2018	Ãgueda GonzÃ¡lez-RodrÃguez, M. Pilar Valdecantos, Patricia Rada, Annalisa Addante, InÃ©s Barahona, Esther Rey, Virginia Pardo, Laura Ruiz, Laura M. Laiglesia, MarÃa J. Moreno-Aliaga, Carmelo GarcÃa-MonzÃ³n, ArÃ¡nzazu SÃ¡nchez, Ãngela M. Valverde Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis published pages: 132-146, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.10.008	Molecular Metabolism 7	2020-02-25

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