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ArrestAD SIGNED

3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

ArrestAD project word cloud

Explore the words cloud of the ArrestAD project. It provides you a very rough idea of what is the project "ArrestAD" about.

clinics transcriptomics science molecular prevention internalized spreading heparan sme alzheimer candidates pathology enzymology species cells interactomics arrestad diverse neurodegeneration upec citizens brings class accumulation society socio economic treatment visionary initial underpinning gain arresting altered carbohydrate drug detection genetics central ad kits character classic economy neurons benefit beta phosphorylation offset multidisciplinary joint vision proposes experts thinking hallmarks demonstration interaction traffic diagnosis links generate preventing circulating sulfate aggregation technologies refining experimentation risk internationally specialized abnormal 2 disease animal ing intracellular cure tau societal triggered models portfolio seeding biology nature sulfates cell radically chemistry nor proving strategies demonstrating

Project "ArrestAD" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE PARIS XII VAL DE MARNE Organization address address: AVENUE DU GENERAL DE GAULLE 61 city: CRETEIL postcode: 94010 website: www.univ-paris12.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	https://arrestad.wordpress.com/
Total cost	3˙991˙096 €
EC max contribution	3˙991˙096 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE PARIS XII VAL DE MARNE UNIVERSITE PARIS XII VAL DE MARNE Organization address address: AVENUE DU GENERAL DE GAULLE 61 city: CRETEIL postcode: 94010 website: www.univ-paris12.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CRETEIL)	coordinator	891˙181.00
2	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	579˙250.00
3	INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK Organization address address: UL. LUDWIKA PASTEURA 3 city: WARSZAWA postcode: 02 093 website: www.nencki.gov.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (WARSZAWA)	participant	518˙125.00
4	FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA Organization address address: Campus Miguel de Unamuno city: SALAMANCA postcode: 37007 website: www.cicancer.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SALAMANCA)	participant	452˙375.00
5	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	400˙625.00
6	UNIVERSIDAD AUTONOMA DE BARCELONA UNIVERSIDAD AUTONOMA DE BARCELONA Organization address address: CALLE CAMPUS UNIVERSITARIO SN CERDANYOLA V city: CERDANYOLA DEL VALLES postcode: 8290 website: http://www.uab.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CERDANYOLA DEL VALLES)	participant	394˙875.00
7	ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ASSISTANCE PUBLIQUE HOPITAUX DE PARIS Organization address address: 3 AVENUE VICTORIA city: PARIS postcode: 75000 website: http://www.aphp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	383˙540.00
8	SCREENCELL SCREENCELL Organization address address: 10 AVENUE CHARLES PEGUY CENTRE ROGER PEREZ city: SARCELLES postcode: 95200 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SARCELLES)	participant	371˙125.00

Map

Project objective

ArrestAD proposes a novel and visionary thinking resulting from the demonstration of the central role of a particular heparan sulfate species at the intracellular level in neurons and in circulating cells in the molecular pathology of Alzheimer’s disease (AD). AD is a societal challenge for which there is neither prevention nor possible cure. Research in the field has long been refining classic concepts based on the aggregation of Aβ and tau through initial seeding and then spreading. Our vision is different and based on the demonstration that tau abnormal phosphorylation and aggregation is triggered by the interaction of tau with heparan sulfates internalized in neurons and circulating cells only in AD [UPEC R.1; P.1,2]. Based in this new concept, ArrestAD will establish links between AD genetics, disease hallmarks, and altered traffic and intracellular accumulation of heparan sulfates to generate new knowledge underpinning the development of new strategies for detection and treatment of AD. This will open to radically new technologies addressing two major objectives: 1) proving that specific and early diagnosis of AD is possible in circulating cells, and 2) demonstrating that a new class of drug candidates are able to preventing and/or arresting AD-neurodegeneration. To reach these objectives, ArrestAD brings together internationally recognized experts in AD clinics and diagnosis, in heparan sulfate biology, transcriptomics, interactomics, carbohydrate chemistry, enzymology, cell biology, animal experimentation with AD models, and a SME specialized in the development of diagnosis kits using circulating cells. The high-risk character of this joint science and technology research is offset by the multidisciplinary nature of the Consortium and the high socio-economic gain resulting from success. Based in this technology, we will build a diverse portfolio of future projects that will result in a long-term benefit for citizens, economy and society.

Deliverables

List of deliverables.
Listing RNA and protein extracts from AD	Documents, reports	2020-02-19 17:34:49
Data management Plan	Open Research Data Pilot	2020-02-19 17:34:49
Dissemination and exploitation plan	Documents, reports	2020-02-19 17:34:49
Cohorts description	Documents, reports	2020-02-19 17:34:49
Website and Communication tools	Websites, patent fillings, videos etc.	2020-02-19 17:34:48

Take a look to the deliverables list in detail: detailed list of ArrestAD deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Oscar GonzÃ¡lez-Velasco, Dulce Papy-GarcÃa, Gael Le Douaron, JosÃ© M. SÃ¡nchez-Santos, Javier De Las Rivas Transcriptomic landscape, gene signatures and regulatory profile of aging in the human brain published pages: 194491, ISSN: 1874-9399, DOI: 10.1016/j.bbagrm.2020.194491	Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms	2020-03-11
2019	Neil M. Kershaw, Dominic P. Byrne, Hollie Parsons, Neil G. Berry, David G. Fernig, Patrick A. Eyers, Richard Cosstick Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors published pages: 32165-32173, ISSN: 2046-2069, DOI: 10.1039/c9ra07567d	RSC Advances 9/55	2020-02-19
2019	Bui TP, Li Y, Ngamlert P, Nunes QM, Wilkinson MC and Fernig DG Selective labelling of arginine residues engaged in binding sulfated glycosaminoglycans published pages: , ISSN: , DOI: 10.1101/574947	bioRxiv	2020-02-19
2017	C. Vera, J.A. Ãlvarez-Orozco, A. MaÃ¯za, S. Chantepie, R.N. ChehÃn, M.O. Ouidja, D. Papy-Garcia [Heparan sulphates, amyloidosis and neurodegeneration] published pages: 457-468, ISSN: 0210-0010, DOI:	Revista de neurologia 65	2020-02-19
2018	Joanna Wojsiat, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda Oxidant/Antioxidant Imbalance in Alzheimerâ€™s Disease: Therapeutic and Diagnostic Prospects published pages: 1-16, ISSN: 1942-0900, DOI: 10.1155/2018/6435861	Oxidative Medicine and Cellular Longevity 2018	2020-02-19
2017	Toin H. van Kuppevelt, Arie Oosterhof, Elly M. M. Versteeg, Emina Podhumljak, Els M. A. van de Westerlo, Willeke F. Daamen Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions published pages: 14785, ISSN: 2045-2322, DOI: 10.1038/s41598-017-15009-0	Scientific Reports 7/1	2020-02-19
2018	Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors published pages: 2435-2455, ISSN: 0264-6021, DOI: 10.1042/bcj20180266	Biochemical Journal 475/15	2020-02-19
2018	Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, DulcÃ© Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors published pages: 2417-2433, ISSN: 0264-6021, DOI: 10.1042/BCJ20180265	Biochemical Journal 475/15	2020-02-19
2019	Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane MaÃ¯za, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garcia Glycosaminoglycans from Alzheimerâ€™s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau published pages: e0209573, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0209573	PLOS ONE 14/1	2020-02-19
2018	Auriane MaÃ¯za, Sandrine Chantepie, Cecilia Vera, Alexandre Fifre, Minh Bao Huynh, Olivier Stettler, Mohand Ouidir Ouidja, Dulce Papyâ€Garcia The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration published pages: 3806-3818, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13082	FEBS Letters 592/23	2020-02-19
2019	Siranjeevi Nagaraj, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda microRNA diagnostic panel for Alzheimerâ€™s disease and epigenetic trade-off between neurodegeneration and cancer published pages: 125-143, ISSN: 1568-1637, DOI: 10.1016/j.arr.2018.10.008	Ageing Research Reviews 49	2020-02-19
2018	Raquel Baeta-Corral, Rafael Castro-Fuentes, Lydia GimÃ©nez-Llort Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging published pages: 1147-1157, ISSN: 1079-5006, DOI: 10.1093/gerona/gly031	The Journals of Gerontology: Series A 73/9	2020-02-19

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