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FunKeyGut SIGNED

Illuminating Functional Networks and Keystone Species in the Gut

Total Cost €

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EC-Contrib. €

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Partnership

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 FunKeyGut project word cloud

Explore the words cloud of the FunKeyGut project. It provides you a very rough idea of what is the project "FunKeyGut" about.

situ    rumonicoccus    microspectroscopy    health    discoveries    certain    diverse    elucidated    manipulating    ideal    vital    species    microbial    revealed    disease    microbes    ion    community    immune    catalogue    microbiome    raman    thought    native    identity    networks    training    complexity    keystone    ultimately    largely    functional    provides    bromii    metabolic    protect    treatments    organisms    form    exclusively    unknown    environment    probiotic    gut    breakdown    suited    vitamin    live    communities    symbiosis    intriguing    diet    nanosims    interactions    ideally    shape    exists    competing    infection    reveal    webs    mass    spectrometry    dietary    cooperating    unravel    microbiota    illuminate    outstanding    links    compounds    services    associating    uniquely    function    secondary    food    enteropathogen    rationally    though    labeling    stable    isotope    network    prebiotic    play    human    sequencing    designed    intimate   

Project "FunKeyGut" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://dome.csb.univie.ac.at/research/illuminating-functional-networks-and-keystone-species-in-the-gut-funkeygut
 Total cost 1˙498˙279 €
 EC max contribution 1˙498˙279 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙498˙279.00

Map

 Project objective

We live in an intimate symbiosis with our gut microbiota, which provides us services such as vitamin production, breakdown of dietary compounds, and immune training. Sequencing-based approaches that have been applied to catalogue the gut microbiota have revealed intriguing discoveries associating the microbiome with diet and disease. The next outstanding challenge is to unravel the many activities and interactions that define gut microbiota function.

The gut microbiota is a diverse community of cooperating and competing microbes. These interactions form a network that links organisms with each other and their environment. Interactions in such a “functional network” are based partially, though not exclusively, on food webs. Certain “keystone species”, such as Rumonicoccus bromii, are thought to play a major role in these networks. Though some evidence exists for the presence of keystone species, their identity and activity remains largely unknown. As keystone species are vital to networks they are ideal targets for manipulating the gut microbiota to improve metabolic health and protect against enteropathogen infection.

Given the complexity of the gut microbiota, networks can only be elucidated directly in the native community. This project aims to identify functional networks and keystone species in the human gut using novel approaches that are uniquely and ideally suited for studying microbial activity in complex communities. Using state-of-the-art methods such as stable isotope labeling, Raman microspectroscopy, and secondary ion mass spectrometry (NanoSIMS) we will illuminate functional networks in situ. This will allow us to identify what factors shape gut microbiota activity, reveal important food webs, and ultimately use network knowledge to target the microbiota with prebiotic/probiotic treatments rationally designed to promote health.

 Publications

year authors and title journal last update
List of publications.
2019 Alessandra Riva, Orest Kuzyk, Erica Forsberg, Gary Siuzdak, Carina Pfann, Craig Herbold, Holger Daims, Alexander Loy, Benedikt Warth, David Berry
A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12413-0
Nature Communications 10/1 2019-12-16
2019 Simone Herp, Sandrine Brugiroux, Debora Garzetti, Diana Ring, Lara M. Jochum, Markus Beutler, Claudia Eberl, Saib Hussain, Steffi Walter, Roman G. Gerlach, Hans J. Ruscheweyh, Daniel Huson, Mikael E. Sellin, Emma Slack, Buck Hanson, Alexander Loy, John F. Baines, Philipp Rausch, Marijana Basic, André Bleich, David Berry, Bärbel Stecher
Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis
published pages: 681-694.e8, ISSN: 1931-3128, DOI: 10.1016/j.chom.2019.03.004
Cell Host & Microbe 25/5 2019-12-16
2019 Gomes, Oudot, Macià, Foito, Carregosa, Stewart, Van de Wiele, Berry, Motilva, Brenner, dos Santos
Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota
published pages: 2634, ISSN: 2072-6643, DOI: 10.3390/nu11112634
Nutrients 11/11 2019-12-16
2019 Kang Soo Lee, Márton Palatinszky, Fátima C. Pereira, Jen Nguyen, Vicente I. Fernandez, Anna J. Mueller, Filippo Menolascina, Holger Daims, David Berry, Michael Wagner, Roman Stocker
An automated Raman-based platform for the sorting of live cells by functional properties
published pages: 1035-1048, ISSN: 2058-5276, DOI: 10.1038/s41564-019-0394-9
Nature Microbiology 4/6 2019-12-16
2017 Jesse P. Harrison, David Berry
Vibrational Spectroscopy for Imaging Single Microbial Cells in Complex Biological Samples
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00675
Frontiers in Microbiology 8 2019-10-08

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