Opendata, web and dolomites

BioMeTRe SIGNED

Biophysical mechanisms of long-range transcriptional regulation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 BioMeTRe project word cloud

Explore the words cloud of the BioMeTRe project. It provides you a very rough idea of what is the project "BioMeTRe" about.

functional    restrict    modeling    biology    outputs    enhancer    experiments    associating    biophysical    layer    mechanistic    translate    single    mechanisms    revealed    unknown    cis    mutual    away    formulate    time    sub    testable    models    capture    genes    regulatory    perturbations    details    vivo    linked    entirely    transcriptional    smaller    distal    tuned    principles    sequences    experimental    interpret    tads    population    cells    fine    chromosome    dimensional    relate    confounding    mammals    genomic    promoter    preferential    chromosomal    explore    located    predictions    regulation    structures    hundreds    quantitative    gene    cell    tens    chromatin    showed    megabase    levels    underlying    epigenetics    data    genetic    engineering    link    communication    fiber    enhancers    interactions    conformation    topologically    paradigms    kilobases    structure    relies    cognate    transcription    chromosomes    partitioned    proximity    enzymatic    tad    physical    boundaries    operation    molecular    description    domains    promoters    totally   

Project "BioMeTRe" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 1˙500˙000.00

Map

 Project objective

In mammals, transcriptional control of many genes relies on cis-regulatory elements such as enhancers, which are often located tens to hundreds of kilobases away from their cognate promoters. Functional interactions between distal regulatory elements and target promoters require mutual physical proximity, which is linked to the three-dimensional structure of the chromatin fiber. Chromosome conformation capture studies revealed that chromosomes are partitioned into Topologically Associating Domains (TADs), sub-megabase domains of preferential physical interactions of the chromatin fiber. Genetic evidence showed that TAD boundaries restrict the genomic range of enhancer-promoter communication, and that interactions between regulatory sequences within TADs are further fine-tuned by smaller-scale structures. However, the mechanistic details of how physical interactions translate into transcriptional outputs are totally unknown. Here we propose to explore the biophysical mechanisms that link chromosome conformation and long-range transcriptional regulation using molecular biology, genetic engineering, single-cell experiments and physical modeling. We will measure chromosomal interactions in single cells and in time using a novel method that relies on an enzymatic process in vivo. Genetic engineering will be used to establish a cell system that allows quantitative measurement of how enhancer-promoter interactions relate to transcription at the population and single-cell levels, and to test the effects of perturbations without confounding effects. Finally, we will develop physical models of promoter operation in the presence of distal enhancers, which will be used to interpret the experimental data and formulate new testable predictions. With this integrated approach we aim at providing an entirely new layer of description of the general principles underlying transcriptional control, which could establish new paradigms for research in epigenetics and gene regulation.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIOMETRE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BIOMETRE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

QUBE (2019)

Quantum technology with carbon nanotUBEs

Read More  

AllergenDetect (2019)

Comprehensive allergen detection using synthetic DNA libraries

Read More  

EAST (2020)

Using Evolutionary Algorithms to Understand and Secure Web/Enterprise Systems

Read More