Opendata, web and dolomites

InsularAnxiety SIGNED

Insular cortical circuits controlling fear and anxiety

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 InsularAnxiety project word cloud

Explore the words cloud of the InsularAnxiety project. It provides you a very rough idea of what is the project "InsularAnxiety" about.

awake    guide    viral    predicting    danger    calcium    relying    outcomes    photon    cell    risk    network    plays    mechanistically    integrate    appropriate    influencing    carry    safety    fear    anxiety    body    optogenetic    examine    mouse    overlooked    vivo    signals    processed    bodily    indicates    insular    safe    predicts    advantage    neuronal    imaging    individual    emotions    lab    action    valence    largely    emotional    sensory    connectivity    tools    organization    ultimate    techniques    feelings    decision    insights    behaviour    reveal    expertise    circuit    cues    influences    single    afferents    architecture    environment    cortical    mediating    constantly    express    animals    behavioural    representations    tracing    risky    risks    manipulations    monosynaptic    perspective    optogenetics    dissect    mice    circuits    benefits    amygdala    modern    behaving    cortex    how    function    learned    sufficiency    microcircuits    distributed    behaviours   

Project "InsularAnxiety" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.neuro.mpg.de/gogolla
 Total cost 1˙498˙000 €
 EC max contribution 1˙498˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙498˙000.00

Map

 Project objective

How do emotions guide our behaviour? For an appropriate behavioural response, an individual has to constantly integrate bodily feelings, emotional states, and cues from the environment to evaluate the risks and benefits of a future action. A growing body of evidence indicates that the insular cortex, as part of a distributed neuronal network, plays a key role in influencing emotional behaviour. However, how neuronal circuits within the insular cortex function mechanistically is not known. In this proposal, I will focus on the largely overlooked role of the insular cortex in mediating fear- and anxiety-related behaviours. I will address how the insular cortex processes sensory information of different emotional valence, whether it predicts risk, and how it influences emotional behaviour and decision-making. I will present a research program relying on modern tools to dissect neuronal circuit architecture and function in the mouse, such as viral tracing techniques, optogenetics, behavioural analysis and in vivo two-photon imaging in awake behaving mice.

Taking advantage of the technical expertise of my lab, we will reveal the architecture of connectivity-defined insular cortical microcircuits using monosynaptic viral tracing tools. We will address the necessity and sufficiency of connectivity- and cell-type defined microcircuits to express anxiety and learned safety using optogenetic manipulations. In vivo two-photon calcium imaging in awake behaving animals will allow us to examine how representations of sensory cues predicting danger or safety are processed in the insular cortex, which information amygdala afferents carry to the insular cortex, and whether and how neuronal processing in the insular cortex signals risky or safe outcomes. The ultimate goal of this proposal is to provide novel insights into the function and organization of the insular cortex from a network perspective down to the single cell level.

 Publications

year authors and title journal last update
List of publications.
2019 Daniel A. Gehrlach, Nejc Dolensek, Alexandra S. Klein, Ritu Roy Chowdhury, Arthur Matthys, Michaela Junghänel, Thomas N. Gaitanos, Alja Podgornik, Thomas D. Black, Narasimha Reddy Vaka, Karl-Klaus Conzelmann, Nadine Gogolla
Aversive state processing in the posterior insular cortex
published pages: 1424-1437, ISSN: 1097-6256, DOI: 10.1038/s41593-019-0469-1
Nature Neuroscience 22/9 2019-09-26

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INSULARANXIETY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INSULARANXIETY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

MATCH (2020)

Discovering a novel allergen immunotherapy in house dust mite allergy tolerance research

Read More  

GelGeneCircuit (2020)

Cancer heterogeneity and therapy profiling using bioresponsive nanohydrogels for the delivery of multicolor logic genetic circuits.

Read More  

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More