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FeelAgain SIGNED

Restoring natural feelings from missing or damaged peripheral nervous system by model-driven neuroprosthesis

Total Cost €

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EC-Contrib. €

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Partnership

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 FeelAgain project word cloud

Explore the words cloud of the FeelAgain project. It provides you a very rough idea of what is the project "FeelAgain" about.

mechanical    subject    lack    patients    merge    diabetic    damage    interventional    conceptual    sensory    efficacy    movements    device    body    loop    fatigue    signals    periphery    ulcers    consequently    prone    examination    prosthesis    sensorized    clinical    sole    technological    transduction    counterbalancing    foot    perceive    surgical    rely    skin    peripheral    first    subjects    framework    neuroprosthesis    restoration    amputees    tools    translate    pain    optimize    natural    recorded    neuropathic    prosthetic    foreign    placement    types    neural    validated    relief    interfaces    feelagain    constructed    model    walking    protocols    due    stimulation    boosting    nerve    perceived    potentials    computational    brain    prevention    geometry    electrical    causes    fibers    associable    suffer    modeling    falls    sciatic    interface    amputation    functional    inputs    restoring    tests    amputee    deformations    ulcer    action    structures    embodiment    amputations    risk    placed    leg    feedback    avoidance    neuropathy    mimic    aberrant    functionalities    sensations   

Project "FeelAgain" data sheet

The following table provides information about the project.

Coordinator		 EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 1˙499˙637 €
 EC max contribution 1˙499˙637 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 1˙385˙032.00
2    INSTITUT MIHAJLO PUPIN RS (BEOGRAD) participant 114˙605.00

Map

 Project objective

Due to sensory loss diabetic patients are prone to falls and to foot ulcers, which consequently increase the risk of amputations. Because of the lack of sensory feedback amputees experience falls, perceive the prosthesis as a foreign body and therefore do not rely on it during walking. This causes counterbalancing movements that increase fatigue. Both types of patients suffer neuropathic pain, associable to aberrant sensory inputs. Neural pathways between the periphery and the brain are still functional above the damage or the amputation. Targeting these structures with peripheral neural interfaces could allow the restoration of natural sensory functionalities. The aim of project is to develop the first neuroprosthesis restoring natural foot sensations, through sciatic nerve stimulation, to patients with diabetic neuropathy or leg amputation. To that aim we will develop a detailed computational model of the sensory loop of the sciatic nerve. It will merge the electrical stimulation effects on sensory fibers and transduction of mechanical deformations of the skin into action potentials. Modelling results will be validated. Applying this modeling framework we will optimize the geometry of a peripheral neural interface, its surgical placement and define stimulation protocols that mimic natural sensory feedback responses. Effective device for feedback restoration will be constructed, able to translate the signals recorded by sensorized sole placed under the prosthetic or diabetic foot into the natural foot sensations perceived by subject. The interventional tools for embodiment boosting and pain relief will be developed. Clinical tests on amputee and diabetic subjects will assess the efficacy of the FeelAgain conceptual and technological framework by examination of pain, embodiment, ulcer prevention, falls avoidance and walking ability.

 Publications

year authors and title journal last update
List of publications.
2019 Francesco Maria Petrini, Marko Bumbasirevic, Giacomo Valle, Vladimir Ilic, Pavle Mijović, Paul Čvančara, Federica Barberi, Natalija Katic, Dario Bortolotti, David Andreu, Knut Lechler, Aleksandar Lesic, Sanja Mazic, Bogdan Mijović, David Guiraud, Thomas Stieglitz, Asgeir Alexandersson, Silvestro Micera, Stanisa Raspopovic
Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain
published pages: 1356-1363, ISSN: 1078-8956, DOI: 10.1038/s41591-019-0567-3 		Nature Medicine 25/9 2020-01-30
2019 Francesco Maria Petrini, Giacomo Valle, Marko Bumbasirevic, Federica Barberi, Dario Bortolotti, Paul Cvancara, Arthur Hiairrassary, Pavle Mijovic, Atli Örn Sverrisson, Alessandra Pedrocchi, Jean-Louis Divoux, Igor Popovic, Knut Lechler, Bogdan Mijovic, David Guiraud, Thomas Stieglitz, Asgeir Alexandersson, Silvestro Micera, Aleksandar Lesic, Stanisa Raspopovic
Enhancing functional abilities and cognitive integration of the lower limb prosthesis
published pages: eaav8939, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aav8939 		Science Translational Medicine 11/512 2020-01-30
2019 Francesco M. Petrini, Alberto Mazzoni, Jacopo Rigosa, Federica Giambattistelli, Giuseppe Granata, Beatrice Barra, Alessandra Pampaloni, Eugenio Guglielmelli, Loredana Zollo, Marco Capogrosso, Silvestro Micera, Stanisa Raspopovic
Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses
published pages: , ISSN: 1475-925X, DOI: 10.1186/s12938-019-0659-9 		BioMedical Engineering OnLine 18/1 2020-01-30

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The information about "FEELAGAIN" are provided by the European Opendata Portal: CORDIS opendata.

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