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ReSOLUTE SIGNED

Research empowerment on solute carriers (ReSOLUTE)

Total Cost €

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EC-Contrib. €

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Partnership

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 ReSOLUTE project word cloud

Explore the words cloud of the ReSOLUTE project. It provides you a very rough idea of what is the project "ReSOLUTE" about.

networks    cemm    omics    central    cell    et    vifor    worldwide    redundant    deorphanisation    parallel    carriers    generation    novartis    sme    grade    network    slc    medizinische    systematic    academic    suitability    gene    leiden    plan    interlinked    metabolomics    functional    landscape    pfizer    solute    ag    manner    lines    decisive    aventis    bayer    max    class    forschung    resolute    acceleration    merges    family    sanofi    recherche    cover    datasets    accessed    binders    goals    axxam    knowledgebase    seven    strategy    genetic    tractable    collection    coupling    prioritized    core    limited    time    ingelheim    intensity    veloppement    inducing    hardware    affinity    wien    six    data    certain    list    tools    members    super    spa    standards    uk    assay    eacute    industrial    institut    genomic    expertise    uuml    industry    repositories    antibodies    establishing    slcs    manchester    pharma    complementary    boehringer    variety    engineering    formats    planck    transform    elected    proteomics    validated    drug    group    connections    proteins    combining    systematically    empowerment    oxford    univ   

Project "ReSOLUTE" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://re-solute.eu/
 Total cost 23˙850˙000 €
 EC max contribution 12˙000˙000 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2016-10-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 6˙841˙011.00
2    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 1˙220˙266.00
3    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 1˙208˙850.00
4    AXXAM SPA IT (BRESSO MILANO) participant 1˙141˙250.00
5    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 723˙588.00
6    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 483˙750.00
7    UNIVERSITAT WIEN AT (WIEN) participant 379˙812.00
8    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 1˙470.00
9    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) participant 0.00
10    BOEHRINGER INGELHEIM INTERNATIONALGMBH DE (INGELHEIM) participant 0.00
11    NOVARTIS PHARMA AG CH (BASEL) participant 0.00
12    PFIZER LIMITED UK (SANDWICH) participant 0.00
13    SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT FR (Chilly Mazarin) participant 0.00
14    VIFOR (INTERNATIONAL) AG CH (ST GALLEN) participant 0.00

Map

 Project objective

The Research empowerment on solute carriers (ReSOLUTE) proposal aims at inducing a decisive acceleration in the intensity of SLC research worldwide while establishing solute carriers (SLCs) as a tractable target class. It is composed of a core consortium of seven academic/SME members (CeMM, Univ. of Oxford, Univ. of Manchester, AXXAM Spa, Univ. Leiden, Max-Planck Institut für medizinische Forschung, Univ. Wien) and six industrial partners (Pfizer Limited UK, Novartis Pharma AG, Boehringer-Ingelheim, Vifor Pharma Group, Sanofi Aventis Recherche et Développement, Bayer AG) with established and complementary expertise combining industry grade standards and systems level principle-driven analysis.

ReSOLUTE merges systematic and focused approaches: 1) the generation of reliable and validated ‘hardware’ such as cell lines, proteins, antibodies/high affinity binders and large ‘omics’ datasets, 2) a central deorphanisation process coupling genomic engineering to metabolomics and supported by genetic and proteomics studies, 3) a non-redundant process to test systematically the suitability of a certain SLC to a variety of assay formats, 4) a collection of interlinked networks that cover different expertise, datasets and functional connections among SLCs, integrated into large-scale data repositories and a dedicated knowledgebase. The ReSOLUTE strategy will be applied in parallel at the super-family level and, in a more in-depth manner, to a prioritized gene list elected to be potential drug targets. To implement this and achieve the expected goals, the consortium is supported by a large network of academic and industrial partners with specific knowledge of certain SLCs and tools, willing to be accessed at any time and provide specific expertise. Together with a strong dissemination and exploitation plan, we therefore expect that ReSOLUTE will transform the landscape of SLC research for years to come.

 Deliverables

List of deliverables.
ReSOLUTE knowledgebase Documents, reports 2020-04-14 17:13:23
ReSOLUTE database Websites, patent fillings, videos etc. 2020-04-14 17:13:23
Data Management Plan 1 Documents, reports 2020-04-14 17:13:23
Data Mining Documents, reports 2020-04-14 17:13:23
Vector generation Documents, reports 2020-04-14 17:13:23

Take a look to the deliverables list in detail:  detailed list of ReSOLUTE deliverables.

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The information about "RESOLUTE" are provided by the European Opendata Portal: CORDIS opendata.

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