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SM-Epigen SIGNED

Revealing the Epigenetic Regulatory Network with Single-Molecule Precision

Total Cost €

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EC-Contrib. €

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Partnership

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 SM-Epigen project word cloud

Explore the words cloud of the SM-Epigen project. It provides you a very rough idea of what is the project "SM-Epigen" about.

circulating    act    tools    structures    single    histones    blood    free    marks    cells    strategies    light    bridging    network    devise    histone    origin    form    fundamental    regulation    remodelers    directions    interactions    epigenetic    impeding    successful    chromatin    stem    locations    cell    diagnostic    therapeutic    yield    interact    technological    tissue    ascertained    shed    regulatory    nucleosome    fuelled    language    octamer    detection    direct    modifications    pave    modules    unravel    proof    powerful    throughput    diseases    genes    proteomics    harness    packaged    regulate    multiple    genome    nucleosomes    dna    cancer    mapping    methylation    core    genomic    reveal    transformative    questions    human    functional    molecule    differentiated    basic    speculation    transcription    lacks    hypothesis    interface    combinatorial    tf    genomics    combinations    gap    holds    solution    combinatorially    tfs    outcomes    technologies   

Project "SM-Epigen" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

Map

 Project objective

Genes and genomic elements are packaged by chromatin structures that regulate their activity. The fundamental unit of chromatin is the nucleosome, composed of an octamer of histones. The large numbers of histone modifications, chromatin remodelers and transcription factors (TFs) that interact with our genome has fuelled speculation that multiple elements act combinatorially to direct specific outcomes. However, the field lacks technologies for detection and analysis of such combinations, thus impeding our ability to test this hypothesis and shed light on human genome regulation. Our recent proof-of-principle for a single-molecule system for mapping combinatorial chromatin modifications holds the technological solution. This powerful method can identify directly unique combinations of epigenetic marks and reveal regulatory modules that can only be ascertained by single-molecule studies. The proposed project will scale-up and advance our technology to establish robust high-throughput systems for investigating combinatorial chromatin and TF interactions and identify their genomic locations, thus bridging the gap between single-molecule proteomics and genomics. We will apply it to address basic questions in epigenetic regulation during early development, and define the network of interactions between histone marks, DNA methylation and the core TFs in stem cells and differentiated cells. We will also harness our technology to reveal the tissue-of-origin of cell-free DNA circulating in our blood in the form of nucleosomes, and apply it to devise novel strategies for early detection of cancer and other diseases. Successful implementation and dissemination of these novel systems will yield a transformative new technology for functional genomics that will unravel the chromatin language during early development. This work will open new research directions at the interface of genomics and proteomics, and pave the way for the development of therapeutic and diagnostic tools.

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The information about "SM-EPIGEN" are provided by the European Opendata Portal: CORDIS opendata.

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