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Homo.symbiosus SIGNED

Assessing, preserving and restoring man-microbes symbiosis

Total Cost €

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EC-Contrib. €

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Partnership

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 Homo.symbiosus project word cloud

Explore the words cloud of the Homo.symbiosus project. It provides you a very rough idea of what is the project "Homo.symbiosus" about.

era    microbes    recognition    concomitantly    co    tipping    altered    societies    transitions    considering    man    grounds    insights    dysbiotic    tentatively    birth    applies    population    organ    reinforce    points    strategies    clinical    individualized    incidence    diseases    counter    signals    care    circles    gut    ing    environmental    human    nutritional    balanced    prone    therapeutics    quantitative    species    validate    therapeutic    revolution    personalized    alleviation    symbiosis    predictors    favoured    trials    ecology    symptoms    alternative    break    ecological    critical    earth    preventive    alone    nutrition    experimental    mediated    fraction    preclinical    geared    attitudes    entered    restore    dysbiosis    shift    transition    microbiome    assemble    crosstalk    carry    modern    disease    immune    health    vicious    challenged    paradigm    host    holobiont    interactions    threat    cohort    context    microbiomics    contributions    robustness    theoretical    stable    aggravating    diet    acting    modalities    derive    triggers    lifestyles    latter    evolution    auto    model    true    incurable    functional   

Project "Homo.symbiosus" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙491˙014 €
 EC max contribution 2˙491˙014 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 2˙491˙014.00

Map

 Project objective

The microbiomics revolution has favoured the recognition of the gut as a true organ and the importance of man-microbes symbiosis in health and disease. Derived from a long co-evolution the latter has been challenged by numerous environmental triggers, modern lifestyles, changes in birth modalities, nutritional transition and therapeutic attitudes. A large fraction of the human population has tentatively entered a man-microbes dysbiotic state characterized by altered interactions between microbiome and host features with auto-aggravating crosstalk signals. The result is increased incidence of incurable immune-mediated diseases of modern societies that affect a third the human population on earth today and for which current therapeutics only address symptoms alleviation, rather than considering man as a holobiont. In this context and its resulting threat for the human species, I will carry out a project geared to open a new era of individualized preventive care and novel gut ecology-based therapeutic approaches. The project will assemble insights and contributions from theoretical to experimental ecology, quantitative and functional microbiomics, preclinical work, cohort studies and clinical trials, so as to: • Validate the concept of critical transition and alternative stable state as it applies to a shift from man-microbes symbiosis to disease-prone man-microbes dysbiosis • Assess the potential of diet alone to promote such a shift • Model the symbiosis-to-dysbiosis transitions and derive predictors of tipping points • Propose counter-measures that may allow to break vicious circles and restore a balanced, health-prone, man-microbes symbiosis by concomitantly acting upon microbiome and host features • Validate strategies to reinforce ecological robustness and restore man-microbes symbiosis Based on a paradigm shift, the proposed work will set the grounds for future personalized preventive nutrition and clinical management considering man as a true holobiont.

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The information about "HOMO.SYMBIOSUS" are provided by the European Opendata Portal: CORDIS opendata.

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