#	Pagina
attuale pagina	/open-h2020/projects/221394/index.html

Opendata, web and dolomites

CRC-MTOs SIGNED

Colorectal Cancer Mouse Tumor Organoids as Pre-clinical Models for Therapeutical Testing

Total Cost €

EC-Contrib. €

Partnership

Views

CRC-MTOs project word cloud

Explore the words cloud of the CRC-MTOs project. It provides you a very rough idea of what is the project "CRC-MTOs" about.

al background lack nature operate companies p53 arising public treat translational newly grants collaborations strategic biobank genes tgf genome disease genetic cancer progress invaluable crcs exploited despite models clinical first demonstrated tumor final licenced organoids freedom driver largely collection beta mto egfr extends aid progression spread wnt hampered pharmaceutical mouse patients tauriello immunotherapies cover tool bearing efficient tumors immunocompetent metastatic complete signaling mtos limitations 2018 prevented causes drugs compound subtypes crc stage create private tools death transfer colorectal preclinical model ready academic recreates mice generation editing therapies alterations et basic

Project "CRC-MTOs" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) Organization address address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA city: BARCELONA postcode: 8028 website: www.irbbarcelona.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	149˙955 €
EC max contribution	149˙955 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-12-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) Organization address address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA city: BARCELONA postcode: 8028 website: www.irbbarcelona.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	149˙955.00

Map

Project objective

Colorectal cancer (CRC) is one of the leading causes of death by cancer, which is largely associated to metastatic spread of the disease. Progress to develop efficient therapies, including immunotherapies, for patients with metastatic CRC has been hampered by the lack of preclinical models to study late stage CRC in an immunocompetent background. We have developed the first genetic mouse model of advanced CRC in immunocompetent mice. This model is based in a biobank of mouse tumor organoids (MTOs) derived from tumors arising in compound mice bearing genetic alterations in 4 driver genes associated to CRC progression: WNT, EGFR, p53, and TGF-beta signaling. We have demonstrated that these MTOs represent an invaluable tool for basic and pre-clinical research in CRC, in particular to test immunotherapies (Tauriello et al., Nature 2018).

Despite its potential, the MTO biobank has limitations for translational research. They were generated as academic tools which has prevented their use in technology transfer projects and collaborations with pharmaceutical companies. In addition, they do not cover all the different CRC subtypes. We propose to create an improved and more complete second-generation MTO biobank that a) recreates the described pre-clinical model of advanced CRC, b) extends the model collection to other subsets of CRCs by means of genome editing tools and c) grants freedom to operate. These newly generated MTOs will represent unique tools ready to be licenced and exploited in strategic public-private collaborations with the final goal to aid in the development of new drugs to treat advanced CRC patients.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CRC-MTOS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CRC-MTOS" are provided by the European Opendata Portal: CORDIS opendata.