Explore the words cloud of the RACING project. It provides you a very rough idea of what is the project "RACING" about.
The following table provides information about the project.
Coordinator |
UNIVERSITY OF BRISTOL
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Total cost | 224˙933 € |
EC max contribution | 224˙933 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2018 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2019 |
Duration (year-month-day) | from 2019-04-01 to 2021-03-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | UNIVERSITY OF BRISTOL | UK (BRISTOL) | coordinator | 224˙933.00 |
Cyclobutanes are common motifs in natural products and are increasingly important in medicinal chemistry since they can orient substituents along precise vectors. However, methods to construct cyclobutanes are less developed in comparison to their smaller and larger rings. Consequently, novel methods to access functionalized cyclobutanes are highly desirable and would be of considerable value for the discovery of new bioactive compounds. In the last decade, the host group and others have contributed significantly to the development of boron 1,2-migration chemistry which has found numerous applications in organic synthesis. Normally, 1,2-metallate shifts in boronate complexes are induced by α-leaving groups or by reactions of alkenyl boronates with halogens, π-acidic metals, or radicals. Herein, we are proposing a fundamentally new strategy to induce 1,2-metallate rearrangement, via a ring expansion of vinyl cyclopropyl boronate complex activated by an electrophile or by photoredox or transition metal catalysis. This novel process would lead to highly versatile boronic ester containing cyclobutanes, which can be transformed into other valuable functional groups. Furthermore, we plan to use chiral ligands in combination with palladium catalysis in this novel process, leading to enantioenriched chiral cyclobutyl boronic esters. These novel methodologies not only benefit from the formation of highly functionalized cyclobutanes, but also lay solid foundations for the development of other ring-expansion induced 1,2-metallate rearrangements. The scope of these processes will be carefully investigated, and mechanistic studies of the photoreaction will be carried out using advanced physical/chemical methods. Finally, this project will enable significant knowledge transfer between the host and researcher, while forging new academic networks within the scientific community.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RACING" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "RACING" are provided by the European Opendata Portal: CORDIS opendata.
Ultra-high field imaging of perceptual learning and human brain plasticity
Read MoreNeural mechanisms of crossmodal activity in blind and sighted individuals
Read MoreQuantitative insight into chromatin nanoscale structure: sub-nuclear organisation of oncoprotein DEK
Read More