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RACING SIGNED

Rapid access to functionalized cyclobutanes via ring expansion strategies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RACING project word cloud

Explore the words cloud of the RACING project. It provides you a very rough idea of what is the project "RACING" about.

benefit    metallate    group    decade    migration    palladium    versatile    mechanistic    vinyl    transfer    natural    host    foundations    photoredox    cyclopropyl    lay    networks    synthesis    enantioenriched    boronic    alpha    last    proposing    combination    transformed    chemical    community    pi    chiral    construct    organic    ring    precise    motifs    forging    medicinal    esters    leaving    normally    academic    compounds    herein    substituents    radicals    cyclobutyl    considerable    orient    valuable    electrophile    halogens    plan    boronates    chemistry    desirable    physical    metal    ester    groups    transition    catalysis    researcher    containing    bioactive    fundamentally    strategy    solid    activated    scientific    cyclobutanes    photoreaction    significantly    boron    contributed    alkenyl    smaller    scope    complexes    shifts    metals    ligands    rings    functional    functionalized    rearrangement    reactions    boronate    found    rearrangements    expansion    larger    vectors    discovery    carefully    induce    acidic    consequently   

Project "RACING" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 224˙933.00

Map

 Project objective

Cyclobutanes are common motifs in natural products and are increasingly important in medicinal chemistry since they can orient substituents along precise vectors. However, methods to construct cyclobutanes are less developed in comparison to their smaller and larger rings. Consequently, novel methods to access functionalized cyclobutanes are highly desirable and would be of considerable value for the discovery of new bioactive compounds. In the last decade, the host group and others have contributed significantly to the development of boron 1,2-migration chemistry which has found numerous applications in organic synthesis. Normally, 1,2-metallate shifts in boronate complexes are induced by α-leaving groups or by reactions of alkenyl boronates with halogens, π-acidic metals, or radicals. Herein, we are proposing a fundamentally new strategy to induce 1,2-metallate rearrangement, via a ring expansion of vinyl cyclopropyl boronate complex activated by an electrophile or by photoredox or transition metal catalysis. This novel process would lead to highly versatile boronic ester containing cyclobutanes, which can be transformed into other valuable functional groups. Furthermore, we plan to use chiral ligands in combination with palladium catalysis in this novel process, leading to enantioenriched chiral cyclobutyl boronic esters. These novel methodologies not only benefit from the formation of highly functionalized cyclobutanes, but also lay solid foundations for the development of other ring-expansion induced 1,2-metallate rearrangements. The scope of these processes will be carefully investigated, and mechanistic studies of the photoreaction will be carried out using advanced physical/chemical methods. Finally, this project will enable significant knowledge transfer between the host and researcher, while forging new academic networks within the scientific community.

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