Opendata, web and dolomites

SYNBIO.ECM SIGNED

SYNBIO.ECM: Designer extracellular matrices to program healthy and diseased cardiac morphogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SYNBIO.ECM project word cloud

Explore the words cloud of the SYNBIO.ECM project. It provides you a very rough idea of what is the project "SYNBIO.ECM" about.

differential    successful    found    modest    interactions    quantitative    maturation    engineers    tremendous    cells    resolution    dna    extracellular    trabeculation    individual    engineering    despite    model    models    microscopy    leverage    sequencing    cardiac    experimental    process    matrix    worldwide    medical    assemblies    solution    manufacturing    hoc    situ    designer    synbio    tissues    inputs    class    asked    aided    pluripotent    successes    platform    predictable    multiscale    largely    parts    libraries    tools    force    phases    dr    2005    computationally    ignored    cell    endy    traction    cad    bioprint    move    biotechnology    programmable    heart    unreliable    subcellular    biology    clinical    nature    functions    transformed    super    progressively    equations    emerged    meet    tissue    ecm    ordinary    synthetic    stem    effect    framework    letter    behavior    computational    compaction    biological    ad    expensive    fluorescence    computer    recapitulate    genetic    progress    human   

Project "SYNBIO.ECM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PAVIA 

Organization address
address: STRADA NUOVA 65
city: PAVIA
postcode: 27100
website: www.unipv.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙999˙375 €
 EC max contribution 1˙999˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) coordinator 1˙999˙375.00

Map

 Project objective

To meet medical needs worldwide, tissue engineering must move from successful pre/clinical products towards an effective process to meet Worldwide medical needs, but this is challenging since a quantitative design framework has not emerged, yet. Synthetic biology (SYNBIO) was the solution that genetic engineers found to the same problem: “Despite tremendous individual successes in genetic engineering and biotechnology […], why is the engineering of useful synthetic biological systems still an expensive, unreliable and ad hoc research process?” asked Dr. Endy in a 2005 letter to Nature. The SYNBIO solution included: i) libraries of DNA parts with well-characterized effect on cells; ii) tools to computationally design system-level assemblies, or designer-DNA; and, iii) bottom-up engineering of cell functions using progressively more complex designer-DNA. Effectively, SYNBIO introduced a computer-aided design and manufacturing (CAD/M) platform that transformed the process of engineering cells. However, since inputs from the extracellular matrix (ECM) have largely been ignored, progress towards programmable tissue-level behavior have been more modest.

Here, we will build on my experience with computational and experimental models in cardiac tissue engineering to develop a CAD/M framework for engineering cardiac tissues with computationally predictable properties, or designer-ECM. To characterize ECM-cell interactions, we will use traction force and super-resolution microscopy with fluorescence in-situ sequencing. To model multiscale ECM-cell interactions, we will use ordinary differential equations and subcellular element models. Finally, we will leverage ECM parts and human induced pluripotent stem cells to bioprint designer-ECM that recapitulate three phases of heart development: trabeculation, compaction, and maturation.

With synthetic matrix biology (SYNBIO.ECM), we will develop a CAD/M-based process and a new class of products for cardiac tissue engineering.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYNBIO.ECM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SYNBIO.ECM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

BECAME (2020)

Bimetallic Catalysis for Diverse Methane Functionalization

Read More  

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

GelGeneCircuit (2020)

Cancer heterogeneity and therapy profiling using bioresponsive nanohydrogels for the delivery of multicolor logic genetic circuits.

Read More