Opendata, web and dolomites

FuelVesicles SIGNED

Commercialization of open vesicles to fuel downstream reaction networks

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FuelVesicles project word cloud

Explore the words cloud of the FuelVesicles project. It provides you a very rough idea of what is the project "FuelVesicles" about.

constant    minimal    living    cytosol    molecules    periods    interaction    demanding    exist    ratio    stops    mobile    reaction    energy    draining    diphosphate    adenosine    biotech    antibiotics    hasn    construct    ip    external    creates    tried    houses    carry    vesicles    synthetic    power    biotechnological    lasting    kept    cascade    feeding    bio    acids    partnering    drug    chemical    endergonic    reactions    mimic    chemistry    plan    longer    strengthen    feasibility    reported    reserves    vitamins    sustainable    networks    fuel    cell    poc    triphosphate    mitochondria    truly    commercialization    cells    numerous    operate    evident    dna    managed    time    autonomous    drive    autonomously    analytics    nucleic    acid    gain    operation    prepare    atp    materials    depletion    life    supply    proteins    magnitude    generation    dissipation    limited    free    actions    adp    away    removal    functional    syntheses    form    amino    tests    scientists    completely    sequencing    intervention    equilibrium    bottleneck   

Project "FuelVesicles" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 150˙000.00

Map

 Project objective

Numerous biotechnological processes require Adenosine-5'-triphosphate (ATP) as a form of free energy to drive endergonic reactions. The bottleneck is that after some time the reaction stops due to adenosine diphosphate (ADP) build up and the depletion of energy reserves. In living cells, functional and sustainable out-of-equilibrium networks exist. Scientists have tried to mimic such autonomous systems without the need for external interaction, or fuel supply. Real success hasn’t been reported. We managed to construct a fuel system in synthetic vesicles that is kept away from equilibrium by controlling the energy dissipation. These vesicles are power houses for sustainable production of ATP (and removal of ADP) much like mitochondria power the ATP-demanding reactions in the cytosol of a cell. In further tests, we were able to reach an order of magnitude longer autonomous operation of a real-life application making our approach truly unique. All the comparable approaches focus on feeding the reaction with ATP without draining of the ADP. Our system creates the fuel from an amino acid while the ATP/ADP ratio is kept constant. The gain for applications is evident; the reactions, and therefore systems, can operate autonomously for long periods of time. This is particularly important for mobile systems with limited supply of reaction materials and where user intervention has to be minimal. Therefore, we expect to enable a completely new generation of autonomous biotech and chemistry applications, such as targeted drug delivery, analytics of nucleic acids or proteins, and cascade reactions for (bio)chemical syntheses of antibiotics, vitamins and other complex molecules. In this PoC, we will advance the commercialization of our approach by carrying out a technical feasibility for sustainable production of ATP for long-lasting sequencing of DNA application. In addition, we will prepare a commercialization plan, carry out partnering actions and strengthen the IP further.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FUELVESICLES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FUELVESICLES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More  

SLAMseq (2019)

SLAMseq: Temporal resolution in gene expression profiling across multiple platforms

Read More  

NEUTRAMENTH (2018)

A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol

Read More