HEM_ID

HEMatopoietic cell IDentity : genetic and epigenetic regulation in normal and malignant hematopoiesis

Coordinatore	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA    more  Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: IT-20126 contact info Titolo: Dr. Nome: Anastasia Cognome: Sguera Email: send email Telefono: 390264000000 Fax: +39 02 64483569
Nazionalità Coordinatore	Italy [IT]
Totale costo	3˙269˙702 €
EC contributo	3˙269˙702 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-ITN
Funding Scheme	MC-ITN
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-11-01   -   2015-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA  Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: IT-20126 contact info Titolo: Dr. Nome: Anastasia Cognome: Sguera Email: send email Telefono: 390264000000 Fax: +39 02 64483569	IT (MILANO)	coordinator	438˙385.00
2	Source Bioscience plc  Organization address address: "ORCHARD PLACE, BUSINESS PARK 1" city: NOTTINGHAM postcode: NG8 6PX contact info Titolo: Mr. Nome: Robert Cognome: Bakewell Email: send email Telefono: 441160000000 Fax: 441160000000	UK (NOTTINGHAM)	participant	271˙759.00
3	INSTITUT CURIE  Organization address address: 26, rue d'Ulm city: PARIS postcode: 75248 contact info Titolo: Ms. Nome: Corinne Cognome: Cumin Email: send email Telefono: 33156246620 Fax: 33156246627	FR (PARIS)	participant	270˙184.00
4	CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE  Organization address address: Rue Laurent Fries 1 city: ILLKIRCH GRAFFENSTADEN postcode: 67404 contact info Titolo: Dr. Nome: Brooks Cognome: Steve Email: send email Telefono: 33388653394 Fax: 33388653203	FR (ILLKIRCH GRAFFENSTADEN)	participant	269˙493.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Sandrine Cognome: Magnetto Email: send email Telefono: 330472000000 Fax: 330479000000	FR (PARIS)	participant	264˙653.00
6	UNIVERSITE JOSEPH FOURIER GRENOBLE 1  Organization address address: "Avenue Centrale, Domaine Universitaire 621" city: GRENOBLE postcode: 38041 contact info Titolo: Ms. Nome: Sophie Cognome: Beaubron Email: send email Telefono: 33476514488 Fax: 33476635956	FR (GRENOBLE)	participant	264˙653.00
7	NERVIANO MEDICAL SCIENCES S.R.L  Organization address address: VIALE LUIGI PASTEUR 10 city: NERVIANO postcode: 20014 contact info Titolo: Dr. Nome: Fabio Cognome: Gasparri Email: send email Telefono: +39 0331 581706 Fax: +39 0331 581233	IT (NERVIANO)	participant	261˙285.00
8	ACADEMISCH ZIEKENHUIS GRONINGEN  Organization address address: Hanzeplein 1 city: GRONINGEN postcode: 9713 GZ contact info Titolo: Prof. Nome: Gerald Cognome: De Haan Email: send email Telefono: +3150363 2722 Fax: +315063 2913	NL (GRONINGEN)	participant	259˙231.00
9	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA  Organization address address: Piazzale Aldo Moro 5 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Alessandro Cognome: Fatica Email: send email Telefono: 390650000000 Fax: 390650000000	IT (ROMA)	participant	256˙445.00
10	CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH  Organization address address: Dr. Ignaz Seipel-Platz 2 city: WIEN postcode: 1010 contact info Titolo: Prof. Nome: Giulio Cognome: Superti-Furga Email: send email Telefono: 4314020000000 Fax: 4314020000000	AT (WIEN)	participant	255˙444.00
11	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Eusebio Cognome: Jimènez Arroyo Email: send email Telefono: 34915668852 Fax: 34915668913	ES (MADRID)	participant	238˙763.00
12	BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING  Organization address address: Al. Fleming Street 34 city: VARI-ATHENS postcode: 16672 contact info Titolo: Dr. Nome: Charalambos Cognome: Savakis Email: send email Telefono: +30 210 8976404 Fax: +30 210 9653934	EL (VARI-ATHENS)	participant	219˙407.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been well defined in the last years, the precise molecular circuits governing the balance between proliferation/commitment/specification and how these are corrupted in disease are largely unknown. The focus of Hem-ID is a highly integrated approach to study the functional interactions between the genetic regulatory circuits orchestrated by transcription factors –TFs-, (that direct the progressive cell type specification) and epigenetic mechanisms (that establish the “cellular memory” that fixes cell fate decisions during differentiation) in physiological hematopoiesis and in leukemia with the final goal of formulating novel diagnostic/prognostic markers and therapeutic approaches in treating leukemias. HEM_ID will: -Decipher Modular Networks assembled by master TFs controlling hematopoietic self renewal and differentiation and the molecular dynamics of TFs/DNA interactions by unique biophysical approache -Identify epigenetic modifiers (new relevant loci, -epiQTLs, DNAmethylation, Polycomb dependent-gene silencing, miRNA and long non coding RNAs) involved in the pathogenesis of leukemias. The strength of Hem-ID ITN lies in the high quality multidisciplinary -but strictly integrated- expertise and technological platforms covering the complete pathway from basic research to its clinical exploitation- contributed from both public Institutions and Private sector and made available to Hem-ID Fellows. Besides research, an integrated training program of scientific and complementary activities will be offered to HEM-ID Fellows that will complement and strengthen their career development.'

Introduzione (Teaser)

Similar to fingerprints, each blood cell type has a unique molecular identity. A European consortium has joined forces to discover the identity of different haematopoietic cells and translate their findings into clinical practice.