DSBRECA

Relevance of double strand break repair pathway choice in human disease and cancer

 Coordinatore UNIVERSIDAD DE SEVILLA 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Spain [ES]
 Totale costo 1˙416˙866 €
 EC contributo 1˙416˙866 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2011-StG_20101109
 Funding Scheme ERC-SG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-01-01   -   2016-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SEVILLA

 Organization address address: CALLE S. FERNANDO 4
city: SEVILLA
postcode: 41004

contact info
Titolo: Dr.
Nome: Pablo
Cognome: Huertas Sanchez
Email: send email
Telefono: +34 954467667
Fax: +34 954461664

ES (SEVILLA) hostInstitution 1˙416˙866.00
2    UNIVERSIDAD DE SEVILLA

 Organization address address: CALLE S. FERNANDO 4
city: SEVILLA
postcode: 41004

contact info
Titolo: Ms.
Nome: Margarita
Cognome: Martinez-Pais Loscertales
Email: send email
Telefono: +34 954488129
Fax: +34 954488127

ES (SEVILLA) hostInstitution 1˙416˙866.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

pathway    abnormalities    pathways    choice    repair    homologous    cancer    syndromes    double    inherited    treatment    genetically    mechanisms    extremely    dsbs    leads   

 Obiettivo del progetto (Objective)

'Double strand breaks (DSBs) repair is essential for normal development. While the complete inability to repair DSBs leads to embryonic lethality and cell death, mutations that hamper this repair cause genetically inherited syndromes, with or without cancer predisposition. The phenotypes associated with these syndromes are extremely varied, and can include growth and mental retardation, ataxia, skeletal abnormalities, immunodeficiency, premature aging, etc. Moreover, DSBs play an extremely relevant role in the biology of cancer. Alterations in the DSBs repair pathways facilitate tumour progression and are selected early on during cancer development. On the other hand, DSBs are the molecular base of radiotherapies and chemotherapies. This double role of DSBs in both, the genesis and treatment of cancer makes the understanding of the mechanisms that control their repair of capital importance in cancer research. DSBs are repaired by two major mechanisms that compete for the same substrate. Both ends of the DSB can be simple re-joined with little or no processing, a mechanism known as non-homologous end-joining. On the other hand, DSBs can be processed and engaged in a more complex repair pathway called homologous recombination. This pathway uses the information present in a homologue sequence. The balance between these two pathways is exquisitely controlled and its alteration leads to the appearance of chromosomal abnormalities and contribute to the diseases aforementioned. However, and despite its importance, the network controlling the choice between both is poorly understood. Here, we propose a series of research lines designed to investigate how the choice between both DSBs repair pathways is made, its relevance for cellular and organismal survival and disease, and its potential as a therapeutic target for the treatment of cancer and some genetically inherited disorders.'

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