ACAD

Asymmetric Chlorofunctionalization of Activated carbon-carbon Double bonds

Coordinatore	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH    more  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Prof. Nome: Erick Cognome: Carreira Email: send email Telefono: +41 44 632 28 30 Fax: +41 44 632 13 28
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	221˙173 €
EC contributo	221˙173 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IOF
Funding Scheme	MC-IOF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-04-01   -   2014-10-15

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Prof. Nome: Erick Cognome: Carreira Email: send email Telefono: +41 44 632 28 30 Fax: +41 44 632 13 28	CH (ZUERICH)	coordinator	221˙173.05

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 Obiettivo del progetto (Objective)

'In collaboration with Prof. S. E. Denmark and Prof. E. M. Carreira the researcher will work with two of the world’s leaders in organic chemistry in the complementary areas of methodology development and natural product synthesis, respectively. In the outgoing phase a novel, asymmetric, Lewis base activated, Lewis acid catalysed reaction will be developed to allow for the asymmetric chlorofuntionalization of activated carbon-carbon double bonds. This objective will be achieved through the thorough screening of reaction profile with respect to Lewis acid, Lewis base, electrophile and trapping agent and through the analysis of reaction kinetics using techniques such as ReactIR and rapid-injection NMR spectroscopy. The Denmark group’s experience in this area, built up over the last 15 years, will allow for efficient iteration and optimisation of the protocol. In the return phase application of the developed methodology towards the synthesis of the chlorosulfolipid family of natural products is planned, along with the transferring of the obtained knowledge/skills to European researchers. Specifically, this will be achieved through the mentoring of junior students. The proposed research and research plan is specifically designed to test and develop the researchers leadership qualities and ability for independent study as well as to provide experience and knowledge in an area of increasing importance. The ultimate ambition of the researcher is to obtain and sustain a successful, independent academic position in a European institution. With this in mind the proposed research represents an excellent career development opportunity. This proposal will initially raise the profile of European research and, through the training of the next generation of European researchers during the return phase, increase the competitiveness of European science.'

Introduzione (Teaser)

Nature is a treasure trove of interesting molecules that inspire new products and processes. EU-funded scientists made important progress towards selectively synthesising complex natural molecules that are gaining increasing attention.