IMMUNE ENERGY

Extracellular adenosine role in energetic metabolism during immune response

Coordinatore	JIHOCESKA UNIVERZITA V CESKYCH BUDEJOVICICH    more  Organization address address: BRANISOVSKA 31A city: CESKE BUDEJOVICE postcode: 37005 contact info Titolo: Mr. Nome: Ji?í Cognome: Fajtl Email: send email Telefono: 420388000000
Nazionalità Coordinatore	Czech Republic [CZ]
Totale costo	283˙229 €
EC contributo	283˙229 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IOF
Funding Scheme	MC-IOF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-09-27   -   2015-03-26

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	JIHOCESKA UNIVERZITA V CESKYCH BUDEJOVICICH  Organization address address: BRANISOVSKA 31A city: CESKE BUDEJOVICE postcode: 37005 contact info Titolo: Mr. Nome: Ji?í Cognome: Fajtl Email: send email Telefono: 420388000000	CZ (CESKE BUDEJOVICE)	coordinator	283˙229.75

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 Obiettivo del progetto (Objective)

Immune response is energetically demanding process and although an improper regulation of energetic metabolism during immune challenges leads to various complications in human patients it is largely unknown how is the energetic metabolism regulated during the immune response. Extracellular adenosine is a strong candidate for this type of regulation; nevertheless it has never been studied for such role. Our work using Drosophila as a model strongly supports the view of adenosine being the signal connecting energy reallocation with immune response. The regulation of extracellular-adenosine levels and its signaling are now well defined in flies and the model allows various manipulations with the adenosine system in vivo. Therefore the model is now perfectly suitable for a systematic analysis of the adenosine regulation of energetic metabolism during various infections which should lead to a better understanding of the energetic costs of mounting an immune response. Results of such analysis could greatly contribute to our knowledge of host-pathogen interactions and some highly important biomedical problems. Goal of this project is for the applicant to learn the complex methodology of Drosophila infections and use these obtained skills for the systematic analysis of the adenosine role during immune response.