NADETOX

NAnomics in vitro DEvelopmental TOXcology

Coordinatore	TECHNISCHE UNIVERSITEIT DELFT    more  Organization address address: Stevinweg 1 city: DELFT postcode: 2628 CN contact info Titolo: Mrs. Nome: Karin Cognome: Graaf Van Der Email: send email Telefono: +31 15 2781773
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	183˙805 €
EC contributo	183˙805 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-19   -   2014-10-18

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT DELFT  Organization address address: Stevinweg 1 city: DELFT postcode: 2628 CN contact info Titolo: Mrs. Nome: Karin Cognome: Graaf Van Der Email: send email Telefono: +31 15 2781773	NL (DELFT)	coordinator	183˙805.80

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 Obiettivo del progetto (Objective)

'The progress made in improving the development and the production of nanoparticles (NPs) is enormous. Metallic nanoparticles (mNPs) are among the most widely used types of NPs in electronics, foods, containers, pharmaceutical drugs, cosmetics and paints. This trend will lead to an ever-increasing presence of NPs in the environment. This scenario means that humans and the environment will be exposed to more and more nanotechnology-based products whose health risks and environmental impacts of NPs might outweigh their benefits. In order to promote prevention and safety in manufacturing and handling of NPs, NADETOX aims at evaluating the nanodevelopmental toxicity of selected metallic cobalt, silver and gold NPs extensively used in nanomedicine for cancer therapy. This novel and multidisciplinary research project is based on the 3Rs in vitro approach (Reduction, Refinement, Replacement), involving the development of a mechanistically-based alternative method, Frog Embryo Teratogenesis Assay-Xenopus (FETAX), and the combined use of peculiar advanced spectrochemical, radioanalytical, biochemical and molecular biology techniques. These methods offer the opportunity to label NPs, avoiding surface modification, to localise and quantify them in organisms. NADETOX aims at the following goals: (i) characterisation of NPs establishing their size and morphology, (ii) study of stability and of the eventual release of metal ions from radiolabelled NPs in the reconstituted water medium suitable for the culture of Xenopus embryos (FETAX medium), (iii) evaluation of embryolethality and teratogenicity of NPs by FETAX assay, (iv) biokinetics studies to measure uptake, metabolic fate and biopersistence of NPs in Xenopus at embryo and larva stages and structure diagnosis at DNA level, to get information on the genomic stability following formation of DNA-adducts.'