BIOCHEMICAL IMAGING

Fatty acid processing and metabolism in muscle cells revealed by non-linear vibrational imaging

Coordinatore	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.    more  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Mr. Nome: Udo Cognome: Schreiner Email: send email Telefono: +49 6131 379 423 Fax: +49 6131 379 155
Nazionalità Coordinatore	Germany [DE]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-08-01   -   2016-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Mr. Nome: Udo Cognome: Schreiner Email: send email Telefono: +49 6131 379 423 Fax: +49 6131 379 155	DE (MUENCHEN)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Fatty acid (FA) intake and its subsequent fate are implicated the two most prevalent diseases in the developed world, coronary heart disease and type 2 insulin-resistant diabetes. More than 300 million people world-wide live with type 2 diabetes, and its incidence is increasing rapidly, especially in developing countries. In Europe alone, direct medical expenses for type 2 diabetes totals more than 30 Billion € per year and more than 50% of these costs are related to hospitalization. This Career Integration Grant application outlines the PI’s research programme to use a non-linear vibrational imaging technique in order to explore the underlying FA dynamics during ectopic fat deposition and FA metabolism in muscle cells.

Ectopic fat appears in muscle of insulin-resistant, type 2 diabetics and also, paradoxically, in endurance trained athletes – who have acute insulin sensitivity. The methods developed in this proposal will provide a platform for answering many unresolved questions regarding FA dynamics in muscle cells from intake (and lipogenesis) to FA metabolism in both normal and insulin-resistant muscle cells. The scientific results gleaned from this research will provide new data about FA packaging into LDs and FA metabolism upon triggered lipolysis as a function of insulin activity levels. Furthermore, experiments investigating LD proximity to mitochondria in normal and insulin-resistant muscle cells will provide much needed data to help unravel the “athletes paradox” outlined above. The outcome of the PI’s research plan will reveal a link between FA processing and insulin resistance, which is critical for design of new therapeutics to treat type 2 diabetes.'