BIOPROBE

"VERTICAL MICROFLUIDIC PROBE: A nanoliter ""Swiss army knife"" for chemistry and physics at biological interfaces"

Coordinatore	IBM RESEARCH GMBH    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	1˙488˙600 €
EC contributo	1˙488˙600 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111109
Funding Scheme	ERC-SG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-01   -   2017-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	IBM RESEARCH GMBH  Organization address address: SAEUMERSTRASSE 4 city: RUESCHLIKON postcode: 8803 contact info Titolo: Dr. Nome: Govindkrishna Govind Cognome: Kaigala Email: send email Telefono: +41 44 724 8929 Fax: +41 44 724 8965	CH (RUESCHLIKON)	hostInstitution	1˙488˙600.00
2	IBM RESEARCH GMBH  Organization address address: SAEUMERSTRASSE 4 city: RUESCHLIKON postcode: 8803 contact info Titolo: Ms. Nome: Catherine Cognome: Trachsel Email: send email Telefono: +41 44 724 8289 Fax: +41 44 724 8578	CH (RUESCHLIKON)	hostInstitution	1˙488˙600.00

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 Obiettivo del progetto (Objective)

'Life is fundamentally characterised by order, compartmentalisation and biochemical reactions, which occurs at the right place right time – within, on the surface and between cells. Only a proportion of life processes can be addressed with contemporary approaches like liquid encapsulations (e.g. droplets) or engineering compartments (e.g. scaffolds). I believe these approaches are severely limited. I am convinced that a technique to study, work and locally probe adherent cells & tissues at micrometer distances from cell surfaces in “open space” would represent a major advance for the biology of biointerfaces. I therefore propose a non-contact, scanning technology, which spatially confines nanoliter volumes of chemicals for interacting with cells at the µm-length scale. This technology called the vertical microfluidic probe (vMFP) – that I developed at IBM-Zurich – shapes liquid on surfaces hydrodynamically and is compatible with samples on Petri dishes & microtiter plates. The project is organized in 4 themes:

(1) Advancing the vMFP by understanding the interaction of liquid flows with biointerfaces, integrating functional elements (e.g. heaters/electrodes, cell traps) & precision control. (2) Developing a higher resolution method to stain tissue sections for multiple markers & better quality information. (3) Retrieving rare elements such as circulating tumor cells from biologically diverse libraries. (4) Patterning cells for applications in regenerative medicine.

Since cells & tissues will no longer be limited by closed systems, the vMFP will enable a completely new range of experiments to be performed in a highly interactive, versatile & precise manner – this approach departs from classical “closed” microfluidics. It is very likely that such a tool by providing multifunctional capabilities akin to the proverbial ‘Swiss army knife’ will be a unique facilitator for investigations of previously unapproachable problems in cell biology & the life science.'