SENATOR
Development and clinical trials of a new Software ENgine for the Assessment & Optimization of drug and non-drug Therapy in Older peRsons
| Coordinatore | UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Organization address
address: Western Road contact info |
| Nazionalità Coordinatore | Ireland [IE] |
| Sito del progetto | http://www.senator-project.eu/ |
| Totale costo | 7˙810˙964 € |
| EC contributo | 5˙938˙947 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2012-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-10-01 - 2017-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Organization address
address: Western Road contact info |
IE (CORK) | coordinator | 1˙749˙183.86 |
| 2 |
ISTITUTO NAZIONALE DI RIPOSO E CURA PER ANZIANI INRCA
Organization address
address: Via Santa Margherita 5 contact info |
IT (ANCONA) | participant | 634˙800.00 |
| 3 |
SERVICIO MADRILENO DE SALUD
Organization address
address: PLAZA CARLOS TRIAS BERTRAN 7 contact info |
ES (MADRID) | participant | 599˙819.00 |
| 4 |
GRAMPIAN HEALTH BOARD
Organization address
address: EDAY ROAD 2 SUMMERFIELD HOUSE contact info |
UK (ABERDEEN) | participant | 598˙787.00 |
| 5 |
HELIX HEALTH LTD
Organization address
address: LAKE DRIVE 3094 CITYWEST BUSINESS contact info |
IE (DUBLIN) | participant | 584˙994.00 |
| 6 |
LANDSPITALI UNIVERSITY HOSPITAL
Organization address
address: Eiriksgata 5 contact info |
IS (REYKJAVIK) | participant | 519˙924.00 |
| 7 |
UNIVERSITEIT GENT
Organization address
address: SINT PIETERSNIEUWSTRAAT 25 contact info |
BE (GENT) | participant | 506˙243.00 |
| 8 |
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O
Organization address
address: Oskar-von-Miller-Ring 29 contact info |
DE (MUENCHEN) | participant | 300˙000.00 |
| 9 |
UNIVERSITY OF EAST ANGLIA
Organization address
address: EARLHAM ROAD contact info |
UK (NORWICH) | participant | 180˙000.00 |
| 10 |
SYDDANSK UNIVERSITET
Organization address
address: CAMPUSVEJ 55 contact info |
DK (ODENSE M) | participant | 168˙186.00 |
| 11 |
CLININFO S.A.
Organization address
address: RUE DE GERLAND- ENTREE 7 99 contact info |
FR (LYON) | participant | 73˙800.00 |
| 12 |
HASKOLI ISLANDS
Organization address
address: Sudurgata contact info |
IS (REYKJAVIK) | participant | 23˙210.14 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'The European population of older people with multiple chronic diseases (multimorbidity) is increasing steadily in tandem with the rising population of people aged ≥ 65 years. Older multimorbid people are at high risk of polypharmacy (PP), inappropriate prescribing (IP), adverse drug reactions (ADRs) and adverse drug events (ADEs). PP, IP, ADRs and ADEs in turn cause excessive drug costs and excess healthcare utilization; ADRs and ADEs also cause significant mortality. The current rapid rise in drug expenditure relating mostly to drug use by older people across Europe is not economically sustainable. In tandem with the drug therapy problems, there is underuse of non-drug therapies i.e. physiotherapy, occupational therapy, speech & language therapy, nutritional therapy, psychotherapy in the treatment of chronic diseases in this cohort. Optimal management of drug and non-drug therapy in older multimorbid persons usually requires specialist skill, but most doctors who treat older people do not have specialist training in Geriatric Medicine. To address these challenges, we propose to design and build a software engine (SENATOR) with the capacity to optimize therapy and simultaneously minimize ADRs, IP, PP and excessive cost. SENATOR will evaluate drug indications and contraindications, ADR/ADE risk and detect IP using validated criteria. SENATOR will identify cheapest drug brands to minimize cost. SENATOR will also recommend appropriate symptom-focused drug therapy and avoidance of drugs unlikely to be beneficial in frailer older people with low one year life expectancy. In addition, SENATOR will provide specific advice on appropriate non-drug therapies for individual patients. To test SENATOR’s efficacy, we will perform a multicentre RCT involving 1800 older multimorbid patients hospitalized with acute illness under the care of specialists other than geriatricians, using ADR incidence, medication appropriateness and drug/healthcare costs as the main outcome measures.'
Introduzione (Teaser)
Ageing is usually accompanied by multimorbidities, making clinical management a more complex task. The incidence of adverse drug reactions (ADRs) through prescription of potentially inappropriate medications is steadily rising as a result.