DiscoGnosis

Disc-shaped point-of-care platform for infectious disease diagnosis

Coordinatore	ALBERT-LUDWIGS-UNIVERSITAET FREIBURG    more  Organization address address: Georges Koehler Allee 103 city: Freiburg postcode: 79110 contact info Nome: Melanie Cognome: Baumann Email: send email Telefono: +49 761 203 73211 Fax: +49 761 203 73299
Nazionalità Coordinatore	Germany [DE]
Totale costo	3˙812˙406 €
EC contributo	2˙922˙000 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2011-8
Funding Scheme	CP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-11-01   -   2015-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ALBERT-LUDWIGS-UNIVERSITAET FREIBURG  Organization address address: Georges Koehler Allee 103 city: Freiburg postcode: 79110 contact info Nome: Melanie Cognome: Baumann Email: send email Telefono: +49 761 203 73211 Fax: +49 761 203 73299	DE (Freiburg)	coordinator	0.00
2	EUROPAISCHE STIFTUNG FUR KLINISCHE NANOMEDIZIN  Organization address address: ALEMANNENGASSE 12 city: BASEL postcode: 4016 contact info Titolo: Mr. Nome: Beat Cognome: Löffler Email: send email Telefono: 41616959395 Fax: 41616959390	CH (BASEL)	participant	0.00
3	MAGNAMEDICS DIAGNOSTICS BV  Organization address address: BURG LEMMENSSTRAAT 366 city: GELEEN postcode: 6163 JT contact info Titolo: Dr. Nome: Sven Cognome: Goethel Email: send email Telefono: 31468200206 Fax: 31464106825	NL (GELEEN)	participant	0.00
4	MAST GROUP LIMITED  Organization address address: MAST HOUSE - DERBY ROAD city: BOOTLE - LIVERPOOL postcode: L20 1EA contact info Titolo: Mrs. Nome: Liz Cognome: Gillies Email: send email Telefono: 441519000000 Fax: 441519000000	UK (BOOTLE - LIVERPOOL)	participant	0.00
5	ROHRER AG WERKZEUG- & MASCHINENBAU  Organization address address: BREMENSTALLSTRASSE 1 city: MOHLIN postcode: 4313 contact info Titolo: Mr. Nome: Hans Cognome: Peter Email: send email Telefono: 41618552185 Fax: 41618552190	CH (MOHLIN)	participant	0.00
6	THE UNIVERSITY OF STIRLING  Organization address city: STIRLING postcode: FK9 4LA contact info Titolo: Mr. Nome: Eric Cognome: Gibb Email: send email Telefono: 441786000000 Fax: 441786000000	UK (STIRLING)	participant	0.00
7	UNIVERSITATSSPITAL BASEL  Organization address address: Hebelstrasse 34 city: BASEL postcode: 4031 contact info Titolo: Prof. Nome: Patrick Cognome: Hunziker Email: send email Telefono: 41612655581	CH (BASEL)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

The project aims to develop a fully integrated, automated and user-friendly platform for infectious disease diagnosis. Malaria can be treated in just 48 hours, but delayed or false diagnosis or missing a relevant alternative cause of fever may be lethal. Therefore, other diseases with similar clinical symptoms will be investigated too. DiscoGnosis will integrate micro, nano, and bio components into a multi-functional point-of-care platform, performing simultaneously protein and genetic analysis to timely and accurately identify major pathogenic causes of fever, enabling proper treatment. A foil-based centrifugal microfluidic lab-on-a-chip cartridge, core of the platform, will integrate monolithically all necessary unit operations for raw sample treatment (blood-to-result regime), from sample collection and injection, to plasma separation, DNA extraction and purification. Low-cost production, scalable from prototype to batch fabrication (with proper quality control, calibration and standards specifications) will render the platform affordable to end users, even in developing countries; high sensitivity detection and multiplexity will rely on magnetic microparticles and quantum dot technologies, supported by dedicated optics development; rapid analysis (~30 min) will be achieved via isothermal DNA amplification protocols. The entire system will be validated in a controlled field test with standardized samples and by end-users in high-risk developing countries through partners' established contacts. Data management will be implemented to allow rational organization in the field and to reinforce the 'shield' of Europe against such diseases, as more than 30,000 malaria cases are reported annually among returning European tourists. This generic point-of-care platform can be applied to many diseases (eg, cancer, cardiovascular, Alzheimer) by only changing its bio-components. The strong SME participation indicates the high commercialization potential of the project.