DiscoGnosis
Disc-shaped point-of-care platform for infectious disease diagnosis
| Coordinatore | ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Organization address
address: Georges Koehler Allee 103 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 3˙812˙406 € |
| EC contributo | 2˙922˙000 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2011-8 |
| Funding Scheme | CP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-11-01 - 2015-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Organization address
address: Georges Koehler Allee 103 contact info |
DE (Freiburg) | coordinator | 0.00 |
| 2 |
EUROPAISCHE STIFTUNG FUR KLINISCHE NANOMEDIZIN
Organization address
address: ALEMANNENGASSE 12 contact info |
CH (BASEL) | participant | 0.00 |
| 3 |
MAGNAMEDICS DIAGNOSTICS BV
Organization address
address: BURG LEMMENSSTRAAT 366 contact info |
NL (GELEEN) | participant | 0.00 |
| 4 |
MAST GROUP LIMITED
Organization address
address: MAST HOUSE - DERBY ROAD contact info |
UK (BOOTLE - LIVERPOOL) | participant | 0.00 |
| 5 |
ROHRER AG WERKZEUG- & MASCHINENBAU
Organization address
address: BREMENSTALLSTRASSE 1 contact info |
CH (MOHLIN) | participant | 0.00 |
| 6 |
THE UNIVERSITY OF STIRLING
Organization address
city: STIRLING contact info |
UK (STIRLING) | participant | 0.00 |
| 7 |
UNIVERSITATSSPITAL BASEL
Organization address
address: Hebelstrasse 34 contact info |
CH (BASEL) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
The project aims to develop a fully integrated, automated and user-friendly platform for infectious disease diagnosis. Malaria can be treated in just 48 hours, but delayed or false diagnosis or missing a relevant alternative cause of fever may be lethal. Therefore, other diseases with similar clinical symptoms will be investigated too. DiscoGnosis will integrate micro, nano, and bio components into a multi-functional point-of-care platform, performing simultaneously protein and genetic analysis to timely and accurately identify major pathogenic causes of fever, enabling proper treatment. A foil-based centrifugal microfluidic lab-on-a-chip cartridge, core of the platform, will integrate monolithically all necessary unit operations for raw sample treatment (blood-to-result regime), from sample collection and injection, to plasma separation, DNA extraction and purification. Low-cost production, scalable from prototype to batch fabrication (with proper quality control, calibration and standards specifications) will render the platform affordable to end users, even in developing countries; high sensitivity detection and multiplexity will rely on magnetic microparticles and quantum dot technologies, supported by dedicated optics development; rapid analysis (~30 min) will be achieved via isothermal DNA amplification protocols. The entire system will be validated in a controlled field test with standardized samples and by end-users in high-risk developing countries through partners' established contacts. Data management will be implemented to allow rational organization in the field and to reinforce the 'shield' of Europe against such diseases, as more than 30,000 malaria cases are reported annually among returning European tourists. This generic point-of-care platform can be applied to many diseases (eg, cancer, cardiovascular, Alzheimer) by only changing its bio-components. The strong SME participation indicates the high commercialization potential of the project.