PRIMA-EDS

Polypharmacy in chronic diseases: Reduction of Inappropriate Medication and Adverse drug events in elderly populations by electronic Decision Support

Coordinatore	Private Universitaet Witten/Herdecke gGmbH    more  Organization address address: Alfred-Herrhaussen Strasse 50 city: WITTEN postcode: 58448 contact info Titolo: Prof. Nome: Andreas Cognome: Sönnichsen Email: send email Telefono: 492303000000 Fax: 492303000000
Nazionalità Coordinatore	Germany [DE]
Sito del progetto	http://www.prima-eds.eu
Totale costo	5˙960˙344 €
EC contributo	4˙618˙515 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-12-01   -   2016-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Private Universitaet Witten/Herdecke gGmbH  Organization address address: Alfred-Herrhaussen Strasse 50 city: WITTEN postcode: 58448 contact info Titolo: Prof. Nome: Andreas Cognome: Sönnichsen Email: send email Telefono: 492303000000 Fax: 492303000000	DE (WITTEN)	coordinator	1˙239˙141.00
2	KUSTANNUS OY DUODECIM  Organization address address: Kalevankatu 20 city: Helsinki postcode: 101 contact info Titolo: Prof. Nome: Ilkka Antero Cognome: Kunnamo Email: send email Telefono: 358505000000	FI (Helsinki)	participant	882˙048.00
3	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Prof. Nome: Aneez Cognome: Esmail Email: send email Telefono: 441613000000	UK (MANCHESTER)	participant	714˙738.00
4	UNIVERSITATSMEDIZIN ROSTOCK  Organization address address: SCHILLINGALLEE 35 city: ROSTOCK postcode: 18055 contact info Titolo: Prof. Nome: Attila Cognome: Altiner Email: send email Telefono: 493815000000 Fax: 493815000000	DE (ROSTOCK)	participant	654˙846.00
5	PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG  Organization address address: STRUBERGASSE 21 city: SALZBURG postcode: 5020 contact info Titolo: Dr. Nome: Tim Cognome: Johansson Email: send email Telefono: 436624000000000 Fax: 436624000000000	AT (SALZBURG)	participant	603˙400.00
6	SUDRITOLER AKADEMIE FUR ALLGEMEINMEDIZIN STIFTUNG ACCADEMIA ALTOATESINA DI MEDICINA GENERALE FONDAZIONE SAKAM ACAMG  Organization address address: VIA DEI VANGA 18 city: BOLZANO postcode: 39100 contact info Titolo: Dr. Nome: Giuliano Cognome: Piccoliori Email: send email Telefono: 390472000000 Fax: 390472000000	IT (BOLZANO)	participant	524˙342.00

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 Obiettivo del progetto (Objective)

'Background: Treatment of chronic diseases in the elderly with polypharmacy poses a threat to patient outcome and involves extensive costs. Little evidence exists regarding the benefits of polypharmacy, but rising evidence shows its harmful effects. Several approaches to reduce polypharmacy have been proposed, but none have been evaluated using clinically relevant endpoints. Aims: Based on a systematic review we will gather current best evidence and develop recommendations to optimize treatment of polymorbid elderly with cardiovascular disease, heart failure, hypertension, atrial fibrillation, diabetes mellitus type 2, musculoskeletal disorders, COPD, and mental diseases. We will then design an electronic decision support (eDS) tool incorporating the recommendations to be applied in primary care. The tool will be evaluated in a randomised controlled trial (RCT) to show that reduction of polypharmacy in the treatment of the target-diseases is beneficial and safe. Using the results of the RCT, the eDS-tool will be optimized and then disseminated for general utilization. Workplan: The project is scheduled for 4 years and will contain 12 work packages. WP1 comprises management of the project. The evidence regarding treatment of chronic diseases gathered within WP2 will be used to develop the eDS tool and an electronic case report form (eCRF) in WPs 3-4. After recruitment of surgeries and patients, and implementation of the tool in WP 5, the tool will be evaluated within a cluster-randomized controlled trial (WPs 6-10). The results of the RCT will be used to optimize the eDS tool (WP 11) which will then be disseminated (WP 12). Impact: The project will contribute to the EIP “Active and Healthy Ageing”. It will improve treatments suited to the needs of older people and lower health care costs by promoting standardized care and reducing hospital admissions. The tool will be exploited by one of the partners (Duodecim Medical Publications) to achieve widespread implementation'