PHOTONAVINET

Photoreception in Drosophila larvae: Information coding in a simple neuronal circuit

Coordinatore	UNIVERSITE DE FRIBOURG    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	1˙491˙873 €
EC contributo	1˙491˙873 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111109
Funding Scheme	ERC-SG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-01   -   2017-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE FRIBOURG  Organization address address: AVENUE DE L'EUROPE 20 city: FRIBOURG postcode: 1700 contact info Titolo: Mrs. Nome: Monique Cognome: Bersier Email: send email Telefono: +41 26 300 7003 Fax: +41 26 300 9600	CH (FRIBOURG)	hostInstitution	1˙491˙873.00
2	UNIVERSITE DE FRIBOURG  Organization address address: AVENUE DE L'EUROPE 20 city: FRIBOURG postcode: 1700 contact info Titolo: Prof. Nome: Simon Cognome: Sprecher Email: send email Telefono: +41 26 300 8901 Fax: +41 26 300 9741	CH (FRIBOURG)	hostInstitution	1˙491˙873.00

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 Obiettivo del progetto (Objective)

'How does the neuronal network of the brain mediate its function? This fundamental question in biology is still a puzzle, despite decades of intensive work. A seemingly unsolvable obstacle when studying the brain is its enormous complexity. A powerful approach to understand our brain uses “simple” brains of animal models, in which one can genetically identify and manipulate neurons. The brain of the fruit fly Drosophila melanogaster is widely used as an impacting model system to study how the brain functions with the advantage that the fly brain is much simpler compared to the mammalian brain. Even another one order of magnitude simpler is the brain of the Drosophila larva consisting of an estimated 10’000 neurons. We use the Drosophila larva as an excellent model to genetically dissect a comparably simple visual system. The eye of the larva consists only of two types of photoreceptor neurons: four blue-sensitive cells expressing Rhodopsin5 (Rh5) and eight green-sensitive cells expressing Rhodpsin6 (Rh6). The photoreceptors transmit the information to a small set of target neurons in the larval optic neuropil (LON). We found that only 12-15 brain interneurons connect to the LON, which can be classified in four different groups, according to location and neurotransmitter they use. The goal of this project is to dissect neuronal circuits of visual information processing: from mapping synaptic connections in the circuit to the behavioural impact of neurons. Preliminary results of my laboratory and a “step-by-step strategy” support the feasibility to reach these ambitious goals (Sprecher et al., 2011; Von Essen et al., 2011, Keene et al., 2011).'