IMPACT

Improving the lives of Parkinson’s Disease patients while reducing side-effects through tailored deep brain stimulation

Coordinatore	SAPIENS STEERING BRAIN STIMULATION BV    more  Organization address address: High Tech Campus 41 city: Eindhoven postcode: 5656 AE contact info Titolo: Mr. Nome: Daniel Cognome: Schobben Email: send email Telefono: 31634925738
Nazionalità Coordinatore	Netherlands [NL]
Sito del progetto	http://www.csr-impact.eu
Totale costo	6˙469˙220 €
EC contributo	4˙980˙907 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-09-01   -   2016-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	SAPIENS STEERING BRAIN STIMULATION BV  Organization address address: High Tech Campus 41 city: Eindhoven postcode: 5656 AE contact info Titolo: Mr. Nome: Daniel Cognome: Schobben Email: send email Telefono: 31634925738	NL (Eindhoven)	coordinator	1˙684˙200.00
2	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Mr. Nome: Christoph Cognome: Schulte Email: send email Telefono: +49 89 1205 2728 Fax: +49 89 1205 7534	DE (MUENCHEN)	participant	619˙050.00
3	INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FONDATION  Organization address address: BOULEVARD DE L'HOPITAL 47 city: PARIS postcode: 75013 contact info Titolo: Mr. Nome: Alexis Cognome: Genin Email: send email Telefono: 33157274050	FR (PARIS)	participant	560˙880.00
4	ICSENSE  Organization address address: GASTON GEENSLAAN 9 city: LEUVEN (HEVERLEE) postcode: 3001 contact info Titolo: Dr. Nome: Bram Cognome: De Muer Email: send email Telefono: +32 16 589702	BE (LEUVEN (HEVERLEE))	participant	502˙215.00
5	KLINIKUM DER UNIVERSITAET ZU KOELN  Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 contact info Titolo: Prof. Nome: Lars Cognome: Timmermann Email: send email Telefono: +49 221 478 7494	DE (KOELN)	participant	482˙000.00
6	LINKOPINGS UNIVERSITET  Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 contact info Titolo: Mr. Nome: Jörgen Cognome: Jonson Email: send email Telefono: +46 13 286736 Fax: +46 13 101902	SE (LINKOPING)	participant	402˙400.00
7	TWENTE MEDICAL SYSTEMS INTERNATIONAL B.V.  Organization address address: ZUTPHENSTRAAT 57 city: OLDENZAAL postcode: 7575 EJ contact info Titolo: Mr. Nome: Marcel Cognome: Braamhaar Email: send email Telefono: +31 541 534603	NL (OLDENZAAL)	participant	399˙960.00
8	VASTERBOTTENS LANS LANDSTING  Organization address address: Koksvagen 11 city: UMEA postcode: 90189 contact info Titolo: Prof. Nome: Patric Cognome: Blomstedt Email: send email Telefono: 46907852705 Fax: 4690138370	SE (UMEA)	participant	330˙202.00

Mappa

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 Obiettivo del progetto (Objective)

'The IMPACT project is about improving the lives of brain diseased patients through a novel approach that leaps beyond currently available Deep Brain Stimulation (DBS) devices and procedures. The initial project focus is on Parkinson’s Disease (PD), but further brain-disease indications will be included in the later phase of the project. The personalized approach that IMPACT brings is essential in delivering full therapeutic benefits to DBS patients while preventing the stimulation-induced side-effects that occur with today's DBS implants.

PD is well known for its characteristic symptoms: shaking, rigidity, slowness of movement and postural instability. Millions are suffering from PD including famous people like Michael J. Fox. Drugs are used as first treatment, but as the disease progresses they become ineffective and increasingly higher doses are needed. This leads to many side-effects, while symptoms still persist.

DBS is a ‘pacemaker for the brain’, analogous to the function of pacemakers for the heart: mild electrical stimuli are delivered to brain tissue to suppress unwanted activity and restore desired neuronal functions. When stimulation is optimal, the impact of DBS is spectacular: shaking and rigidity are strongly improved, and medication doses may be lowered significantly.

Despite its successes, DBS is still in its infancy. Programming for optimal therapy is complicated since physicians lack the appropriate tools to support them. Around 15 – 30% of DBS patients suffer from stimulation-induced side-effects resulting from stimulation leaking outside intended target regions. IMPACT addresses these barriers to adoption exploiting the directivity provided by next generation high-resolution implants.

IMPACT delivers a physician tool for tuning the high-resolution implant based on a personalized patient brain stimulation model that takes into account imaging data (MRI, X-ray) as well as pre-operative data (local field potentials).'