MODICELL

Targeted Modulation of Immune-System Responses in Cell Therapies

Coordinatore	ST. ANNA KINDERKREBSFORSCHUNG    more  Organization address address: ZIMMERMANNPLATZ 10 city: WIEN postcode: 1090 contact info Titolo: Dr. Nome: Nuno Cognome: Andrade Email: send email Telefono: 431405000000 Fax: 4314050000000
Nazionalità Coordinatore	Austria [AT]
Totale costo	886˙903 €
EC contributo	886˙903 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IAPP
Funding Scheme	MC-IAPP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-01   -   2016-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ST. ANNA KINDERKREBSFORSCHUNG  Organization address address: ZIMMERMANNPLATZ 10 city: WIEN postcode: 1090 contact info Titolo: Dr. Nome: Nuno Cognome: Andrade Email: send email Telefono: 431405000000 Fax: 4314050000000	AT (WIEN)	coordinator	300˙859.00
2	SIGNIFICO RESEARCH OY  Organization address address: ORIONINKATU 6 A 12 city: HELSINKI postcode: 550 contact info Titolo: Ms. Nome: Sirkku Cognome: Karinen Email: send email Telefono: 358443000000	FI (HELSINKI)	participant	329˙228.00
3	ACTIVARTIS BIOTECH GMBH  Organization address address: ZIMMERMANNPLATZ 10 city: WIEN postcode: 1090 contact info Titolo: Dr. Nome: Thomas Cognome: Felzmann Email: send email Telefono: +43 1 40470 4080	AT (WIEN)	participant	141˙024.00
4	BAR ILAN UNIVERSITY  Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 contact info Titolo: Ms. Nome: Estelle Cognome: Waise Email: send email Telefono: 97235317439 Fax: 97236353277	IL (RAMAT GAN)	participant	115˙792.00

Mappa

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 Obiettivo del progetto (Objective)

'Cell-based immunotherapies are a modern treatment approach holding promise to utilize nature’s own power to treat diseases that develop on the ground of immune system aberrations. Such diseases include cancer that develops and progresses via immune escape and on the other hand rejection of transplanted organs that need to be accepted by the immune system. Because the functions of distinct immune cell populations are highly plastic and interdependent, a better understanding of the complex regulation of immune system responses is indispensable for the optimization of cell therapies. The central goal of MODICELL therefore is to learn how to effectively instruct immune cells prior to being transferred to excite immune system responses tailored to patients’ needs. MODICELL will particularly seek to understand how to support immune activity in cancer patients by enhancing anti-cancer immunity and in transplantation immunology by inducing controlled tolerance to prevent organ rejection. MODICELL will accomplish this goal by testing agent-based models in a multidisciplinary platform combining academic expertise and industrial know-how. One academic institution will provide computer modelling to generate predictions on the interaction of immune cells under various conditions, providing hits for the other partners to test. The SMEs will use different but complementary strategies for enhancing anti-cancer immune therapies. On the other side of the immune spectrum, another academic partner will focus at enhancing tolerance in transplantation. MODICELL’s approach will enable all partners to optimise and synergize efforts to reach their goals at covering a large range of immune system responses. Thus, MODICELL will provide a highly dynamic platform for expertise and knowledge transfer between distinct sectors that can only succeed by bridging human resources, technology and creativity from the academic and industrial backgrounds.'