IMMRSRGE
Identifying molecular mechanism responsible for spatial reorganisation of the genome during embryogenesis
| Coordinatore | THE UNIVERSITY OF EDINBURGH
Organization address
address: OLD COLLEGE, SOUTH BRIDGE contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 231˙283 € |
| EC contributo | 231˙283 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2012-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-04-01 - 2015-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE UNIVERSITY OF EDINBURGH
Organization address
address: OLD COLLEGE, SOUTH BRIDGE contact info |
UK (EDINBURGH) | coordinator | 231˙283.20 |
Mappa
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Obiettivo del progetto (Objective)
'Spatial organisation in the nucleus is not random and it has a role in genome regulation. Large blocks of heterochromatin accumulate at the nuclear envelope and positioning of genes at the nuclear periphery correlates with gene repression. However, this organisation is not fixed and nuclear reorganisation has been described during mammalian development. In the inner cell mass of the blastocyst, chromatin exists in an unusual configuration with apparently widely dispersed open chromatin fibres. Following implantation at the epiblast stage, several hundreds of genes relocate to the nuclear periphery, concomitant with the formation of large domains of heterochromatin there. Interestingly, in the same time, specific genes can also remove from the nuclear envelope to the centre of the nucleus which is associated to their activation. Subsequently, lineage-dependant changes occur during the next steps of development. However, the molecular mechanisms which control this reorganisation are not understood. Prevailing models assume some transacting factors are responsible for an active recruitment and tethering of specific domains to the nuclear envelope. Thus, I propose, using a candidate approach and a RNAi screen, to identify factors responsible for the nuclear reorganisation observed in EpiSCs and to also address an alternative hypothesis that I have proposed and which involves a more passive accumulation of heterochromatin at the nuclear periphery that is influenced by nuclear pore complexes.'
Introduzione (Teaser)
EU-funded researchers investigated genome regulation and protein folding in early mammalian development. Their work provides significant insight into genome function during early embryogenesis.