DEEPNMDAR

DEEP BRAIN TISSUE IMAGING OF GLUTAMATE NMDAR

Coordinatore	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE    more  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Gaelle Cognome: Bujan Email: send email Telefono: +33 5 57 35 58 58 Fax: +33 5 57 35 58 01
Nazionalità Coordinatore	France [FR]
Totale costo	194˙046 €
EC contributo	194˙046 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-07-01   -   2015-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Gaelle Cognome: Bujan Email: send email Telefono: +33 5 57 35 58 58 Fax: +33 5 57 35 58 01	FR (PARIS)	coordinator	194˙046.60

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 Obiettivo del progetto (Objective)

'Unrevealing the rules that govern the surface trafficking and membrane stabilization of neurotransmitter receptors, in particular the NMDAR is crucial for our understanding of several physiopathological brain processes. Over the past few years, scientists have shown that neurotransmitter receptors diffuse inside and out of synapses in cultured neurons using single molecule approaches. These findings drastically changed the way we understand synaptic transmission and adaptation. The proposed project aims to study the surface diffusion of NMDAR in intact hippocampal slices, providing the first functional map of such key receptors in native neuronal networks. Due to the difficulties of imaging single molecules in high background noise tissue, a multidisciplinary approach will be adopted using quantum dots and single walled nanotubes to track single NMDAR neurotransmitters. The success of the project will be a real breakthrough in neurobiology of synapses and in single molecule imaging techniques, conjugating state of the art knowledge in neurosciences and nanophotonics.'