THYMISTEM

Development of Stem Cell Based Therapy for Thymic Regeneration

Coordinatore	THE UNIVERSITY OF EDINBURGH    more  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 1316509024
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	7˙748˙982 €
EC contributo	5˙996˙455 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2013-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-10-01   -   2017-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 1316509024	UK (EDINBURGH)	coordinator	1˙838˙061.00
2	NANOPHARMA AS  Organization address address: NOVA 306 city: PARDUBICE postcode: 530 09 contact info Titolo: Ms. Nome: Katerina Cognome: Lajblova Email: send email Telefono: 420731000000	CZ (PARDUBICE)	participant	899˙472.94
3	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Ms. Nome: María ángeles Cognome: López Váquez Email: send email Telefono: +34 915681462 Fax: +34 915681573	ES (MADRID)	participant	750˙000.00
4	Sloan-Kettering Institute for Cancer Research CORPORATION  Organization address address: York Avenue 1275 city: New York postcode: 10065 contact info Titolo: Mr. Nome: Mark Cognome: Svenningson Email: send email Telefono: 16462273414 Fax: 12126398207	US (New York)	participant	749˙999.75
5	OPEN INTERNATIONAL UNIVERSITY OF HUMAN DEVELOPMENT UKRAINE  Organization address address: Khoryva 1-G city: Kyiv postcode: 4071 contact info Titolo: Prof. Nome: Valentin Cognome: Shichkin Email: send email Telefono: +38 097 5072932	UA (Kyiv)	participant	720˙000.20
6	YEDITEPE UNIVERSITY  Organization address address: Agustos Yerlesimi Kayisdagi Cad. 26 city: Istanbul postcode: 34755 contact info Titolo: Ms. Nome: Ozge Cognome: Kaya Email: send email Telefono: +90 2165780748 Fax: 902166000000	TR (Istanbul)	participant	538˙400.00
7	RUDER BOSKOVIC INSTITUTE  Organization address address: Bijenicka cesta 54 city: ZAGREB postcode: 10000 contact info Titolo: Ms. Nome: Marijana Cognome: Klasnic Kozar Email: send email Telefono: +385 14571342 Fax: 38514680250	HR (ZAGREB)	participant	500˙521.60

Mappa

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 Obiettivo del progetto (Objective)

'Reconstitution of immune system function in immunocompromised patients depends on the presence of a functional thymus, and specifically, on the diverse array of epithelial cells within the thymic stroma. The thymus is the first organ to degenerate in normal healthy individuals, and is also sensitive to cytotoxic interventions. Therefore lack of thymic function presents a serious problem for many patients. Transplantation of neonatal human thymus can lead to successful immune system reconstitution, but limited tissue supply prevents its widespread use. Thymic epithelial stem cells (TESC), which can generate all of the epithelial subpopulations of the adult thymus, present an alternative source of transplantable cells. However, protocols for growing or generating TESC in the laboratory have not yet been developed. This proposal aims to develop robust and scalable protocols for the long-term in vitro culture of functionally validated human TESC, including standardized quality controls, and to establish optimized means of delivering these cells to immunocompromised recipients such that thymus function is fully restored. It also aims to develop optimized procedures for cryopreservation of human thymic stromal cells. These objectives relate directly to the topic identified in call HEALTH.2013.1.4-1 Controlling differentiation and proliferation in human stem cells intended for therapeutic use. THYMISTEM brings together a strong, pan-European team comprising thymus and stem cell biologists, immunologists working in humanized mouse models, haematologists expert in immune reconstitution, tissue engineers, and experts in cryopreservation and cell banking, to deliver these goals. Overall, this work will build the preclinical foundations required for development of a novel stem-cell based therapy: transplantation of thymic epithelial stem cell-based organoids for regenerative recovery of thymic - and thus immune system - function in patients.'