OTOSTEM
Human stem cell applications for the treatment of hearing loss
| Coordinatore | EBERHARD KARLS UNIVERSITAET TUEBINGEN
Organization address
address: GESCHWISTER-SCHOLL-PLATZ contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 7˙892˙595 € |
| EC contributo | 5˙999˙784 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-11-01 - 2017-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Organization address
address: GESCHWISTER-SCHOLL-PLATZ contact info |
DE (TUEBINGEN) | coordinator | 847˙700.00 |
| 2 |
AUDION THERAPEUTICS BV
Organization address
address: LINNAEUSPARKWEG 10-2 contact info |
NL (AMSTERDAM) | participant | 712˙000.00 |
| 3 |
ACOUSIA THERAPEUTICS GMBH
Organization address
address: SINDELFINGER STRASSE 3 contact info |
DE (TUBINGEN) | participant | 678˙800.00 |
| 4 |
UNIVERSITAET BERN
Organization address
address: Hochschulstrasse 4 contact info |
CH (BERN) | participant | 647˙560.00 |
| 5 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Organization address
address: SERRA MALL 450 contact info |
US (STANFORD) | participant | 646˙750.00 |
| 6 |
THE UNIVERSITY OF SHEFFIELD
Organization address
address: FIRTH COURT WESTERN BANK contact info |
UK (SHEFFIELD) | participant | 629˙270.00 |
| 7 |
MASSACHUSETTS EYE AND EAR INFIRMARY
Organization address
address: CHARLES STREET SUITE 421 243 contact info |
US (BOSTON) | participant | 621˙750.00 |
| 8 |
UNIVERSITE D'AIX MARSEILLE
Organization address
address: Boulevard Charles Livon 58 contact info |
FR (Marseille) | participant | 565˙500.00 |
| 9 |
UPPSALA UNIVERSITET
Organization address
address: SANKT OLOFSGATAN 10 B contact info |
SE (UPPSALA) | participant | 490˙454.00 |
| 10 |
SCIPROM SARL
Organization address
address: RUE DU CENTRE 70 contact info |
CH (Saint-Sulpice) | participant | 160˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'Hearing impairment is the most frequent human sensory deficit and is mainly caused by the irreversible loss of neurosensory cells in the cochlea. The lack of human otic cell models represents a significant roadblock that has hampered the development of drug-based or cell-based therapies for the treatment of hearing loss. In a collaborative effort under this proposal we wish to devise approaches to generate human otic progenitors and differentiated otic cells from different human stem cell sources. We have devised guidance protocols for mouse and human embryonic and reprogrammed stem cells toward inner ear cell types that make use of principles of early germ layer formation and otic induction. A limitation is the efficacy of otic progenitor cell generation. Purification techniques for human otic progenitors from ES/iPS cell sources and in addition from native human otic tissues from fetal and adult stages will will serve the dual purpose for one to enable the development of novel bioassays for drug screens, as well as generating cells with decreased tumorigenicity for cell transplantation studies in in vivo animal models. New hit compounds identified from screening efforts will be tested and validated further in established organ culture models. The identification of relevant candidate compounds will be further developed as lead drug candidates in noise and ototoxic drug induced in vivo models. The scope of this stem cell technology development requires a collaborative team effort, with groups that have substantial combined experience in human ES/iPS cell work, inner ear stem cell biology, high-throughput assay development, and in translating research findings into the clinic as well as into the biotechnology realm. Within the consortium there exists an established translational route from bench to bedside for the commercial development of human otic stem cell derived technology towards inner ear medical applications aiming at the restoration of hearing function.'