AUTOFLOW

Automation of Flow Cytometric Analysis for Quality-Assured Follow-up Assessment to Guide Curative Therapy for Acute Lymphoblastic Leukaemia in Children

Coordinatore	TECHNISCHE UNIVERSITAET WIEN    more  Organization address address: Karlsplatz 13 city: WIEN postcode: 1040 contact info Titolo: Dr. Nome: Martin Cognome: Kampel Email: send email Telefono: +43 15880118364
Nazionalità Coordinatore	Austria [AT]
Totale costo	1˙638˙478 €
EC contributo	1˙638˙478 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IAPP
Funding Scheme	MC-IAPP
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-02-01   -   2018-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET WIEN  Organization address address: Karlsplatz 13 city: WIEN postcode: 1040 contact info Titolo: Dr. Nome: Martin Cognome: Kampel Email: send email Telefono: +43 15880118364	AT (WIEN)	coordinator	508˙605.25
2	INFOKOM Informations- und Kommunikationsgesellschaft mbH  Organization address address: JOHANNESSTRASSE 8 city: NEUBRANDENBURG postcode: 17034 contact info Titolo: Mr. Nome: Rolf-Dietrich Cognome: Berndt Email: send email Telefono: +49 395 430520	DE (NEUBRANDENBURG)	participant	368˙404.97
3	LABDIA LABORDIAGNOSTIK GMBH  Organization address address: ZIMMERMANNPLATZ 8 city: WIEN postcode: 1090 contact info Titolo: Dr. Nome: Michael Cognome: Dworzak Email: send email Telefono: +43 1404704441	AT (WIEN)	participant	303˙369.56
4	CogVis Software und Consulting GmbH  Organization address address: WIEDNER HAUPTSTRASSE 17 3 A city: WIEN postcode: 1040 contact info Titolo: Mr. Nome: Michael Cognome: Brandstötter Email: send email Telefono: +43 69919971594	AT (WIEN)	participant	266˙557.28
5	CHARITE - UNIVERSITAETSMEDIZIN BERLIN  Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 contact info Titolo: Ms. Nome: Martina Cognome: Eickmann Email: send email Telefono: +49 30 450576376 Fax: +49 30 450576954	DE (BERLIN)	participant	191˙541.90

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 Obiettivo del progetto (Objective)

'Acute Lymphoblastic Leukaemia is the most frequent leukaemia entity in children and adolescents. Despite continued progress and refinement of therapeutic approaches, disease relapse due to insufficient extinction of leukaemic blasts still remains the number one cause of treatment failure. About 15-20% of paediatric patients with the disease still suffer from relapse. Flow cytometry (FCM) is one of the methodologies most useful in this respect, because it is widely available and applicable to most patients. While sample preparation, antibody panels, staining procedures, and FCM acquisition can be harmonized straightforwardly, data analysis and interpretation rely largely on operator skills and experience. These assessments are time-consuming and costly to be attained via staff-training, online support between twinning laboratories, and continued quality control. Hence, these requirements represent the current bottleneck of safely applying the FCM-Minimal Residual Desease (MRD) methodology in a growing community of diagnostic laboratories to the benefit of an increasing number of patients with leukaemia. To address this bottleneck, AutoFLOW aims at developing an objective and automated tool for multi-parameter FCM data analysis with robust and reliable MRD quantification. The consortium aims at engaging professionals from the medical and ICT fields in a network where the exchange of knowledge will culminate in a valid solution for automated FCM analysis for clinical follow-up assessment of Acute Lymphoblastic Leukaemia (ALL). Additionally, AutoFLOW is expected to gain better career perspectives for the involved personnel and increase the competitiveness of the participating SMEs.'