OXYGREEN
Effective redesign of oxidative enzymes for green chemistry
| Coordinatore | RIJKSUNIVERSITEIT GRONINGEN
Organization address
address: Broerstraat 5 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Sito del progetto | http://www.rug.nl/oxygreen/index |
| Totale costo | 7˙435˙684 € |
| EC contributo | 5˙543˙249 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2007-1 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-05-01 - 2013-04-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
RIJKSUNIVERSITEIT GRONINGEN
Organization address
address: Broerstraat 5 contact info |
NL (GRONINGEN) | coordinator | 0.00 |
| 2 |
"BIOLOG LIFE SCIENCE INSTITUTE, FORSCHUNGSLABOR UND BIOCHEMICA- VERTRIEB GMBH"
Organization address
address: Flughafendamm 9a contact info |
DE (BREMEN) | participant | 0.00 |
| 3 |
BIOINFOBANK INSTITUTE
Organization address
address: Limanowskiego 24/a 16 contact info |
PL (POZNAN) | participant | 0.00 |
| 4 |
DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V.
Organization address
address: Theodor-Heuss-Allee 25 contact info |
DE (FRANKFURT) | participant | 0.00 |
| 5 |
DSM INNOVATIVE SYNTHESIS BV
Organization address
address: POSTSTRAAT 1 contact info |
NL (SITTARD) | participant | 0.00 |
| 6 |
DSM RESEARCH B.V.
Organization address
address: Urmonderbaan 22 contact info |
NL (GELEEN) | participant | 0.00 |
| 7 |
ENZYSCREEN
Organization address
address: Wassenaarseweg contact info |
NL (LEIDEN) | participant | 0.00 |
| 8 |
EVONIK REXIM
Organization address
address: Rue de Verdun 33 contact info |
FR (HAM) | participant | 0.00 |
| 9 |
JACOBS UNIVERSITY BREMEN GGMBH
Organization address
address: Campus Ring 1 contact info |
DE (BREMEN) | participant | 0.00 |
| 10 |
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Organization address
address: Templergraben 55 contact info |
DE (AACHEN) | participant | 0.00 |
| 11 |
TECHNISCHE UNIVERSITAET GRAZ
Organization address
address: Rechbauerstrasse 12 contact info |
AT (GRAZ) | participant | 0.00 |
| 12 |
TECHNISCHE UNIVERSITAET WIEN
Organization address
address: Karlsplatz 13 contact info |
AT (WIEN) | participant | 0.00 |
| 13 |
TECHNISCHE UNIVERSITAT DORTMUND
Organization address
address: AUGUST SCHMIDT STRASSE 4 contact info |
DE (DORTMUND) | participant | 0.00 |
| 14 |
UNIVERSITA DEGLI STUDI DI PAVIA
Organization address
address: STRADA NUOVA 65 contact info |
IT (PAVIA) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Enzymes are extremely powerful natural catalysts able to perform almost any type of chemical reaction while being mild by nature and highly specific. In fact, the delicate functioning of enzymes forms the basis of every living creature. The catalytic potential of enzymes is more and more appreciated by the industry as many industrial processes rely on these sophisticated catalysts. However, the number of reactions catalyzed by enzymes is restricted as enzymes only have evolved to catalyze reactions that are physiologically relevant. Furthermore, enzymes have adapted to the direct (cellular) environment in which they have to function (e.g. operative at ambient temperature, resilient towards proteolysis, catalytic turnover rate should fit with metabolic enzyme partners). This excludes the existence of enzymes that do not fit within boundaries set by nature. It is a great challenge to go beyond these natural boundaries and develop methodologies to design ‘unnatural’ tailor-made enzymes. Ideally it should become possible to (re)design enzymes to convert pre-defined substrates. Such designer enzymes could theoretically exhibit unsurpassed catalytic properties and, obviously, will be of significant interest for industrial biotechnology. The OXYGREEN project aims at the design and construction of novel oxygenating enzymes (designer oxygenases) for the production of compounds that can be used in medicine, food and agriculture and the development of novel powerful and generic enzyme redesign tools for this purpose. The enzymes and whole-cell biocatalysts that will be developed should catalyze the specific incorporation of oxygen to afford synthesis of bioactive compounds in a selective and clean way, with minimal side products and with no use of toxic materials. For this, generic platform technologies (novel high-throughput methodology and methods for engineering dedicated host cells) will be developed that allow effective structure-inspired directed evolution of enzyme.'
Introduzione (Teaser)
Enzymes act as catalysts in chemical reactions to produce useful chemicals. Selectively oxidative enzymes are particularly useful in industrial applications but issues with availability, reliability, yield and robustness need to be addressed.