CONTAMED
Contaminant mixtures and human reproductive health - novel strategies for health impact and risk assessment of endocrine disrupters
| Coordinatore | BRUNEL UNIVERSITY
Organization address
address: Kingston Lane contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 4˙584˙536 € |
| EC contributo | 3˙494˙352 € |
| Programma | FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change) |
| Code Call | FP7-ENV-2007-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-05-01 - 2012-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
BRUNEL UNIVERSITY
Organization address
address: Kingston Lane contact info |
UK (UXBRIDGE) | coordinator | 0.00 |
| 2 |
"THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON"
Organization address
address: Brunswick Square 29-39 contact info |
UK (LONDON) | participant | 0.00 |
| 3 |
DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
DK (KONGENS LYNGBY) | participant | 0.00 |
| 4 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | participant | 0.00 |
| 5 |
FAUST UND BACKHAUS ENVIRONMENTAL CONSULTING GBR
Organization address
address: FAHRENHEITSTRASSE 1 contact info |
DE (BREMEN) | participant | 0.00 |
| 6 |
GREEN TOX GMBH
Organization address
address: LANGACKERSTRASSE 49 contact info |
CH (ZURICH) | participant | 0.00 |
| 7 |
UNIVERSIDAD DE GRANADA
Organization address
address: CUESTA DEL HOSPICIO SN contact info |
ES (GRANADA) | participant | 0.00 |
| 8 |
UNIVERSITY OF BRISTOL
Organization address
address: TYNDALL AVENUE SENATE HOUSE contact info |
UK (BRISTOL) | participant | 0.00 |
| 9 |
UNIVERSITY OF SUSSEX
Organization address
address: Sussex House contact info |
UK (FALMER, BRIGHTON) | participant | 0.00 |
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Obiettivo del progetto (Objective)
'Disruption of hormonal signalling in fetal life can irreversibly affect human development and reproductive health at a later age. Of considerable concern in Europe is a decline in male semen quality and a high prevalence of congenital malformations and hormone-dependent cancers. Although it appears plausible that environmental chemicals with endocrine activity may be involved in the causation of these disorders, there is no evidence for adverse effects of individual substances at relevant human exposure levels. However, there are indications that combinations of chemicals play a cumulative role. CONTAMED aims to explore the hypothesis that combined exposure to endocrine disrupting chemicals in fetal life may lead to adverse delayed impacts on human reproductive health. To achieve this goal, CONTAMED will combine epidemiological approaches with laboratory science. The work plan for CONTAMED is organised in three major strands focusing on human studies, animal models and in vitro assays including metabolomics. The project will deliver new epidemiological insights into associations between cumulative exposure and reproductive health, improved toxicological risk assessment for the anticipation of reproductive effects of chemicals, validated biomarkers for cumulative exposures and new mechanistic information about the ways in which chemicals may disrupt sexual differentiation during development. CONTAMED will provide the knowledge necessary to set the scene for Europe-wide human health impact studies of cumulative exposures to endocrine active chemicals and their possible role in the deterioration of reproductive health in Europe. Finally, the project will analyze the implications of new scientific findings for the European Environment and Health Action Plan and the Community Strategy for Endocrine Disrupters.'
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