NEURONANO

Do nanoparticles induce neurodegenerative diseases? Understanding the origin of reactive oxidative species and protein aggregation and mis-folding phenomena in the presence of nanoparticles

Coordinatore	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN    more  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Mr. Nome: Donal Cognome: Doolan Email: send email Telefono: 35317161656 Fax: 35317161216
Nazionalità Coordinatore	Ireland [IE]
Sito del progetto	http://www.neuronano.eu
Totale costo	4˙823˙050 €
EC contributo	2˙498˙000 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2007-SMALL-1
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-01   -   2012-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Mr. Nome: Donal Cognome: Doolan Email: send email Telefono: 35317161656 Fax: 35317161216	IE (DUBLIN)	coordinator	884˙061.75
2	UNIVERSITY OF ULSTER  Organization address address: CROMORE ROAD city: COLERAINE postcode: BT52 1SA contact info Titolo: Dr. Nome: Anne Marie Cognome: Patton Email: send email Telefono: +44 28 7032 3383 Fax: +44 2870 32 4922	UK (COLERAINE)	participant	420˙617.00
3	JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION  Organization address address: Rue de la Loi 200 city: BRUSSELS postcode: 1049 contact info Titolo: Mr. Nome: Raymond Cognome: Crandon Email: send email Telefono: +39 0332 78 9828 Fax: +39 0332 78 9717	BE (BRUSSELS)	participant	352˙200.00
4	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Juergen Cognome: Ertel Email: send email Telefono: -6249 Fax: -7093	DE (MUENCHEN)	participant	337˙500.00
5	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 650 9023	UK (EDINBURGH)	participant	251˙621.25
6	UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK  Organization address address: Western Road city: CORK postcode: - contact info Titolo: Prof. Nome: Pater Cognome: Kennedy Email: send email Telefono: +353 21 4903500 Fax: +353 21 4903506	IE (CORK)	participant	167˙000.00
7	UNIVERSIDADE FEDERAL DO CEARA  Organization address address: AVENIDA DA UNIVERSIDADE 2853 city: FORTALEZA postcode: 60020181 contact info Titolo: Dr. Nome: Francisco Antonio Cognome: Guimaraes Email: send email Telefono: +55 85 3281 3444 Fax: +55 85 3243 5381	BR (FORTALEZA)	participant	85˙000.00
8	NATIONAL INSTITUTE FOR MATERIALS SCIENCE  Organization address address: SENGEN 1-2-1 city: TSUKUBA postcode: 305 0047 contact info Titolo: Mr. Nome: Masahiro Cognome: Takemura Email: send email Telefono: +81 29 859 2402 Fax: +81 29 859 2049	JP (TSUKUBA)	participant	0.00
9	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA  Organization address address: "FRANKLIN STREET 1111, 12 FLOOR" city: OAKLAND CA postcode: 94607 contact info Titolo: Ms. Nome: Evelyn Cognome: Balabis Email: send email Telefono: +1 310 794 2838 Fax: +1 310 794 2852	US (OAKLAND CA)	participant	0.00
10	UNIVERSITY OF ROCHESTER  Organization address address: "ELMWOOD AVENUE, BOX EHSC 601" city: ROCHESTER NY postcode: 14642 contact info Titolo: Dr. Nome: Jane Cognome: Tolbert Email: send email Telefono: +1 585 275 4210 Fax: +1 585 275 9492	US (ROCHESTER NY)	participant	0.00
11	WILLIAM MARSH RICE UNIVERSITY  Organization address address: MAIN STREET 6100 city: HOUSTON TEXAS postcode: 77005 contact info Titolo: Ms. Nome: Nancy Cognome: Nisbett Email: send email Telefono: +1 713 348 6200 Fax: +1 713 348 5425	US (HOUSTON TEXAS)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'As the use of nanoparticles becomes more prevalent, it is clear that human exposure will inevitably increase. Considering the rapidly ageing European population and the resulting increase in the incidence of neurodegenerative diseases, there is an urgent need to address the risk presented by nanoparticles towards neurodegenerative diseases. It is believed that nanoparticles can pass through the blood-brain barrier. Once in the brain, nanoparticles have two potential major effects. They can induce oxidative activity (production of Reactive Oxygen Species), and can induce anomalous protein aggregation behaviour (fibrillation). There are multiple disease targets for the nanoparticles, including all of the known fibrillation diseases (e.g. Alzheimer’s and Parkinson’s diseases). The factors that determine which nanoparticles enter the brain are not known. Nanoparticle size, shape, rigidity and composition are considered important, and under physiological conditions, the nature of the adsorbed biomolecule corona (proteins, lipids etc.) determines the biological responses. The NeuroNano project will investigate the detailed mechanisms of nanoparticle passage through the blood-brain barrier using primary cell co-cultures and animal studies. Using nanoparticles that are shown to reach the brain, we will determine the mechanisms of ROS production and protein fibrillation, using state-of-the-art approaches such as redox proteomics and isolation/characterisation of the critical pre-fibrillar species. Animal models for Alzheimer’s diseases will confirm the effects of the nanoparticles in vivo. At all stages the exact nature of the nanoparticle biomolecule corona will be determined. The result will be a risk-assessment framework for assessing the safety of nanoparticles towards neurodegenerative diseases, based on the connection of their biological effects to their biomolecule corona, which determines the biological response in vivo and reports on the nanoparticles’ history.'

Introduzione (Teaser)

Engineered nanoparticles (NPs) are miniature entities of materials also manufactured in bulk but with very different properties. As their prevalence increases, it is critical to evaluate the potential impact on public health.