FOLDAPPI

Foldamers against protein-protein interactions

Coordinatore	UNIVERSITE DE BORDEAUX    more  Organization address address: PLACE PEY BERLAND 35 city: BORDEAUX postcode: 33000 contact info Titolo: Ms. Nome: Patricia Cognome: Dulor Email: send email Telefono: +33 5 40 00 68 02 Fax: +33 5 40 00 22 00
Nazionalità Coordinatore	France [FR]
Totale costo	1˙089˙570 €
EC contributo	1˙089˙570 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IAPP-2008
Funding Scheme	MC-IAPP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-01   -   2014-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE BORDEAUX  Organization address address: PLACE PEY BERLAND 35 city: BORDEAUX postcode: 33000 contact info Titolo: Ms. Nome: Patricia Cognome: Dulor Email: send email Telefono: +33 5 40 00 68 02 Fax: +33 5 40 00 22 00	FR (BORDEAUX)	coordinator	0.00
2	UNIVERSITE BORDEAUX I  Organization address address: 351 Cours de la Liberation city: TALENCE postcode: 33405 contact info Titolo: Ms. Nome: Patricia Cognome: Dulor Email: send email Telefono: +33 5 40 00 68 02 Fax: +33 5 40 00 22 00	FR (TALENCE)	participant	391˙643.00
3	JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG  Organization address address: SANDERRING 2 city: WUERZBURG postcode: 97070 contact info Titolo: Mr. Nome: Christian Cognome: Gloggengiesser Email: send email Telefono: +49 931 312294 Fax: +49 931 317180	DE (WUERZBURG)	participant	282˙505.00
4	UCB PHARMA SA  Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 contact info Titolo: Mr. Nome: Simon Cognome: Dresse Email: send email Telefono: +32 2 386 3109 Fax: +32 2 385 1293	BE (BRUXELLES)	participant	235˙072.00
5	UCB Celltech  Organization address address: Bath Road 208 city: Slough postcode: SL1 3WE contact info Titolo: Mr. Nome: Simon Cognome: Dresse Email: send email Telefono: +32 2 386 31 09 Fax: +32 2 385 12 93	UK (Slough)	participant	180˙350.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'The Foldappi proposal aims to investigate the potential of aromatic amide Foldamers to disrupt protein-protein interactions. The scientific goals of the project include: 1. development of synthetic methods to build foldamers with different R-group chemistries 2. development of strategies to target foldamers to protein surfaces 3. measuring in vitro properties of foldamer(s) to assess ADME profiles of these molecules In this proposal we propose to explore the use of quinoline-derived aromatic amide foldamers developed at the University of Bordeaux to inhibit protein-protein interactions, namely the interaction between interleukin 4 (IL-4) and its receptor. These foldamers have a very well defined structure that lends itself to the rational design of substituents and the production of focused combinatorial libraries of foldamers capable of interacting with the IL4/IL-4R binding epitope. They are also large enough to block a protein-protein interaction, a feat that is not possible with small molecules. The cytokine IL-4 is a key regulator of the immune system determining the formation of immune cells and immunoglobulin class switching. IL-4 is critically involved in misguided immune reactions during atopic diseases as allergy and asthma. In spite of its importance as a drug target, no small molecule inhibitor of the Il-4/IL-4R has been reported so far, warranting the use of foldamers to do the same. The three partners involved in this cooperation, namely UCB Pharma, Université Bordeaux I and Universität Würzburg each have unique expertises necessary to bring this project to completion. This combination will produce breakthrough knowledge and insights into developing chemistries that can impact in health and medical fields. Moreover, this project will contribute to the personal development of the scientists involved by improving their interdisciplinary knowledge, as well as their communication and experimental skills.'