TRIREME

"Systems-Level, Multi-layer Understanding of Cellular Responses to Ionizing Radiation"

Coordinatore	more  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: -6407805 Fax: -6408728
Nazionalità Coordinatore	Non specificata
Totale costo	3˙841˙740 €
EC contributo	2˙928˙426 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEAL
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2011-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TEL AVIV UNIVERSITY  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: -6407805 Fax: -6408728	IL (TEL AVIV)	coordinator	1˙049˙920.00
2	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Mr. Nome: Joachim Cognome: Gerlach Email: send email Telefono: -84131404 Fax: -84131110	DE (MUENCHEN)	participant	508˙876.00
3	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Edna Cognome: Murphy Email: send email Telefono: + 44 1223 333543 Fax: + 44 1223 332988	UK (CAMBRIDGE)	participant	505˙380.00
4	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Prof. Nome: Ruedi Cognome: Aebersold Email: send email Telefono: +41 44 633 31 70 Fax: +41 44 633 10 51	CH (ZUERICH)	participant	439˙250.00
5	USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE  Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 142 20 contact info Titolo: Prof. Nome: Jiri Cognome: Bartek Email: send email Telefono: +45-35 25 73 57 Fax: -35257676	CZ (PRAHA 4)	participant	425˙000.00

Mappa

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 Obiettivo del progetto (Objective)

'The TRIREME project aims at developing and implementing a multidisciplinary strategy for a systems-level analysis of a cornerstone of cellular homeostasis – the DNA damage response (DDR). The DDR is a complex signaling network that is responsible for maintaining the stability and integrity of the cellular genome in the face of DNA damage. DDR defects underlie acute and chronic forms of human ailments that involve tissue degeneration, premature ageing, sensitivity to environmental agents and cancer predisposition. Importantly, many cancer treatment regimens are based on DNA damaging agents. Therefore, gaining systems-level understanding of the DDR is of paramount importance for human health. TRIREME brings together a multidisciplinary consortium of six world-leading researchers with long-standing expertise in the DDR, cell cycle control, functional genomics, proteomics and computational biology. It will focus on a prototypic DNA damage inducer – ionizing radiation (IR), used extensively in cancer radiotherapy. The critical IR-induced DNA lesion is the double strand break, which vigorously activates the DDR. We will systematically analyze the IR-induced network in all its major layers: gene expression, microRNA expression, the proteome, and key protein post-translational modifications. The analysis is aimed at obtaining a global view of the DDR, and identifying new players in the network. The data obtained by these different approaches will be integrated into coherent models using novel computational algorithms developed for TRIREME. To the best of our knowledge, such an analysis has not been applied before to mammalian systems. The results are expected to have far-reaching ramifications in various biomedical fields, with special importance for clinical oncology.'