PNEUMOPATH
A comprehensive dissection of pneumococcal-host interactions
| Coordinatore | UNIVERSITY OF LEICESTER
Organization address
address: University Road contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 4˙149˙765 € |
| EC contributo | 2˙999˙839 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-B |
| Funding Scheme | CP-FP |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-03-01 - 2012-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITY OF LEICESTER
Organization address
address: University Road contact info |
UK (LEICESTER) | coordinator | 503˙783.00 |
| 2 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 346˙890.00 |
| 3 |
STICHTING KATHOLIEKE UNIVERSITEIT
Organization address
address: GEERT GROOTEPLEIN NOORD 9 contact info |
NL (NIJMEGEN) | participant | 346˙740.00 |
| 4 |
SMITTSKYDDSINSTITUTET
Organization address
address: Nobels vaeg 18 contact info |
SE (SOLNA) | participant | 300˙000.00 |
| 5 |
UNIVERSITA' DEGLI STUDI DI SIENA
Organization address
address: VIA BANCHI DI SOTTO 55 contact info |
IT (SIENA) | participant | 285˙500.00 |
| 6 |
ISLENSK ERFDAGREINING EHF
Organization address
address: Sturlugata 8 contact info |
IS (REYKJAVIK) | participant | 284˙353.00 |
| 7 |
RIJKSUNIVERSITEIT GRONINGEN
Organization address
address: Broerstraat 5 contact info |
NL (GRONINGEN) | participant | 157˙500.00 |
| 8 |
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE INSAT
Organization address
address: AVENUE DE RANGUEIL 135 contact info |
FR (TOULOUSE) | participant | 152˙400.00 |
| 9 |
INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA
Organization address
address: "Avenida da Republica, Estacao Agronomica Nacional" contact info |
PT (OEIRAS) | participant | 150˙000.00 |
| 10 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 150˙000.00 |
| 11 |
INESC ID - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA
Organization address
address: AVENIDA ALVES REDOL 9 contact info |
PT (S JOAO DE DEUS LISBOA) | participant | 149˙977.00 |
| 12 |
TECHNISCHE UNIVERSITAET KAISERSLAUTERN
Organization address
address: GOTTLIEB-DAIMLER-STRASSE Geb. 47 contact info |
DE (KAISERSLAUTERN) | participant | 149˙496.00 |
| 13 |
Intercell AG
Organization address
address: Campus Vienna Biocenter 3 contact info |
AT (Vienna) | participant | 15˙000.00 |
| 14 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 8˙200.00 |
| 15 |
IQ CORPORATION BV
Organization address
address: Rozenburglaan 13A contact info |
NL (GRONINGEN) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'This project is a fundamental, comprehensive study of the host-pathogen interactions during infection with Streptococcus pneumoniae. The expectation is that the basic knowledge gained from this work will give new targets for vaccination, diagnosis and treatment. In PNEUMOPATH, academic and industrial partners will work together in six scientific workpackages. 1) The molecular epidemiology of antibiotic resistant pneumococci 2) The genetic basis of disease susceptibility in the human host and in mice 3) Molecular aspects of virulence and host response in animal models of pneumococcal carriage and disease 4) Molecular aspects of virulence and host response in human cell culture systems 5) Pneumococcal cell biology to determine the role of central metabolic processes and the link to virulence 6) Integrated bioinformatics and data management It is accepted that the outcome of pneumococcal infection is determined by the interplay of both host and pathogen attributes. Pneumococcal isolates vary in the repertoire of genes that they possess. Hence the contribution of an individual factor to the infectious process may vary according to the other host and pathogen factors that are present. To date, study of infection has tended to be a reductionist approach, considering the contribution of each virulence factor or host factor in isolation. Consequently, in searching for targets for antimicrobial therapy or for enhancement of host defence, the contribution of individual factors may be inaccurately estimated. This project will be radically different. Rather than using targeted mutagenesis to create strains of different phenotype for testing, PNEUMOPATH will be a systems biology approach with a checkerboard experimental design Panels of resistant/non-resistant carriage and disease pneumococcal isolates will be used to challenge in vivo and in vitro models, followed by integrated management and analysis of the data with a new semantic web bioinformatic infrastructure.'
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