TIMESIGNAL

Signalling within the mammalian circadian timing system

 Coordinatore UNIVERSITE DE GENEVE 

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 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 2˙360˙136 €
 EC contributo 2˙360˙136 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-04-01   -   2015-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Dr.
Nome: Alex
Cognome: Waehry
Email: send email
Telefono: 41223797560
Fax: 41223791180

CH (GENEVE) hostInstitution 2˙360˙136.00
2    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Ulrich
Cognome: Schibler
Email: send email
Telefono: -3796156
Fax: -3796849

CH (GENEVE) hostInstitution 2˙360˙136.00

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cultured    signalling    identification    liver    physiology    cells    model    clocks    mice    rhythmic    temperature    mechanisms    coding    timing    circadian    components    body   

 Obiettivo del progetto (Objective)

'The main objective of this interdisciplinary research project is to elucidate regulatory mechanisms through which the circadian timing system coordinates temporal physiology. This system has a hierarchical architecture, in that a master clock in the brain s suprachiasmatic nucleus synchronizes subsidiary oscillators in nearly all body cells. The establishment of phase coherence is obviously of utmost importance in the coordination of circadian physiology. While recent studies have identified feeding cycles, hormone rhythms, and body temperature oscillations as timing cues for peripheral clocks, the molecular makeup of the involved signalling mechanisms is largely unknown. Using liver and cultured cells as model systems, we will employ two innovative strategies for the elucidation of relevant signalling pathways. (1) STAR-Prom (Synthetic TAndem Repeat-PROmoter display), a technique developed in our laboratory, will hopefully identify most if not all immediate early transcription factors activated in cultured cells by rhythmic blood-borne and temperature-dependent signals. (2) A transgenic mouse model with conditionally active liver clocks will be explored in the genome-wide identification of coding and non-coding transcripts whose rhythmic accumulation is system-driven. The in vivo significance of the components emerging from these approaches will be assessed via RNA interference. Thus, relevant siRNAs will be injected into the tail vein of mice, and their effect on the phase of circadian liver gene expression will be monitored in freely moving mice by using whole body fluorescence imaging. Physiologically important components will serve as entry points for the identification of upstream and downstream constituents in the corresponding signal transduction cascades.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

ENMUH (2010)

Estimation of Nonlinear Models with Unobserved Heterogeneity

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ADAPTIVES (2010)

Algorithmic Development and Analysis of Pioneer Techniques for Imaging with waVES

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EPIGEPLAS (2008)

Epigenetic determinants of the genome that govern cellular plasticity

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