OptoNeuro
Optogenetic Neural stimulation platform
| Coordinatore | UNIVERSITY OF NEWCASTLE UPON TYNE
Organization address
address: Research and Enterprise Services, Research Beehive, Old Libr 6 contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 2˙941˙024 € |
| EC contributo | 2˙190˙000 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2009-C |
| Funding Scheme | CP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-10-01 - 2014-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITY OF NEWCASTLE UPON TYNE
Organization address
address: Research and Enterprise Services, Research Beehive, Old Libr 6 contact info |
UK (Newcastle upon Tyne) | coordinator | 0.00 |
| 2 |
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
Organization address
address: MAULBEERSTRASSE 66 contact info |
CH (BASEL) | participant | 0.00 |
| 3 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: Exhibition Road, South Kensington Campus contact info |
UK (LONDON) | participant | 0.00 |
| 4 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 5 |
Scientifica Ltd
Organization address
address: Kingfisher Court 1 contact info |
UK (Uckfield) | participant | 0.00 |
| 6 |
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Organization address
address: WESTERN ROAD contact info |
IE (CORK) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
The 2003 breakthrough discovery of a nanoscale optically active cation channel, channelrhodopsin-2, made it possible for the first time, to genetically re-engineer neuron cells to be photosensitive. It became possible to stimulate or inhibit individual action potentials at will, without further chemical modification. The capabilities have been demonstrated in a number of recent high profile journals detailing optical-neural control from cell culture to primate models. The light-gated cation channels were discovered and first applied by European researchers. The photonics and optoelectronics sectors, which can provide new stimulation technologies to this field, are additionally, European strengths. Nevertheless, in recent years, the dominant research output in this area has shifted to well-funded US laboratories.nThis proposal therefore aims to create a consortium to develop an array of ultra bright electronically controlled microLEDs which will provide a truly revolutionary tool for the neuroscience and neurotechnology community. The consortium consists of experts in the field who converge the many disciplines (optics, sophisticated LED fabrication, CMOS flip chip design and bonding, biophysics, molecular biology, neurophysiology) to bear on the complex, and crucial to neuroscience, problem of studying dendritic physiology and neural network dynamics. Advances in the techniques of this field will absolutely be required to further our understanding of brain function. The system we propose to develop will be powerful, sophisticated and at the same time, lead to a commercial spin-out that will provide them at relatively low cost. In the longer term, the tools we develop in this proposal will hasten our long term aims of developing an optogenetic retinal prosthesis.