OptoNeuro

Optogenetic Neural stimulation platform

Coordinatore	UNIVERSITY OF NEWCASTLE UPON TYNE    more  Organization address address: Research and Enterprise Services, Research Beehive, Old Libr 6 city: Newcastle upon Tyne postcode: NE1 7RU contact info Titolo: Dr. Nome: Christine Cognome: Masterson Email: send email Telefono: +44 191 208 5568 Fax: +44 191 208 5920
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙941˙024 €
EC contributo	2˙190˙000 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2009-C
Funding Scheme	CP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-10-01   -   2014-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF NEWCASTLE UPON TYNE  Organization address address: Research and Enterprise Services, Research Beehive, Old Libr 6 city: Newcastle upon Tyne postcode: NE1 7RU contact info Titolo: Dr. Nome: Christine Cognome: Masterson Email: send email Telefono: +44 191 208 5568 Fax: +44 191 208 5920	UK (Newcastle upon Tyne)	coordinator	0.00
2	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH  Organization address address: MAULBEERSTRASSE 66 city: BASEL postcode: 4058 contact info Titolo: Ms. Nome: Dorothy Cognome: Searles Email: send email Telefono: 41616972982 Fax: 41616973976	CH (BASEL)	participant	0.00
3	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: Exhibition Road, South Kensington Campus city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Brooke Cognome: Alasya Email: send email Telefono: +44 207 594 1181 Fax: +44 207 594 1418	UK (LONDON)	participant	0.00
4	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Prof. Nome: Ernst Cognome: Bamberg Email: send email Telefono: 496963000000 Fax: 496963000000	DE (MUENCHEN)	participant	0.00
5	Scientifica Ltd  Organization address address: Kingfisher Court 1 city: Uckfield postcode: TN22 1QQ contact info Titolo: Mr. Nome: David Cognome: Rogerson Email: send email Telefono: +44 1628 519420 Fax: +44 1825 749934	UK (Uckfield)	participant	0.00
6	UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK  Organization address address: WESTERN ROAD city: CORK postcode: - contact info Titolo: Mr. Nome: Conor Cognome: Delaney Email: send email Telefono: +353 21 490 4263 Fax: +353 21 4904058	IE (CORK)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

The 2003 breakthrough discovery of a nanoscale optically active cation channel, channelrhodopsin-2, made it possible for the first time, to genetically re-engineer neuron cells to be photosensitive. It became possible to stimulate or inhibit individual action potentials at will, without further chemical modification. The capabilities have been demonstrated in a number of recent high profile journals detailing optical-neural control from cell culture to primate models. The light-gated cation channels were discovered and first applied by European researchers. The photonics and optoelectronics sectors, which can provide new stimulation technologies to this field, are additionally, European strengths. Nevertheless, in recent years, the dominant research output in this area has shifted to well-funded US laboratories.nThis proposal therefore aims to create a consortium to develop an array of ultra bright electronically controlled microLEDs which will provide a truly revolutionary tool for the neuroscience and neurotechnology community. The consortium consists of experts in the field who converge the many disciplines (optics, sophisticated LED fabrication, CMOS flip chip design and bonding, biophysics, molecular biology, neurophysiology) to bear on the complex, and crucial to neuroscience, problem of studying dendritic physiology and neural network dynamics. Advances in the techniques of this field will absolutely be required to further our understanding of brain function. The system we propose to develop will be powerful, sophisticated and at the same time, lead to a commercial spin-out that will provide them at relatively low cost. In the longer term, the tools we develop in this proposal will hasten our long term aims of developing an optogenetic retinal prosthesis.