DNA MACHINES

Nanomachines based on interlocked DNA architectures

Coordinatore	RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	2˙499˙522 €
EC contributo	2˙499˙522 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100224
Funding Scheme	ERC-AG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-03-01   -   2016-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN  Organization address address: REGINA PACIS WEG 3 city: BONN postcode: 53113 contact info Titolo: Ms. Nome: Daniela Cognome: Hasenpusch Email: send email Telefono: +49 228 737274 Fax: +49 228 736479	DE (BONN)	hostInstitution	2˙499˙522.00
2	RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN  Organization address address: REGINA PACIS WEG 3 city: BONN postcode: 53113 contact info Titolo: Prof. Nome: Michael Cognome: Famulok Email: send email Telefono: +49228 731787 Fax: +49228 735388	DE (BONN)	hostInstitution	2˙499˙522.00

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 Obiettivo del progetto (Objective)

'DNA-nanotechnology has created different topologies, including replicable ones, nanomachines, patterns, logic gates, or algorithmic assemblies. Interlocked double-stranded (ds) DNA-architectures like catenanes or rotaxanes, wherein individual components can be set in motion in a controlled manner have not been accessible. These molecules represent long-sought devices for nanorobotics and nanomechanics because they possess a unique mechanical bonding motif, not available to conventional building blocks. The project will apply an unprecedented, simple, and modular interlocking paradigm for double-stranded (ds) circular DNA geometries that we have developed in preliminary studies. This will now be taken several crucial steps forward by generating unconventional DNA-, protein-, aptamer-, and ribozyme hybrid architectures containing interlocked structures wherein the motion of individual components can be controlled in many different ways. We will design, construct, and evaluate switchable autonomous DNA-nanomachines that function as rotational motors, muscles, or switches for powering and manipulating nanoscale components. The DNA machines envisaged in this project will be applied, for example, in synthetic supramolecular self-assembly systems that emulate complex biological machines like motor proteins, nucleic acid polymerases, or ATPases. In addition, they will be developed for multiple purposes in biosensing, logic-gate- and memory circuit assembly, and catalysis. This efficient method for constructing interlocked dsDNA nanostructures opens the exciting possibility of conjoining the area of lifesciences with that of nanomechanical engineering, paving entirely new avenues for nanotechnology. The project is highly interdisciplinary and will open a new field with enormous innovative potential and implications ranging from chemistry to synthetic biology, and from the life sciences to nano-engineering.'