ICRES
Integration of Chikungunya research
| Coordinatore | THE PIRBRIGHT INSTITUTE
Organization address
address: ASH ROAD PIRBRIGHT contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 5˙055˙096 € |
| EC contributo | 2˙999˙938 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2010-single-stage |
| Funding Scheme | CP-FP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-12-01 - 2014-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE PIRBRIGHT INSTITUTE
Organization address
address: ASH ROAD PIRBRIGHT contact info |
UK (WOKING) | coordinator | 364˙309.84 |
| 2 |
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Organization address
address: RUE LEBLANC 25 contact info |
FR (PARIS 15) | participant | 452˙757.00 |
| 3 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 370˙782.00 |
| 4 |
UNIVERSITE DE LA REUNION
Organization address
address: Avenue Rene Cassin 15 contact info |
FR (SAINT DENIS DE LA REUNION) | participant | 324˙729.00 |
| 5 |
HELSINGIN YLIOPISTO
Organization address
address: YLIOPISTONKATU 4 contact info |
FI (HELSINGIN YLIOPISTO) | participant | 283˙176.00 |
| 6 |
UNIVERSITAETSKLINIKUM BONN
Organization address
address: Sigmund-Freud-Strasse 25 contact info |
DE (BONN) | participant | 262˙440.00 |
| 7 |
THE UNIVERSITY OF EDINBURGH
Organization address
address: OLD COLLEGE, SOUTH BRIDGE contact info |
UK (EDINBURGH) | participant | 255˙493.75 |
| 8 |
Steinbeis Innovation gGmbH
Organization address
address: WILLI BLEICHER STRASSE 19 contact info |
DE (STUTTGART) | participant | 245˙000.00 |
| 9 |
TARTU ULIKOOL
Organization address
address: ULIKOOLI 18 contact info |
EE (TARTU) | participant | 221˙774.00 |
| 10 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | participant | 107˙432.00 |
| 11 |
UNIVERSITY OF MALAYA
Organization address
address: LEMBAH PANTAI contact info |
MY (KUALA LUMPUR) | participant | 64˙545.00 |
| 12 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 37˙500.00 |
| 13 |
BIOMEDICAL SCIENCES INSTITUTES Limited by Guarantee
Organization address
address: BIOPOLIS WAY 20 contact info |
SG (SINGAPORE) | participant | 10˙000.00 |
| 14 |
GRIFFITH UNIVERSITY
Organization address
address: KESSELS ROAD NATHAN 170 contact info |
AU (BRISBANE) | participant | 0.00 |
| 15 |
UNIVERSITY OF GLASGOW
Organization address
address: University Avenue contact info |
UK (GLASGOW) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Since 2005 Chikungunya fever has affected millions of people producing a high fever and a debilitating arthralgia which can persist for months and progress to chronic arthritis. Chikungunya virus has been associated with periodic outbreaks of human disease and is spread by mosquitoes. The current epidemic rose to prominence in 2005/6 following infection of >250,000 people on La Réunion. The virus rapidly spread to other islands in the Indian Ocean, India and SE Asia. Chikungunya cases in returning travellers have been reported. In summer 2007 a traveller from India to Italy initiated a locally transmitted outbreak which included one death from encephalitis. The mosquitoes transmitting this infection are spreading and increasing in Europe and could spread as far north as the British Isles. There are diagnostics tests, these require standardisation. The pathogenic mechanisms leading to myalgia, arthralgia, rare encephalitis and chronic arthritis are unknown precluding rational therapeutic intervention. There are no antivirals. There is no licensed vaccine. This project will integrate the expertise of EU laboratories with a long and strong track record of research on alphaviruses with EU laboratories that started work on CHIKV following the outbreak in La Réunion and laboratories from SE Asia working on this virus. The project will generate new molecular and cellular tools for research and applied studies, including high-throughput screening and vaccines; standardise, quality assure and distribute key diagnostic tests and develop new ones; determine virus genetic changes across time, geographical regions and species; discover interactions between virus and human cells to inform rational design of therapeutics; study immune responses in the chronic disease in humans, including whether virus persists in joints, the cell types involved and the relationship to immune responses; characterise rodent and non-human primate models of acute and chronic infection to further study the pathogenesis and provide models for antiviral and vaccine screens; screen libraries of characterized pharmaceutical and bioactive compounds for antiviral activity and develop a vaccine which at the end of this project is ready to enter clinical trials.'
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