CNKHIV

Characterization of NK cell distributions and functions in human tissues in HIV-1 pathogenesis

Coordinatore	HUMANITAS MIRASOLE SPA    more  Organization address address: "Via Manzoni, 56" city: ROZZANO-MILAN postcode: 20089 contact info Titolo: Mr. Nome: Danilo Cognome: Petroni Email: send email Telefono: 390282000000 Fax: 390282000000
Nazionalità Coordinatore	Italy [IT]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-RG
Funding Scheme	MC-IRG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-02-01   -   2015-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	HUMANITAS MIRASOLE SPA  Organization address address: "Via Manzoni, 56" city: ROZZANO-MILAN postcode: 20089 contact info Titolo: Mr. Nome: Danilo Cognome: Petroni Email: send email Telefono: 390282000000 Fax: 390282000000	IT (ROZZANO-MILAN)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'HIV is an urgent global health problem and a safe and effective vaccine is desperately required. Although many studies have shown that the innate immune system, and in particular, natural killer (NK) cells play a central role in determining the quality of the host immune response to HIV -1, the full host beneficial potential of the anti-HIV-1 NK-mediated activity can not be realized in vivo, as NK cells function becomes compromised in a majority of HIV-1 infected individuals. Several previous experience with HIV-1 infected patients, indicate the significant changes in the redistribution of NK cell subset in the peripheral circulation towards the dysfunctional subpopulation of NK cell. It is likely that the redistribution of NK cell towards this aberrant population may contribute to the observed lack of NK cell function over the course of HIV-1 infection. However, changes in NK cell subset distributions and in effector functions in different anatomical sites and tissues, in healthy donors and in HIV-1 patients, at different stages of HIV-1 infection have been poorly characterized and require further investigation. Given that NK cell are found in female reproductive and in gastrointestinal tracts and that these mucosal layers can play critical roles in the course of HIV-1 infection: as the site of the HIV-1 invasion, as the mother-to-child transmission site, and as the reservoir and important source of virus in HIV-1 infected patients, we propose a multidisciplinary “translational research” project that will exploit: (i) the correlation between tissue-specific distribution of NK cell subpopulation(s) and different stages of HIV-1 infection, (ii) the source of functional and molecular dysfunctions of tissue-specific NK cell subpopulation(s) and their relevance in HIV-1 pathogenesis, (iii) the strategies that virus utilize in local undergoing infections in order to avoid killing by NK cells.'

Introduzione (Teaser)

HIV-1 infection remains a serious health risk with millions of new infections emerging every year. Unravelling the dysfunction of innate immune system mechanisms and natural killer (NK) cells during HIV-1 infection will shed light on HIV-1 pathogenesis.