HIPPOPROJECTION

Role of descending hippocampal outputs in anxiety studied using a novel pharmaco-genetic efferent inhibition tool

Coordinatore	EUROPEAN MOLECULAR BIOLOGY LABORATORY    more  Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 contact info Titolo: Ms. Nome: Genevieve Cognome: Reinke Email: send email Telefono: +49 6221 387 8153 Fax: +49 6221 387 8575
Nazionalità Coordinatore	Germany [DE]
Totale costo	181˙084 €
EC contributo	181˙084 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2013-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	EUROPEAN MOLECULAR BIOLOGY LABORATORY  Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 contact info Titolo: Ms. Nome: Genevieve Cognome: Reinke Email: send email Telefono: +49 6221 387 8153 Fax: +49 6221 387 8575	DE (HEIDELBERG)	coordinator	181˙084.00

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 Obiettivo del progetto (Objective)

'The brain structures and neural circuits regulating anxiety behavior are poorly understood. The hippocampus contribute to anxiety via its role in the behavioral inhibition system and descending outputs via the fornix to the septum and frontal cortex are thought to be critical to this modulating effect. However, it is not clear what the contributions of septal and frontal cortical outputs are to anxiety because, until now, no manipulations were available to selectively inhibit these pathways. Here we propose to develop a pharmacogenetic inhibition technology to selectively manipulate hippocampal efferents and determine the contribution of specific hippocampal outputs to anxiety behavior. The host laboratory has already developed a method for the inhibition of genetically defined cell populations in behaving mice. During the first part of the fellowship, I will develop a modified version of this technology based on axonally transported inhibitory GPCRs that allows for the pharmacological suppression of neurotransmitter release in genetically defined synapses. Later, I will use this technology to examine the behavioral effects of blocking selected hippocampal outputs, with a primary focus on hippocampus-frontal cortex projections. The expectation is that the development and validation of this technology will open up a novel approach to study brain function.'

Introduzione (Teaser)

The role of brain structures such as the hippocampus and associated neural circuits in regulating anxiety and memory is still poorly understood. The EU-funded HIPPOPROJECTION project was initiated to elucidate their role in anxiety and memory regulation using mice models.