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Tendon Therapy Train SIGNED

Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Tendon Therapy Train project word cloud

Explore the words cloud of the Tendon Therapy Train project. It provides you a very rough idea of what is the project "Tendon Therapy Train" about.

vivo skills assembled universities stem transferable phenotype therapy train dimensional cohort competitiveness models credentials involve inter hospitals clinical repair beneficiaries translation fibroblasts subsequently tesa led self cell equivalents cells lineage network assembly dermal interdisciplinary equine countries engineering innovation regeneration medicinal human six doctoral differentiate leadership mimicking ex culture therapies environments multidisciplinary suitable native healthcare lack milieu innovative tissue equip advancements ultimately revolutionise area tendon companies atmp technologies skillset preclinical 15 limiting commercialisation tenogenic training atmps

Project "Tendon Therapy Train" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	https://tendontherapytrain.com/
Total cost	3˙876˙965 €
EC max contribution	3˙876˙965 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-02-01 to 2020-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	1˙062˙698.00
2	TECHNOLOGIKO EKPEDEFTIKO IDRYMA IPIROU TECHNOLOGIKO EKPEDEFTIKO IDRYMA IPIROU Organization address address: GEFYRA ARACHTHON (ARACHTOS BRIDGE) city: ARTA postcode: 47100 website: www.teiep.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ARTA)	participant	727˙160.00
3	THE ROYAL VETERINARY COLLEGE THE ROYAL VETERINARY COLLEGE Organization address address: ROYAL COLLEGE STREET city: LONDON postcode: NW1 OTU website: www.rvc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	546˙575.00
4	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	510˙748.00
5	PROXY BIOMEDICAL LIMITED PROXY BIOMEDICAL LIMITED Organization address address: COILLEACH SPIDDAL city: Galway postcode: H91 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	participant	265˙674.00
6	SOFRADIM PRODUCTION SASU SOFRADIM PRODUCTION SASU Organization address address: AVENUE DE FORMANS 116 city: TREVOUX postcode: 1600 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TREVOUX)	participant	262˙875.00
7	STEMCELL TECHNOLOGIES UK LTD STEMCELL TECHNOLOGIES UK LTD Organization address address: BUILDING 7100 CAMBRIDGDE RESEARCH PARK BEACH DRIVE WATERBEACH city: CAMBRIDGE postcode: CB25 9TL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	262˙875.00
8	UNIVERSIDADE DO MINHO UNIVERSIDADE DO MINHO Organization address address: LARGO DO PACO city: BRAGA postcode: 4704 553 website: www.uminho.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (BRAGA)	participant	238˙356.00
9	STEMCELL TECHNOLOGIES SARL STEMCELL TECHNOLOGIES SARL Organization address address: MINIPAR POLYTEC RUE DES BERGES 40 city: GRENOBLE postcode: 38000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (GRENOBLE)	participant	0.00
10	Aristotle University Aristotle University Organization address address: n.a. city: Thessaloniki postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (Thessaloniki)	partner	0.00
11	Bose Bose Organization address address: Bose House, Quayside, Chatham Maritime city: Chatham postcode: ME4 4QZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Chatham)	partner	0.00
12	Cell Scale Cell Scale Organization address address: n.a. city: Waterloo postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CA (Waterloo)	partner	0.00
13	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	partner	0.00
14	Galway Clinic Galway Clinic Organization address address: n.a. city: Galway postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	partner	0.00
15	NAMSA NAMSA Organization address address: CHEMIN DE L ISLON 115 city: CHASSE SUR RHONE postcode: 38670 website: www.biomatech.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CHASSE SUR RHONE)	partner	0.00
16	PANEPISTIMIO THESSALIAS PANEPISTIMIO THESSALIAS Organization address address: ARGONAFTON FILELLINON city: VOLOS postcode: 38221 website: www.uth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (VOLOS)	partner	0.00

Map

Project objective

Tendon Therapy Train is a research, training and innovation programme for human and equine tendon repair and regeneration that will exploit recent advancements in tissue engineering by self-assembly (TESA) technologies which have led to the clinical translation and commercialisation of advanced therapy medicinal products (ATMPs). Although TESA therapies have the potential to revolutionise healthcare for numerous clinical targets, a lack of researchers with the necessary interdisciplinary skillset to advance the field is limiting clinical translation. Tendon therapy train, a network of 8 beneficiaries and 8 partners (7 universities, 7 companies and 2 hospitals) from six countries across Europe, will train a cohort of 15 researchers to doctoral level in the interdisciplinary area of ATMPs. The innovative credentials of the research and training programme involve engineering suitable ex vivo culture environments that, by mimicking the native tendon tissue milieu (human and equine), will maintain the tenogenic phenotype of tendon derived cells and differentiate non-tendon derived cells (stem cells and dermal fibroblasts) towards the tenogenic lineage, subsequently enabling development of three-dimensional cell-assembled tissue equivalents, the clinical potential of which will be assessed in suitable preclinical models. The comprehensive Tendon Therapy Train programme will equip researchers with transferable inter- and multidisciplinary skills that will further European-based knowledge, innovation, competitiveness and leadership in the field of TESA / ATMP and ultimately enable clinical translation and commercialisation of the developed technologies.

Deliverables

List of deliverables.
Draft Periodic Report	Documents, reports	2019-06-27 11:48:00
IDF and patent filings	Websites, patent fillings, videos etc.	2019-06-27 11:48:00
Ethics	Documents, reports	2019-06-27 11:47:59
Digital media dissemination	Websites, patent fillings, videos etc.	2019-06-27 11:48:00
Mid Term review meeting	Documents, reports	2019-06-27 11:48:00
Progress report	Documents, reports	2019-06-27 11:47:59
Supervisory Board of the Network	Documents, reports	2019-06-27 11:47:59

Take a look to the deliverables list in detail: detailed list of Tendon Therapy Train deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Vassey, Matthew J.; Figueredo, Grazziela P.; Scurr, David; Vasilevich, Aliaksei S.; Vermeulen, Steven; Carlier, AurÃ©lie; Luckett, Jeni; Beijer, Nick R.M.; Williams, Paul; Winkler, Dave; de Boer, Jan; Ghaemmaghami, Amir M.; Alexander, Morgan R. Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation published pages: , ISSN: 2198-3844, DOI: 10.1002/advs.201903392	Advanced Science	2020-04-15
2019	Gifford. V., et. at., British Society for Matrix Biology Spring 2019 Meeting: â€œStroma, Niche, Repairâ€ published pages: , ISSN: 0959-9673, DOI: 10.1111/iep.12332	International Journal of Experimental Pathology 100/4	2020-04-07
2019	Dimitrios Tsiapalis, Shubhasmin Rana, Meletios Doulgkeroglou, Stephen Kearns, Jack Kelly, Yves Bayon, Dimitrios I. Zeugolis The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture published pages: , ISSN: , DOI: 10.1016/bs.mcb.2019.11.003	Methods in Cell Biology	2020-04-07
2019	Diana Gaspar, Rita Peixoto, Andrea De Pieri, Britta Striegl, Dimitrios I. Zeugolis, Michael Raghunath Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs published pages: 126-154, ISSN: 0169-409X, DOI: 10.1016/j.addr.2019.06.002	Advanced Drug Delivery Reviews 146	2020-04-07
2018	Clotilde ThÃ©ry, Kenneth Witwer ISEV2018 abstract book published pages: 1461450, ISSN: 2001-3078, DOI: 10.1080/20013078.2018.1461450	Journal of Extracellular Vesicles 7/sup1	2020-04-07
2019	JoÃ£o Q. Coentro, Andrea De Pieri, Diana Gaspar, Dimitrios Tsiapalis, Dimitrios I. Zeugolis, Yves Bayon Translational Research Symposiumâ€”collaborative efforts as driving forces of healthcare innovation published pages: , ISSN: 0957-4530, DOI: 10.1007/s10856-019-6339-2	Journal of Materials Science: Materials in Medicine 30/12	2020-04-01
2019	Ana I. GonÃ§alves, Dominika Berdecka, MÃ¡rcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes Evaluation of tenogenic differentiation potential of selected subpopulations of human adiposeâ€derived stem cells published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967	Journal of Tissue Engineering and Regenerative Medicine 13/12	2020-03-05
2018	DaniÃ«lle G. Leuning, Nick R. M. Beijer, Nadia A. du FossÃ©, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J. Rabelink, Jan de Boer The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25700-5	Scientific Reports 8/1	2020-03-05
2019	Dimitrios Tsiapalis, Dimitrios I. Zeugolis Hypoxia Preconditioning of Bone Marrow Mesenchymal Stem Cells Before Implantation in Orthopaedics published pages: e1040-e1042, ISSN: 1067-151X, DOI: 10.5435/jaaos-d-19-00044	Journal of the American Academy of Orthopaedic Surgeons 27/23	2020-03-05
2020	Dimitrios Tsiapalis, Andrea De Pieri, Kyriakos Spanoudes, Ignacio Sallent, Stephen Kearns, Jack L Kelly, Michael Raghunath, Dimitrios I Zeugolis The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents published pages: 25018, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab6412	Biofabrication 12/2	2020-03-05
2020	Aysegul Dede Eren, Ravi Sinha, Egemen Deniz Eren, Yuan Huipin, Sultan Gulce-Iz, Henriette Valster, Lorenzo Moroni, Jasper Foolen, Jan de Boer Decellularized Porcine Achilles tendon induces anti-inflammatory macrophage phenotype inÂ Vitro and tendon repair inÂ vivo published pages: 100027, ISSN: 2468-4988, DOI: 10.1016/j.regen.2020.100027	Journal of Immunology and Regenerative Medicine 8	2020-03-05
2019	Anna Sorushanova, Luis M. Delgado, Zhuning Wu, Naledi Shologu, Aniket Kshirsagar, Rufus Raghunath, Anne M. Mullen, Yves Bayon, Abhay Pandit, Michael Raghunath, Dimitrios I. Zeugolis The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development published pages: 1801651, ISSN: 0935-9648, DOI: 10.1002/adma.201801651	Advanced Materials 31/1	2020-02-13
2018	A. Dede-Eren, S. Vermeulen, D. Hebels, J. de Boer Molecular control of tenocyte phenotype through matrix-mediated mechanotransduction published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol 100-B No. Supp_4	2019-06-27
2018	Andrea De Pieri, Sofia Ribeiro, Dimitrios Tsiapalis, David Eglin, Marc Bohner, Peter Dubruel, Philip Procter, Dimitrios I. Zeugolis, Yves Bayon Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs published pages: , ISSN: 0957-4530, DOI: 10.1007/s10856-018-6136-3	Journal of Materials Science: Materials in Medicine 29/8	2019-06-27
2018	A. De Pieri, A. Gorelov, Y. Rochev, D.I. Zeugolis Thermoresponsive nanofibres for engineering extracellular matrix-rich tissue substitutes published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_16	2019-06-27
2018	D. Tsiapalis, D.I. Zeugolis A multifactorial toolbox towards tenogenic phenotype maintenance published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_14	2019-06-27
2018	A. Rampin, I. Skoufos, A. Tzora, N. Prassinos, N. Diakakis, D.I. Zeugolis Engineering optimal culture conditions to maintain tenogenic phenotype published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_15	2019-06-27
2018	I. Sallent, D.I. Zeugolis The synergistic effect of topography and substrate rigidity in the development of a collagen scaffold for tendon tissue engineering published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_16	2019-06-27
2018	S. Garnica-Galvez, I. Skoufos, A. Tzora, N. Prassinos, N. Diakakis, D.I. Zeugolis Assessment of novel macromolecular crowders to produce cell sheets for scaffold-free musculoskeletal tissue regeneration published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_15	2019-06-27
2018	Guillaumin, S., D.I. Zeugolis Tenogenic differentiation of mesenchymal stem cells: a co-culture approach published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_16	2019-06-27
2018	A. Dei, W. Chang, A. Sampaio, D. Zeugolis Development of serum-free culture conditions for differentiation of bone marrow-derived mesenchymal stromal cells from tenocyte-like cells published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_15	2019-06-27
2018	E. Pugliese, S. Korntner, D.I. Zeugolis Multilayer collagen-based scaffold as delivery vehicles of bioactive molecules for the bone-to-tendon interface regeneration published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_14	2019-06-27
2018	Sarita Kumari, Steven Vermeulen, Ben van der Veer, AurÃ©lie Carlier, Jan de Boer, Deepa Subramanyam Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells published pages: 255-266, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2017.0468	Tissue Engineering Part B: Reviews 24/4	2019-06-27
2018	D. Berdecka, P.S. Babo, R.L. Reis, M.E. Gomes Effect of transforming growth factor beta 3 and growth/differentiation factor 5 on the expression of tendon/ligament markers in human dental pulp stem cells and periodontal ligament cells published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No SUPP_15	2019-06-27
2018	A. Djalali-Cuevas, I. Skoufos, A. Tzora, N. Prassinos, N. Diakakis, D.I. Zeugolid RNA sequencing and meta-profiling for a better understanding of the musculoskeletal system biology published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No SUPP_15	2019-06-27
2018	S. Ribeiro, V. Novacek, E.M. Fernandes, M.E. Gomes, R.L. Reis, Y. Bayon, D.I. Zeugolis Design and characterization of synthetic biodegradable films for musculoskeletal tissue engineering published pages: , ISSN: , DOI:	Orthopaedic Proceedings Vol. 100-B, No. SUPP_15	2019-06-27
2018	JoÃ£o Q. Coentro, Eugenia Pugliese, Geoffrey Hanley, Michael Raghunath, Dimitrios I. Zeugolis Current and upcoming therapies to modulate skin scarring and fibrosis published pages: digital, ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.08.009	Advanced Drug Delivery Reviews Theme issue format	2019-06-27
2019	Steven Vermeulen, Aliaksei Vasilevich, Dimitrios Tsiapalis, Nadia Roumans, Pascal Vroemen, Nick R.M. Beijer, Aysegul Dede Eren, Dimitrios Zeugolis, Jan de Boer Identification of topographical architectures supporting the phenotype of rat tenocytes published pages: 277-290, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.10.041	Acta Biomaterialia 83	2019-06-27

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