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SPCCT SIGNED

In Vivo Spectral Photon Counting CT Molecular Imaging in Cardio- and Neuro-Vascular Diseases

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SPCCT project word cloud

Explore the words cloud of the SPCCT project. It provides you a very rough idea of what is the project "SPCCT" about.

tomography healthcare gold combining detect designed outcomes atoms harmonization ct angiography rate earlier gadolinium tool validate bismuth edge disability stroke spcct computed achievable sustainability plaque imaging combined accurate accessible probes quality disorders economic 200 totally discrimination presenting monitor acute heart modality variety decisions detection quantify treatment quantitative diagnosis contrast spectral mi atherosclerosis diagnostics counting rupture costly efficiency accurately smes inflammation ray vascular ivus agent technique clinical event resolution analytical preventive detected agents disease personalized evaluation cv complete coronary newly micro count prevention patient materials invasive vivo spatial photon validation prevented cardiovascular acquisition neurovascular chain energy

Project "SPCCT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE LYON 1 CLAUDE BERNARD Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 website: www.univ-Iyon1.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.spcct.eu
Total cost	6˙441˙663 €
EC max contribution	6˙441˙663 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE LYON 1 CLAUDE BERNARD UNIVERSITE LYON 1 CLAUDE BERNARD Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 website: www.univ-Iyon1.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEURBANNE CEDEX)	coordinator	2˙142˙356.00
2	PHILIPS MEDICAL SYSTEMS TECHNOLOGIES LTD PHILIPS MEDICAL SYSTEMS TECHNOLOGIES LTD Organization address address: SCIENTIFIC INDUSTRIES CENTER HAIFA 31004 ISENA RAODNICH city: Haifa postcode: 325 Haifa website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (Haifa)	participant	1˙505˙000.00
3	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	535˙500.00
4	Philips GmbH Philips GmbH Organization address address: Luebeckertordamm 5 city: Hamburg postcode: 20099 website: www.philips.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Hamburg)	participant	442˙375.00
5	ERASMUS UNIVERSITEIT ROTTERDAM ERASMUS UNIVERSITEIT ROTTERDAM Organization address address: BURGEMEESTER OUDLAAN 50 city: ROTTERDAM postcode: 3062 PA website: www.eur.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	405˙478.00
6	VOXCAN VOXCAN Organization address address: 1, AVENUE BOURGELAT city: MARCY L'ETOILE postcode: 69280 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MARCY L'ETOILE)	participant	392˙201.00
7	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	331˙968.00
8	MATHYM MATHYM Organization address address: 22 RUE DES AULNES city: CHAMPAGNE-AU-MONT-D'OR postcode: 69410 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CHAMPAGNE-AU-MONT-D'OR)	participant	269˙062.00
9	LYON INGENIERIE PROJETS LYON INGENIERIE PROJETS Organization address address: BD DU 11 NOVEMBRE 1918 43 L ATRIUM city: VILLEURBANNE postcode: 69616 website: www.lyoningenierie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEURBANNE)	participant	229˙750.00
10	CLINIQUES UNIVERSITAIRES SAINT-LUC CLINIQUES UNIVERSITAIRES SAINT-LUC Organization address address: AVENUE HIPPOCRATE 10 city: BRUXELLES postcode: 1200 website: http://www.saintluc.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	96˙720.00
11	BRACCO IMAGING SPA BRACCO IMAGING SPA Organization address address: VIA EGIDIO FOLLI 50 city: MILAN postcode: 20134 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILAN)	participant	91˙250.00

Map

Project objective

The objective of the SPCCT project is to develop and validate a widely accessible, new quantitative and analytical in vivo imaging technology combining Spectral Photon Counting CT and contrast agents, to accurately and early detect, characterize and monitor neurovascular and cardiovascular disease. Spectral Photon Counting Computed Tomography (SPCCT) is a new imaging modality, currently in development, with a totally new type of detection chain designed to provide high count-rate capabilities while offering energy discrimination with high spatial resolution of 200µm. Based on this discrimination, SPCCT can detect and quantify accurately a large variety of atoms (including Gadolinium, Gold, Bismuth…) by using the K-edge technique. SPCCT, by a more accurate, less invasive (in comparison with IVUS and coronary angiography) and reliable evaluation of vascular inflammation will allow earlier disease diagnosis such as plaque inflammation before rupture, leading to improved clinical decisions and outcomes. This will be achievable with a high spatial resolution combined to the newly developed vascular inflammation specific contrast agent detected with high quality K-edge technique that can only be provided by a multi-spectral X-ray system. The project will therefore provide a complete tool (acquisition system and specific probes) dedicated to CV imaging. It will finally contribute to: Improved early diagnosis of atherosclerosis, prevention of acute event (MI, stroke) and personalized preventive treatment; Improved management of patient presenting with an acute CV event and clinical validation of treatment efficiency; Sustainability and harmonization of healthcare systems, as costly disorders of heart failure and stroke-related disability would be better prevented and efficiently treated; Economic growth in the EU diagnostics sector, through the development of new targeted contrast materials for SPCCT by SMEs.

Deliverables

List of deliverables.
Selection of the most promising nanoparticles to be used as contrast agents for SPCCT	Documents, reports	2020-04-07 20:32:01
Press release 2	Other	2020-04-07 20:32:01
Ethics report on pre-clinical studies	Documents, reports	2020-04-07 20:32:01
management report 1	Documents, reports	2020-04-07 20:32:01
Functionalization of the nanoparticles for targeting relevant biomarkers	Documents, reports	2020-04-07 20:32:01
Preliminary exploitation strategy	Documents, reports	2020-04-07 20:32:01
Mid-term open Workshop	Other	2020-04-07 20:32:01
Report of results on small animals	Documents, reports	2020-04-07 20:32:01
Identification of the sensitivity threshold for the preparation of SPCCT contrast agents	Documents, reports	2020-04-07 20:32:01
Project website	Websites, patent fillings, videos etc.	2020-04-07 20:32:01
Communication plan and dissemination strategy	Documents, reports	2020-04-07 20:32:01
Comprehensive overview of current care of imaging atherosclerotic patients in four major European countries	Documents, reports	2020-04-07 20:32:00
Project handbook and internal platform	Documents, reports	2020-04-07 20:32:01
Press release 1	Other	2020-04-07 20:32:01

Take a look to the deliverables list in detail: detailed list of SPCCT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Grischa Bratke, Tilman Hickethier, Daniel Bar-Ness, Alexander Christian Bunck, David Maintz, Gregor Pahn, Philippe Coulon, Salim Si-Mohamed, Philippe Douek, Monica Sigovan Spectral Photon-Counting Computed Tomography for Coronary Stent Imaging published pages: 61-67, ISSN: 0020-9996, DOI: 10.1097/rli.0000000000000610	Investigative Radiology 55/2	2020-04-07
2019	Isabelle Riederer, Salim Si-Mohamed, Sebastian Ehn, Daniel Bar-Ness, Peter B. NoÃ«l, Alexander A. Fingerle, Franz Pfeiffer, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer Differentiation between blood and iodine in a bovine brainâ€”Initial experience with Spectral Photon-Counting Computed Tomography (SPCCT) published pages: e0212679, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0212679	PLOS ONE 14/2	2020-04-07
2018	Cyril Mory, Bruno Sixou, Salim Si-Mohamed, LoÃ¯c Boussel, Simon Rit Comparison of five one-step reconstruction algorithms for spectral CT published pages: 235001, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aaeaf2	Physics in Medicine & Biology 63/23	2020-04-07
2018	Felix K. Kopp, Heiner Daerr, Salim Si-Mohamed, Andreas P. Sauter, Sebastian Ehn, Alexander A. Fingerle, Bernhard Brendel, Franz Pfeiffer, Ewald Roessl, Ernst J. Rummeny, Daniela Pfeiffer, Roland Proksa, Philippe Douek, Peter B. NoÃ«l Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging published pages: 2018; 8: 17386., ISSN: 2045-2322, DOI: 10.1038/s41598-018-35888-1	Scientific Reports 8/1	2020-04-07
2019	Salim Si-Mohamed, ValÃ©rie Tatard-Leitman, Alexis Laugerette, Monica Sigovan, Daniela Pfeiffer, Ernst J. Rummeny, Philippe Coulon, Yoad Yagil, Philippe Douek, Loic Boussel, Peter B. NoÃ«l Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multi-phase liver imaging with a dual contrast agent protocol published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-44821-z	Scientific Reports 9/1	2020-04-07
2018	Johoon Kim, Daniel Bar-Ness, Salim Si-Mohamed, Philippe Coulon, Ira Blevis, Philippe Douek, David P. Cormode Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30570-y	Scientific Reports 8/1	2020-04-07
2019	Yuxi C. Dong, Maryam Hajfathalian, Portia S. N. Maidment, Jessica C. Hsu, Pratap C. Naha, Salim Si-Mohamed, Marine Breuilly, Johoon Kim, Peter Chhour, Philippe Douek, Harold I. Litt, David P. Cormode Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-50332-8	Scientific Reports 9/1	2020-04-07
2019	S.A. Si-Mohamed, P.C. Douek, L. Boussel TomodensitomÃ©trie spectraleÂ : de la double Ã©nergie Ã la multiÃ©nergie published pages: 32-45, ISSN: 2543-3431, DOI: 10.1016/j.jidi.2018.11.004	Journal d\'imagerie diagnostique et interventionnelle 2/1	2020-04-07
2017	Daniela Muenzel, Heiner Daerr, Roland Proksa, Alexander A. Fingerle, Felix K. Kopp, Philippe Douek, Julia Herzen, Franz Pfeiffer, Ernst J. Rummeny, Peter B. NoÃ«l Simultaneous dual-contrast multi-phase liver imaging using spectral photon-counting computed tomography: a proof-of-concept study published pages: 2017;1(1):25., ISSN: 2509-9280, DOI: 10.1186/s41747-017-0030-5	European Radiology Experimental 1/1	2020-04-07
2019	Isabelle Riederer, Daniel Bar-Ness, Melanie A. Kimm, Salim Si-Mohamed, Peter B. NoÃ«l, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer Liquid Embolic Agents in Spectral X-Ray Photon-Counting Computed Tomography using Tantalum K-Edge Imaging published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41737-6	Scientific Reports 9/1	2020-04-07
2018	Salim Si-Mohamed, Arnaud Thivolet, Pierre-Emmanuel Bonnot, Daniel Bar-Ness, Vahan KÃ©pÃ©nÃ©kian, David P. Cormode, Philippe Douek, Pascal Rousset Improved Peritoneal Cavity and Abdominal Organ Imaging Using a Biphasic Contrast Agent Protocol and Spectral Photon Counting Computed Tomography K-Edge Imaging published pages: 629-639, ISSN: 0020-9996, DOI: 10.1097/rli.0000000000000483	Investigative Radiology 53/10	2020-04-07
2019	Niki Halttunen, Frederic Lerouge, Frederic Chaput, Marc Vandamme, Szilvia Karpati, Salim Si-Mohamed, Monica Sigovan, Loic Boussel, Emmanuel Chereul, Philippe Douek, Stephane Parola Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification published pages: Sci Rep 9, 12090, ISSN: 2045-2322, DOI: 10.1038/s41598-019-48641-z	Scientific Reports 9/1	2020-04-07
2018	J F P J Abascal, N Ducros, F Peyrin Nonlinear material decomposition using a regularized iterative scheme based on the Bregman distance published pages: 124003, ISSN: 0266-5611, DOI: 10.1088/1361-6420/aae1e7	Inverse Problems 34/12	2020-04-07
2017	Anne-Claire Peultier, Ken Redekop, Emmanuel Coche, Johan L Severens What are the images used to diagnose and assess suspected strokes?: A systematic literature review of care in four European countries published pages: 177-189, ISSN: 1473-7167, DOI: 10.1080/14737167.2018.1429270	Expert Review of Pharmacoeconomics & Outcomes Research 18/2	2020-04-07
2018	Julia Dangelmaier, Daniel Bar-Ness, Heiner Daerr, Daniela Muenzel, Salim Si-Mohamed, Sebastian Ehn, Alexander A. Fingerle, Melanie A. Kimm, Felix K. Kopp, Loic Boussel, Ewald Roessl, Franz Pfeiffer, Ernst J. Rummeny, Roland Proksa, Philippe Douek, Peter B. NoÃ«l Experimental feasibility of spectral photon-counting computed tomography with two contrast agents for the detection of endoleaks following endovascular aortic repair published pages: 3318-3325, ISSN: 0938-7994, DOI: 10.1007/s00330-017-5252-7	European Radiology 28/8	2020-04-07
2018	Martina Tripepi, Federico Capuana, Eliana Gianolio, FlÃ¡vio Vinicius CrizÃ³stomo Kock, Amerigo Pagoto, Rachele Stefania, Giuseppe Digilio, Silvio Aime Synthesis of High Relaxivity Gadolinium AAZTA Tetramers as Building Blocks for Bioconjugation published pages: 1428-1437, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00120	Bioconjugate Chemistry 29/4	2020-04-07

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